Inter Miami CF vs. Vancouver Whitecaps FC Prediction: Which Superstar Will Hoist the MLS Cup - Messi or Müller?

• Inter Miami cruised past NYCFC to get to the final stage for the first time in club history

• Vancouver Whitecaps will be participating in their third title match across all competitions in 2025 

History will be made on Saturday at Chase Stadium, where Inter Miami CF welcomes the Vancouver Whitecaps FC in a battle for the league crown. Both opponents will be making their MLS Cup final debuts, with the opportunity to add the Philip F. Anschutz Trophy to their cabinet. 

Here, we will break down the betting odds and share our favourite picks for Inter Miami CF vs. Vancouver Whitecaps FC.

Inter Miami CF vs. Vancouver Whitecaps FC Betting Odds for December 6

Inside the 90-minute frame, the hosts find themselves pegged as the favourites, priced at -125 to win. The visitors are listed at +270 to pull off the upset; if both sides are deadlocked after regulation time, the draw is pencilled in at +320.

Inter Miami CF vs. Vancouver Whitecaps FC Odds

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Inter Miami CF vs. Vancouver Whitecaps FC Betting Prediction

Inter Miami CF Preview

Last weekend, Javier Mascherano’s men completely dismantled NYCFC in the Eastern Conference finals, winning by a massive 5-1 margin. The Herons left no room for errors, striking early with two goals before the 25-minute mark and never looking back. The triumph that sent Vice City to their first MLS Cup appearance was the club's 10th victory in their previous 14 matches. 

The unexpected hero last Saturday, who carried his club to victory, Tadeo Allende, put in a class display that culminated in a hat-trick. The 26-year-old forward is heating up at the right time down the stretch. His previous three playoff outings have seen him hit the back of the net on seven occasions. For Messi’s standards, it was a quiet evening on the pitch against NYCFC, as he was held off the scorers’ sheet for the first time since October 4, halting his six-game tally streak. The Argentinian legend only obtained a single assist in his 90-minute shift on Saturday.

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Vancouver Whitecaps FC Preview

Rolling into the Western Conference finals, the cards looked to be stacked against Jesper Sørensen’s troops. Having to square up against a juggernaut club like San Diego FC on their home soil without the services of the MLS’s defender of the year, Tristan Blackmon. Early pressure from the ‘Caps high press saw them jump out to an early 2-0 lead before the quarter mark of the match. A three-goal lead before the break was enough to book Vancouver in the 2025 MLS Cup final, getting the better of the expansion side, finishing 3-1.

The Whitecaps' regular-season leading goal getter from this term, Brian White, got the party started in the eighth minute, hitting home his first goal of the postseason. As the first half was closing, the USMNT product was able to breach the keeper, giving his side a comfortable three-goal lead. Setting up White’s pair of goals, Ali Ahmed and Andrés Cubas each cataloged an assist, playing an influential part in the squads victory with Ahmed’s searing pace along the wings and Cuba’s complex, nose-to-nose, steady play controlling the middle of the field. Throughout all competitive fixtures, Vancouver has received contributions from its group, scoring at least a goal in 22 consecutive matches.

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Inter Miami CF vs. Vancouver Whitecaps FC - My Pick

• Inter Miami CF vs. Vancouver Whitecaps FC pick: Inter Miami CF moneyline 3-way (-125) at bet365

In February, before the campaign kicked off, the preseason odds had Vancouver nowhere near the title-contenders list, but the club had overcome hurdles. Injuries have plagued them all year, and they have been a great story in 2025, but we feel their run will end this Saturday. Despite losing only once since signing Müller, Vice City is loaded up front, with no shortage of skill and quality. Messi doesn’t have to carry Inter Miami with the solid form Allende and Silvetti are manufacturing on his wings. 

The Herons are just running roughshod over their playoff adversaries, winning three straight matches by a four-goal margin. This uptick in playoff scoring is no fluke, as Miami stockpiled 81 goals during the regular season. At home, the Herons are a force to be reckoned with; they are a talented group like Vancouver. The revenge factor also plays into our wager backing the hosts. Earlier in 2025, Vancouver knocked out Messi and Co. during the 2025 CONCACAF Champions Cup, 5-1 on aggregate. Messi and his colleagues should get the last laugh on Saturday.

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How to Watch Inter Miami CF vs. Vancouver Whitecaps FC

• When: December 6, 2.30 p.m. ET

• Where: Chase Stadium

• TV: Fox, MLS Season Pass, Apple TV