Cruz Azul vs. Club America Prediction: Clasico Joven Semi-Final Bragging Rights on the Line

• Cruz Azul is one of the hottest clubs in Mexico, riding an 18-game unbeaten run across all competitions 

• Three-peat league champions, Club America, have lost once in their previous five contests 

Thursday evening, one of the fiercest rivalries in club soccer across the globe will take place at the Estadio Olimpico Universitario, the temporary home for Cruz Azul as they renew hostilities against Club America. These Mexico City-based sides have clashed against each other over 200 times in this notable confrontation. 

Here, we will break down the betting odds and share our favourite picks for Cruz Azul vs. Club America.

Cruz Azul vs. Club America Betting Odds for Thursday, May 15

In the draw no bet market, the hosts in this tilt are the noted favourites. Cruz Azul are priced at -150 while Club America are listed at +110.

Cruz Azul vs. Club America Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose

Cruz Azul vs. Club America Betting Prediction

Cruz Azul Preview

Vicente Sanchez’s men are one of the best stories in the soccer world in 2025, as the team has yet to suffer a setback since February 15. La Maquina eliminated Club Léon on Sunday, winning 2-1 in leg two, finishing the two-game aggregate on top 5-3 during the quarter-final stage. 

The cagey veteran up front, Angel Sepulveda, acquired an assist setting up the opening score against Club Leon. In his 80 minutes of work, the striker garnered three shots towards the target but failed to hit the net. The club is hoping Sepulveda can breach the keeper in this two-game battle, as he hadn’t scored a goal in Liga MX play since March 15. 

Scoring in both quarter-final outings against Club Leon, Jose Rivero will be counted on again to produce against the giants of Liga MX. The 33-year-old midfielder put together a sufficient campaign, cataloging seven goals and one assist in over 1000 minutes played. 

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Club America Preview

Since bowing out of the CONCACAF Champions Cup, Andre Jardine’s crew have been brick walls keeping the ball out of their net. La Aguilas’ past five affairs have only seen them concede one goal, including shutting out Pachuca completely in their quarter-final matchup. 

The star of the show on Saturday was Alex Zendejas, who was awarded the Player of the Match on Saturday. His brilliant display saw him breach the keeper on two occasions off four shots he took against Pachuca. Between the regular season and playoff phase, the American international has 13 goal contributions to his account, averaging 77 minutes played per game. 

Between the sticks, Luis Malagon is rated as one of the top keepers in the Mexican top-flight division, with his stats backing up his body of work in 2025. Starting in 15 domestic league matches, the netminder has obtained eight clean sheets and currently possesses a 0.5 goals against average. The 28-year-old will have to be on his toes facing a club that can do damage on attack.

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Cruz Azul vs. Club America - My Pick

• Cruz Azul vs. Club America pick: Club America draw no bet (+110) at bet365

The Clasico Joven is an intense rivalry and has only gotten more heated in recent times, as this is the third consecutive postseason that these two adversaries will tussle against each other. La Aguilas will have revenge on their mind, looking to return the favour as they were bounced out of CONCACAF Champions Cup play against their inner city hated rivals a few weeks ago. Dating back to 2010, a span of 36 matches, Club America retains a small advantage in the head-to-head department, winning on 17 occasions versus Cruz Azul’s 13 wins. Though this is a fairly even encounter, we feel the visitors can escape Thursday's game unscathed, showcasing the plethora of talent and relentless depth they have employed on this roster.

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How to Watch Cruz Azul vs. Club America

• When: May 15, 10 p.m. ET

• Where: Estadio Olímpico Universitario

• TV: FOX Deportes, Univision, UniMas, Telemundo, Universo, TUDN, ESPN Deportes, ESPN+ and Vix+