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Anytime Touchdown Scorer Predictions in Week 15: Back the Bills to Light Up the Scoreboard

Published: December 10, 2025, 09:30 AM ET
5 min read
  • James Cook averaged 4.44 Yards per Carry in last week’s win against Cincinnati

  • The New England Patriots have a two game lead for first in the AFC East

  • The Patriots' defense ranks below league average in Run Defense PFF Grade

After failing to score in last week’s thrilling 39-34 win over the Cincinnati Bengals, James Cook has the opportunity to find the back of the end zone on Sunday as he faces off against the New England Patriots who struggle to stop the run. Especially with the Bills expected to get into scoring position at a high rate as this will lead to an uptick in Cook’s total number of Red Zone Carries.

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Anytime Touchdown Scorer Predictions Week 15 James Cook

James Cook Anytime Touchdown Scorer (-125) at BetMGM Sportsbook

Even though James Cook was held out of the end zone, he still put together a dominant performance in their win over Cincinnati as he finished the contest with 80 Rushing Yards while averaging 4.44 Yards per Carry. A high level of play that we have been accustomed to from Cook this season as the Bills running back ranks top-5 in Yards Over Expected per Attempt.

In an AFC East divisional matchup against New England, expect Cook to capitalize on his heavy workload when inside the 20 as he faces off against a Patriots front seven who ranks below league average in Run Defense PFF Grade. For some more exposure, escalator bet Cook’s Anytime Touchdown Scorer prop by placing smaller wagers on his alternate totals at the best available odds across multiple sportsbooks.

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Mark Andrews Anytime Touchdown Scorer (+155) at BetMGM Sportsbook

Even after re-tooling their offense, Mark Andrews has still been Lamar Jackson’s favorite pass catcher to throw near the goal line as the Baltimore Ravens tight end comfortably leads the team in total Red Zone Targets with a 58.3% Usage Rate. When Lamar looks his way, Andrews has been able to capitalize on his scoring opportunities as he has converted 80% of his Receptions into touchdowns.

While their offense has sputtered the past few weeks, positive regression looms large on Sunday as the Ravens face off against the Cincinnati Bengals who rank dead last in Def DVOA and in EPA. With the Bengals forced to stack the box in an attempt to slow down Derrick Henry, Andrews will be able to take advantage of the single coverage he receives and exploit their gaps in coverage.

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Puka Nacua Anytime Touchdown Scorer (-135) at BetMGM Sportsbook

Since the start of the regular season, the Los Angeles Rams have quickly built a case for being listed as the betting favorite to win the Super Bowl, as they possess one of the more formidable offenses in the league. Especially with Matthew Stafford playing at an NFL MVP award winning level as the Rams quarterback ranks top-10 in Quarterback EPA per play and in Big Time Throw Percentage.

In his return to Detroit, expect Stafford to continue to thrive as he faces off against a Lions defense who resides near the bottom of the board in Pass Rush Win Rate. With minimal pressure crashing down on Stafford in the interior, Puka Nacua will have extra time in the open field to break away from their coverage which will help increase the quality of his passing lanes.

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Christian McCaffrey to Record 2+ Touchdowns (+170) at BetMGM Sportsbook

Since Brock Purdy made his return from injury, Christian McCaffrey has been able to round back into form as opposing defenses are no longer able to consistently stack the middle. With the Tennessee Titans ranking well below league average in Run Defense Line Yards, McCaffrey will be able to generate a higher volume of explosive runs which increases his chances of clearing the over on his alternate touchdown scoring prop.

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Kody Malstrom

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Kody Malstrom is a sports betting journalist with six years of writing experience in the industry. He covers an abundance of sports, including College Football, NFL, College Basketball, NBA, and more. Born and raised in Michigan, Kody is a devoted Detroit Sports fan and spends his Sundays rooting for the Detroit Lions while telling himself this year is the year they win it all. When not staring at betting markets, Kody spends his free time at the beach in the summer or snowboarding in the winter.
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