Santos Laguna vs. Cruz Azul Prediction: La Maquina Looks To Maintain Top Spot

• Santos Laguna halted their four-game losing skid with a draw in matchday eight 

• Cruz Azul are looking unstoppable at the moment, sitting atop the table 

There’s no rest for the wicked, as this matchup will occur on Tuesday evening after a tight turnaround in the schedule. Cruz Azul will travel to Estadio Corona to clash against Santos Laguna. 

Here, we will break down the betting odds and share our favourite picks for Santos Laguna vs. Cruz Azul.

Santos Laguna vs. Cruz Azul Betting Odds for Tuesday, March 3

The Asian spread has pegged the visitors to win more than by a one-goal margin at -110. The exact odds are also given for the home side to win or draw. For refund protection, a one-goal win or loss results in a push.

Santos Laguna vs. Cruz Azul Odds

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Santos Laguna vs. Cruz Azul Betting Prediction

Santos Laguna Preview

After a poor 2026, the club decided to go in a new direction and appoint Omar Tapia as the caretaker manager. The Guerreros are currently occupying the last spot in the Clausura standings, obtaining a lowly two points after eight fixtures. If there is a positive to take from Club Santos, they refused to let one slip into the loss column as they shared the spoils in a 2-2 draw against 17th-place Querétaro on Friday. 

Regardless of the signs of glimmer, Santos Laguna did themselves zero favours late in their match over the weekend, letting their undisciplined composure get the best of them. Their leading striker, Lucas Di Yorio, and one of their top defensive midfielders, Carlos Gruezo, were shown red cards. Di Yorio has had a solid campaign, cataloging four goals and an assist in just over 500 minutes of work.

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Cruz Azul Preview

Almost halfway through the 2026 Clausura term, Nicolás Larcamón and his colleagues have entered the chat as title contenders. La Máquina are one of the teams firing on all cylinders, as they have not suffered a setback across all competitions since losing their season opener back in January. Fresh off another win, Cruz Azul got the better of C.F. Monterrey over the weekend, obtaining a two-goal clean sheet win in enemy territory. 

For 90 minutes, Carlos Rotondi terrorized the opposition on the left flank, as the dependable winger earned himself the Player of the Match honours. The 29-year-old broke the deadlock early in the 17th minute against C.F. Monterrey, obtaining his second tally of the year. Putting the match to bed, Agustín Palavecino found the back of the net for the third time for his new employers in his eighth league outing. The attacking midfielder is on pace to surpass his Liga MX single-season high in goals, set twice while playing for Necaxa, with four.

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Santos Laguna vs. Cruz Azul - My Pick

• Santos Laguna vs. Cruz Azul pick: Cruz Azul -1 (-110) at bet365

Leading up to this game, the visitors possess all the momentum not only to win but to crush their adversary on Tuesday. Two of Cruz Azul’s six victories were two-goal cushions. Still, with Santos Laguna missing key players due to suspensions, we like the prospect of Cruz Azul overwhelming the opposition, which is surrendering an average of just over 2 goals per match at Estadio Corona. It’s more a case of first versus worst; we feel Cruz Azul are just too much of a team to deal with and will avoid any new manager bounce Santos Laguna is aiming to receive. Cruz Azul has seemed to have gotten Santos Laguna’s number in recent memory, targeting a fourth consecutive victory in this midweek tilt.

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How to Watch Santos Laguna vs. Cruz Azul

• When: March 3, 8 pm ET 

• Where: Estadio Corona

• TV: Univision Networks (Univision, UniMás, TUDN), DirecTV Stream, CBS Sports, ViX