2025 Leagues Cup: Inter Miami CF vs. Tigres UANL Odds, Prediction & Picks

• Inter Miami possess the third-best record overall in MLS based on points per game, averaging 1.88

• Round five in the Apertura saw Tigres UANL succumb to their first league defeat

On Wednesday evening, Chase Stadium will be where Inter Miami CF welcomes Tigres UANL for a quarterfinals showdown. These two met on one occasion during last year’s edition of the League Cup, which saw La U de Nuevo León secure a 2-1 win. 

Here, we will break down the betting odds and share our favorite picks for Inter Miami CF vs. Tigres UANL. 

Inter Miami CF vs. Tigres UANL Betting Odds for Wednesday, August 20

The books have pegged Inter Miami or Tigres to win inside the 90-minute frame as the favorite in the double chance market at -350. Inter Miami to win or draw is priced at -250, while the visitors for the exact outcome is listed at -163. 

Inter Miami CF vs. Tigres UANL Odds

The following odds are taken from bet365 sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose. Read our bet365 sportsbook review and get more info.

Inter Miami CF vs. Tigres UANL Betting Prediction

Inter Miami CF Preview

After a drubbing setback, Javier Mascherano’s troops rebounded nicely with a 3-1 triumph over the defending MLS champions, the LA Galaxy, on Saturday evening. The first phase of the Leagues Cup saw the Herons go undefeated, obtaining eight out of a possible nine points. The 2023 tournament winners saw the return of their marquee player, Lionel Messi, back in action after missing time with a muscle injury back on August 2nd. 

The eight-time Ballon d'Or winner Messi made a second-half cameo this weekend, displaying another class performance. He registered a goal and an assist. Messi will most likely see action on Wednesday, but it is yet to be determined if he is fully fit to start or come off the bench again.

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Tigres UANL Preview 

Guido Pizarro’s men encountered Liga MX giants Club America over the weekend, which saw Tigres suffer their first setback in the campaign. During the League Cup opening round, the Tigers of Mexico finished fourth overall thanks to victories over the Houston Dynamo and San Diego FC. 

Going forward, there is no production shortage from this side as they currently boast the highest goals per match average across Liga MX, scoring 3.3 goals per game. With seven members etching their name on the scores’ sheet, Ozziel Herrera leads the pact, cataloging three tallies through four Apertura outings. Tigres have employed the 24-year-old since July 2023. Across all competitions played, the Mexican international has amassed 15 goals and eight assists.

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Inter Miami CF vs. Tigres UANL - My Pick

• Inter Miami CF vs. Tigres UANL pick: Tigres UANL double chance (-163) at bet365

Despite the Herons enjoying this encounter on familiar ground, we feel Tigres have a reasonable chance to walk into Chase Stadium and upend Messi and co. Inter Miami have piled up matches played in 2025, especially since mid-June. In 36 days, Wednesday’s clash will be their 16th match played. With Messi not 100 percent fully fit, aging star players like Luis Suárez and the pair of Spaniard compatriots Alba and Busquets fatigued from a heavy workload, it plays into the hands of the visitors. Tigres are the much fresher side between the two; they should have a bounce-back performance after getting dismantled by Las Águilas. The away side should escape this fixture and proceed to the semifinals. 

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How to Watch Inter Miami CF vs. Tigres UANL

• When: August 20, 8 p.m. ET

• Where: Chase Stadium 

• TV: Apple TV - MLS Season Pass, Apple TV+, FS1