Club Leon vs. Cruz Azul Prediction: La Maquina Seek to Stay Unbeaten vs. Leon in Quarter-Final Opener

• Club Leon finished the 2025 Clausura campaign acquiring 30 points in 17 games finishing sixth overall 

• Cruz Azul seek another run to the final, finishing as runners up in during the 2024 Clausura season 

The quarter-finals in the playoff phase kickoff with Club Leon hosting Cruz Azul at Estadio Leon. These two opponents most recently clashed back on April 15, which saw La Máquina secure a 2-1 victory on their home turf. 

Here, we will break down the betting odds and share our favourite picks for Club Leon vs. Cruz Azul.

Club Leon vs. Cruz Azul betting Odds for Wednesday, May 7

Rolling into Wednesday’s tilt, the books sense both clubs will feature on the scoreboard with the indicated odds. Both teams finding the back of the net is priced at -163, while both failing to do so is listed at +120.

Club Leon vs. Cruz Azul Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose

Club Leon vs. Cruz Azul Betting Prediction

Club Leon Preview

Eduardo Berizzo’s men enter this playoff contest in a bit of a tailspin, only obtaining a maximum result once in their previous seven games. On Matchday 17, Los Panzas Verdes were soundly beaten at home when they faced off against C.F. Monterrey, losing 2-0. 

Finishing the 2025 Clausura regular season as the club's leading goal-getter, Jhonder Cadiz will need to halt his scoring drought to get past Cruz Azul. Finding the back of the net on seven occasions in 17 outings, the Venezuelan striker has gone four straight without a tally. 

James Rodriguez found success competing in his first regular season in Liga MX. The Colombian star amassed six assists in 16 league appearances. Wearing the captain's armband in 14 instances, the 33-year-old veteran presence will be a welcomed addition to this club seeking playoff achievements.

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Cruz Azul Preview

Vicente Sanchez’s troops arrive into the postseason on high as Los Celestes have not lost in their 16 matches across all competitions. Cruz Azul closed out the regular season phase in the 2025 Clausura with a 2-2 draw on the road versus Toluca. 

Ignacio Rivero led the way this campaign for his side with five goals in just over 1000 minutes of play. The 33-year-old has not hit the back of the net since March 29. Rivero joined Cruz Azul in June 2021, appearing in 167 shifts on the pitch while registering 20 goals across all competitions played.

Missing three of the last six games of the campaign, Georgios Giakoumakis will look to find his footing in the team’s chase for a title. The Greek international was the club's marquee signing last summer coming over from Atlanta United in MLS. During 672 minutes of league play in 2025, the striker cataloged two goals and three assists. His sophomore stint was well off his Apertura stats where he notched six goals and four assists.

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Club Leon vs. Cruz Azul - My Pick

• Club Leon vs. Cruz Azul pick: Both teams to score yes (-163) at bet365

Checking into this first-leg quarter-final skirmish, we feel both sides can get onto the scorers' sheet. In the 17 regular phase affairs each side played in, Club Leon finished with the best record with both teams scoring in a match with it transpiring in 13 instances while for Cruz Azul it materialized in 11 junctures. Head-to-head in this encounter the previous three clashes resulted in both keepers being breached, on Wednesday this trend should continue.

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How to Watch Club Leon vs. Cruz Azul

• When: May 7, TBD 

• Where: Estadio Leon

• TV: FOX Deportes, Univision, UniMas, Telemundo, Universo, TUDN, ESPN Deportes, ESPN+ and ViX+