NFL Preseason Week 2 Picks and Predictions: How Will Shedeur Follow Great Game, and Which Stars Are Playing?

• The Commanders had the worst loss of Preseason Week 1 against the Patriots, 48-18

• Underdogs went 12-4 against the spread last week

• More starters and star players are expected to play this week

It's finally starting to feel like football is back, and I’ve prepared my best bets for every game in Week 2 of the NFL preseason. 

I started the new year with a winning record of 9-7 in Week 1. That included several underdog moneyline wins, and dogs overall went 12-4 against the spread. Whether or not that will be a sign of what is to come or just a flash in the pan remains to be seen.

With more star players expected to suit up and knock off the rust before the regular season begins in less than a month, here are my best spread, moneyline, and total bets for the NFL preseason Week 2.

NFL Preseason Week 2 Picks

• Cleveland Browns vs. Philadelphia Eagles ML (-125)

• New York Jets vs. New York Giants over 38.5 points (-110)

• Jacksonville Jaguars -2.5 (-110) vs. New Orleans Saints

• And more…

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NFL Preseason Week 2 Predictions and Odds

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Titans vs. Falcons - Aug. 15, 7:00 p.m. ET

Spread: Titans -3 (-115), Falcons +3 (-105) 

Moneyline: Titans -170, Falcons +145

Total: Over/under 36.5 (-110/-110)

The Titans’ offense unsurprisingly failed to gather any momentum against a super Buccaneers team in one of our several correct upset picks. The Falcons, meanwhile, were efficient offensively but failed to turn that into successful scoring drives. There’s still great value on the Falcons here, considering they looked better and have the potential to hit a higher level if they play their starters.

• Titans vs. Falcons pick: Falcons +3 (-105) at bet365

Chiefs vs. Seahawks - Aug. 15, 10:00 p.m. ET

Spread: Chiefs -2.5 (-115), Seahawks +2.5 (-105)

Moneyline: Chiefs -155, Seahawks +130

Total: Over/under 40.5 (-110/-110)

So what Bailey Zappe and Gardner Minshew didn’t look great, they’re still elite quarterbacks by preseason standards. Drew Lock and Jalen Milroe are also quality options for this context, while neither defense looked great in their first piece of action. Although this is a large total for the preseason, the over is still calling out as an attractive option.

• Chiefs vs. Seahawks pick: Over 40.5 points (-110) at bet365

Browns vs. Eagles - Aug. 16, 1:00 p.m. ET

Spread: Browns +1.5 (-110), Eagles -1.5 (-110)

Moneyline: Browns +105, Eagles -125

Total: Over/under 37.5 (-110/-110)

Shedeur Sanders showed enough to prove he warrants playing time at some point during the season, but he also missed some easy throws and didn’t command the pocket during the first quarter. Tanner McKee, meanwhile, looks like he could be the best backup quarterback in the league. Philly’s defense is suspect, but this is still a nice spot to grab the Birds as outright winners.

• Browns vs. Eagles pick: Eagles ML (-125) at bet365

Dolphins vs. Lions - Aug. 16, 1:00 p.m. ET

Spread: Dolphins -1.5 (-115), Lions +1.5 (-105)

Moneyline: Dolphins -135, Lions +115

Total: Over/under 36.5 (-110/-110)

A wet coat turning into a fresh white wall could’ve been more entertaining viewing than the display Quinn Ewers put forth for the Dolphins. He and his teammates will face a Lions team that hasn't looked great at any point during the preseason, but that has two games of reps under its belt. I’d recommend a long, hard look at the underdogs here.

• Dolphins vs. Lions pick: Lions +1.5 (-105) at bet365

Packers vs. Colts - Aug. 16, 1:00 p.m. ET

Spread: Packers +4.5 (-110), Colts -4.5 (-110)

Moneyline: Packers +175, Colts -210

Total: Over/under 39.5 (-110/-110)

The Packers could barely pass the ball in a 30-10 loss to the New York Jets in Week 1, but they are better than what they showed. The Colts still have a QB carousel of an injured Anthony Richardson, Daniel Jones, and Riley Leonard. With neither team in a great situation and the Packers having reason to respond, the under feels like a solid pick.

• Packers vs. Colts pick: Under 39.5 points (-110) at bet365

Patriots vs. Vikings - Aug. 16, 1:00 p.m. ET

Spread: Patriots +1.5 (-110), Vikings -1.5 (-110)

Moneyline: Patriots +105, Vikings -125

Total: Over/under 38.5 (-110/-110)

The Pats dominated the point of attack and beat the Commanders in every way in their first bit of preseason action. Sam Howell had a nice opener for the Vikings, and their defense only allowed 10 points. This also feels like an under as the Patriots’ scoring was largely supported by special teams and interceptions in plus-territory.

• Patriots vs. Vikings pick: Under 38.5 points (-110) at bet365

Panthers vs. Texans - Aug. 16, 1:00 p.m. ET

Spread: Panthers +2 (-110), Texans -2 (-110)

Moneyline: Panthers +115, Texans -135

Total: Over/under 37.5 (-110/-110)

The Panthers’ offense was limited but not bad by preseason standards, while their defense struggled to stop the run. The Texans were hamstrung by Graham Mertz’s three interceptions, but there’s reason to believe he won’t be that bad again. The Texans’ moneyline could prove to be a worthy risk.

