2025 Leagues Cup: Toluca vs. Orlando City SC Odds, Prediction & Picks

• The 2025 Clausura Champions, Toluca, currently occupy fourth place in Liga MX

• Orlando City SC are sitting comfortably in MLS’ Eastern Conference, obtaining 47 points through 27 matches 

Wednesday evening at Dignity Health Sports Park in Carson, California, will be the neutral site venue for this quarterfinal encounter between Toluca and Orlando City SC. This will be the first-ever meeting between these two sides. 

Here, we will break down the betting odds and share our favourite picks for Toluca vs. Orlando City SC. 

Toluca vs. Orlando City SC Betting Odds for Wednesday, August 20

The books have pegged Toluca as the favorites in the moneyline 3-way market. The Red Devils are listed at +100 to win, while Orlando is priced at +270. If both sides are deadlocked after the 90-minute frame, the draw is penciled in at +225. 

Toluca vs. Orlando City SC Odds

The following odds are taken from bet365 sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose. Read our bet365 sportsbook review and get more info.

Toluca vs. Orlando City SC Betting Prediction

Toluca Preview

Saturday evening, Jesus Angulo rescued a point for his squad with his left-footed shot in the 67th minute that found the back of the net against Pumas UNAM. The 1-1 draw saw Toluca extend their unbeaten run to five between Liga MX and Leagues Cup play. The Red Devils frequently feature on the scoreboard through five Apertura contests, amassing 13 goals in the top-flight division. 

In League Cup play, Paulinho is tied at the top of the goals category, breaching the opposing keeper on four occasions. The 32-year-old possesses one of the most threatening boots when he graces the turf. Since joining Toluca, Paulinho has created attacking opportunities for his employers. In 50 career outings with the Red Devils across all competitions, Paulinho has stockpiled 35 goals and nine assists.

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Orlando City SC Preview

Óscar Pareja has earned the most of his troops in the 2025 season. The Lions are experiencing another solid MLS campaign, which has the club tied for third place in the Eastern Conference table. Over the weekend in domestic action, the weather-delayed tilt saw Orlando crush its counterpart, Sporting Kansas City, cruising to a 3-1 victory. 

Of the 53 goals Orlando City SC has bagged in MLS, 14 have been scored by Martin Ojeda. His third campaign in a Lions’ kit has seen the 26-year-old midfielder break out into a star, obtaining 14 goals in MLS, which is more than double his career high which he achieved in 2023, netting six goals.

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Toluca vs. Orlando City SC - My Pick

• Toluca vs. Orlando City SC pick: Toluca ML 3-way (+100) at bet365

Entering this quarterfinals bout, the pair in this fixture are executing their performances on the pitch. We feel the edge points towards the reigning Liga MX champions, Toluca. Orlando has its fair share of quality, but compared to Toluca, the Red Devils command the edge with their relentless ability to hit the back of the net. Toluca’s dangerous attack could spell bad news for Orlando, as they have failed to keep a clean sheet in their previous 12 matches in all competitive matches. We sense Toluca’s winning pedigree of late pushes them across the finish line into the semis.

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How to Watch Toluca vs. Orlando City SC

• When: August 20, 9 p.m. ET

• Where: Dignity Health Sports Park

• TV: Apple TV - MLS Season Pass, Apple TV+