2025 Leagues Cup: Inter Miami CF vs. Orlando City SC Odds, Prediction & Picks

• Inter Miami aim to book their trip to the Leagues Cup final for the second time in three years 

• Orlando City SC saw its eight-game unbeaten run come to a halt on Saturday 

An in-state derby will occur on Wednesday evening as Inter Miami hosts Orlando City SC. This semifinal clash will take place at Chase Stadium in Fort Lauderdale, Florida. 

Here, we will break down the betting odds and share our favourite picks for Inter Miami CF vs. Orlando City SC.

Inter Miami CF vs. Orlando City SC Betting Odds for Wednesday, August 27

To win in regulation time, the hosts are pegged as the firm favourite, as the Herons are priced at -125. The moneyline 3-way market sees Orlando listed at +270. If both sides are level after the 90-minute frame, the draw is logged in at +280.

Inter Miami CF vs. Orlando City SC Odds

The following odds are taken from bet365 sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $200 in Bonus Bets Win or Lose. Read our bet365 sportsbook review and get more info.

Inter Miami CF vs. Orlando City SC Betting Prediction

Inter Miami CF Preview

The quarterfinal stage saw Javier Mascherano’s men get the better of one of the giants in Liga MX, defeating Tigres UANL 2-1. The 2023 Leagues Cup winners had to grind out another match without their world-class player, Lionel Messi. Across all competitions since their FIFA Club World Cup elimination, the Herons have only suffered two setbacks in 13 games. 

Luis Suárez played the hero in last week's Leagues Cup contest, bagging two goals from the penalty area. When the 38-year-old striker is inserted into the starting lineup, Suárez has delivered devastating displays, amassing four goals and two assists across MLS and Leagues Cup play in 352 minutes of work.

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Orlando City SC Preview

In MLS on Saturday, Óscar Pareja’s troops will look to rebound after getting throttled against Nashville SC. Getting dispatched 5-1, the Lions' impressive run of cataloging results ended embarrassingly, sustaining their heaviest defeat in 2025. After a successful opening round in the Leagues Cup, Orlando took down the reigning Liga MX champions, Toluca, in the quarterfinals to reach the final four in the tournament. 

The club’s top striker should be ready for Wednesday’s clash, as Martin Ojeda had the evening off against Nashville SC over the weekend. A well-rested lethal striker could cause havoc against Inter Miami, as the attacking forward has hit the back of the net on 17 occasions between MLS and Leagues Cup. His outing against Toluca was the first time in seven instances Ojeda didn’t obtain a goal or an assist across all competitions.

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Inter Miami CF vs. Orlando City SC - My Pick

• Inter Miami CF vs. Orlando City SC pick: Inter Miami CF moneyline 3-way (-125) at bet365

The Florida Derby transpired a few weeks ago, and it saw Orlando cruise to a 4-1 win, winning the MLS regular season series battle. Despite outscoring Miami 7-1 on aggregate this year, we sense this tilt will see Inter Miami finally find a way to overcome their counterpart. The Herons started a heavily rotated side on Saturday with key players stapled to the bench.

We feel this benefits the hosts being well rested entering Wednesday's match. In eight all-time matches occurring at Chase Stadium, Inter Miami has been victorious on five occasions in this matchup. The tourney favourites will want to seek revenge and fancy the bragging rights back in their corner, abolishing Orlando's chance at silverware. It’s risky backing a Messi-less side, but we feel the Herons will do everything possible to reach another final.

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How to Watch Inter Miami CF vs. Orlando City SC

• When: August 27, 8.30 p.m. ET

• Where: Chase Stadium

• TV: Apple TV - MLS Season Pass, Apple TV+