• Panthers vs. Texans pick: Texans ML (-135) at bet365

49ers vs. Raiders - Aug. 16, 4:00 p.m. ET

Spread: 49ers +3.5 (-110), Raiders -3.5 (-110)

Moneyline: 49ers +160, Raiders -190

Total: Over/under 40.5 (-110/-110)

There basically weren’t any positives from the Niners’ first outing, a 30-9 loss to the Broncos. The Raiders, on the other hand, were productive and scored 23 points, which is a solid amount for the preseason. I’d take the favorites to continue their reinvention under Pete Carroll with a commanding win.

• 49ers vs. Raiders pick: Raiders -3.5 (-110) at bet365

Jets vs. Giants - Aug. 16, 7:00 p.m. ET

Spread: Jets -1 (-110), Giants +1 (-110)

Moneyline: Jets -120, Giants +100

Total: Over/under 38.5 (-110/-110)

The battle for the Hudson River sees the Jets favored after they demolished the Packers through a strong offensive performance. The Giants’ rookies, namely Abdul Carter and Jaxson Dart, looked impressive in Game 1, and they scored 34 points against the Bills. This game sets up to cash the over after the two scored 64 combined points last week. 

• Jets vs. Giants pick: Over 38.5 points (-110) at bet365

Ravens vs. Cowboys - Aug. 16, 7:00 p.m. ET

Spread: Ravens -3 (-110), Cowboys +3 (-110)

Moneyline: Ravens -170, Cowboys +145

Total: Over/under 36.5 (-110/-110)

Baltimore is normally a preseason juggernaut, but they looked atrocious through the air and will rely heavily on running the ball. Joe Milton III will make plays for the Cowboys, but he will also make mistakes. If I’m reading this game correctly, it has the under written all over it.

• Ravens vs. Cowboys pick: Under 36.5 points (-110) at bet365

Chargers vs. Rams - Aug. 16, 7:00 p.m. ET

Spread: Chargers -3.5 (-105), Rams +3.5 (-115)

Moneyline: Chargers -160, Rams +135

Total: Over/under 35.5 (-110/-110)

The Chargers are 2-0 in the preseason and scored an average of 30.5 points per game thanks to Trey Lance’s confident play under Jim Harbaugh. The Rams have talented running options, and Stetson Bennett IV played alright against the Cowboys, so this game could prove to be fairly close. Taking the Rams on the spread due to the value of their 3.5-point line seems like a savvy play.

• Chargers vs. Rams pick: Rams +3.5 (-115) at bet365

Buccaneers vs. Steelers - Aug. 16, 7:00 p.m. ET

Spread: Buccaneers -1.5 (-110), Steelers +1.5 (-110)

Moneyline: Buccaneers -130, Steelers +110

Total: Over/under 37.5 (-110/-110)

The Bucs took a little to get going but poured it on against the Titans, winning 29-7 thanks to a dominant effort on the ground. The Steelers, meanwhile, got an outstanding showing from Skylar Thompson, although their defense was nothing if not porous. The Bucs were my favorite pick in Week 1, and although I’m not as confident in them this week, I’m willing to take them straight up against the Steelers.

• Buccaneers vs. Steelers pick: Buccaneers ML (-130) at bet365

Cardinals vs. Broncos - Aug. 16, 9:30 p.m. ET

Spread: Cardinals +3.5 (-110), Broncos -3.5 (-110)

Moneyline: Cardinals +160, Broncos -190

Total: Over/under 39.5 (-110/-110)

Kyler Murray ironically did not help his team win their first preseason game against the Chiefs, 20-17, but that could be a sign that they will be even better in Week 2. Bo Ni similarly did not contribute to his team’s rout of the 49ers, which sets up an intriguing battle by preseason standards. I’d look at the under in this game since the QBs didn’t come out firing.

• Cardinals vs. Broncos pick: Under 39.5 points (-110) at bet365

Jaguars vs. Saints - Aug. 17, 1:00 p.m. ET

Spread: Jaguars -2.5 (-110), Saints +2.5 (-110)

Moneyline: Jaguars -140, Saints +120

Total: Over/under 37.5 (-110/-110)

The Jags managed to score 25 points on the Steelers last week despite none of their four quarterbacks producing 100 yards passing. The Saints, meanwhile, lost 27-13 to the Chargers with what looks to be an unsurprisingly terrible offense. This is a terrible sign for the Saints, who will have to start one of these QBs in Week 1, but I’d back the Jags.

• Jaguars vs. Saints pick: Jaguars -2.5 (-110) at bet365

Bills vs. Bears - Aug. 17, 8:00 p.m. ET

Spread: Bills +2 (-110), Bears -2 (-110)

Moneyline: Bills +110, Bears -130

Total: Over/under 38.5 (-110/-110)

It’s hard to fault the Bills’ QB room, but their defense surrendered 34 points to the Giants. The Bears have capable QBs of their own with Tyson Bagent and Case Keenum, but they somehow surrendered 24 points to a Dolphins team that only went 15-33 for 171 yards through the air. I’d back the Bills here, especially seeing as they are the more established of the two programs.

• Bills vs. Bears pick: Bills +2 (-110) at bet365

Bengals vs. Commanders - Aug. 18, 8:00 p.m. ET

Spread: Bengals -2.5 (-115), Commanders +2.5 (-105)

Moneyline: Bengals -150, Commanders +125

Total: Over/under 40.5 (-110/-110)

Joe Burrow and the Bengals’ starters are expected to get some burn against the Commanders, but they just got all they could handle from the Eagles’ backups and Tanner McKee in a 34-27 loss. The Commanders had the worst loss of Week 1, a 30-point disaster-class against the Patriots, but Dan Quinn promised a different look in Week 2. Washington still has issues it needs to sort out, and I’d roll with the Bengals.

• Bengals vs. Commanders pick: Bengals -2.5 (-115) at bet365

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