Inter Miami CF vs. LA Galaxy Prediction: Both Teams Aim to Regroup After Heavy Defeats

• Messi-less Inter Miami were trashed entirely by their in-state rivals during round 26

• The LA Galaxy saw their winless run in MLS extend to three matches 

Saturday evening, a marquee encounter will occur at Chase Stadium as Inter Miami CF welcomes the defending MLS Cup winners, the LA Galaxy. These sides have only ever met twice, with the Herons failing to win in both instances. 

Here, we will break down the betting odds and share our favorite picks for Inter Miami CF vs. LA Galaxy. 

Inter Miami CF vs. LA Galaxy Betting Odds for Saturday, August 16

The books have pegged the home side as the firm favorite in the moneyline 3-way market. Vice City are priced at -154 to win while the Galaxy are listed at +320. If both clubs are deadlocked after the final whistle, the draw is marked down at +350. 

Inter Miami CF vs. LA Galaxy Odds

The following odds are taken from bet365 Sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose.

Inter Miami CF vs. LA Galaxy Betting Prediction

Inter Miami CF Preview

The Florida derby saw Javier Mascherano’s men suffer one of their most atrocious setbacks in 2025, losing 4-1 against Orlando City SC on Sunday. From the opening kickoff, the Herons were disjointed with the absence of their eight-time Ballon d'Or winner, Lionel Messi. In the 90 minutes, Miami struggled to create meaningful chances while looking erratic on the backend, allowing 21 shots fired at their net. 

With Messi potentially missing this weekend's clash, the likes of Luis Suárez and Tadeo Allende will need to improve their performance to another level. The duo who will be counted on have contributed to Vice City’s offense, combining for 23 goal contributions.

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LA Galaxy Preview

The hangover from last year’s title win for Greg Vanney’s troops is still lingering throughout the MLS campaign. Over the weekend, the Galaxy were embarrassed on their home pitch, suffering a 4-0 thumping against the Seattle Sounders. Regarding accumulated points, LA has obtained the lowest amount out of the competition's 30 teams, only securing 16. 

Joining the Galaxy late in 2024 en route to lifting the MLS Cup, Marco Reus has found his footing in this campaign. Despite the disappointing title defense for the Galaxy, the ex-Borussia Dortmund man is doing his part on the stat sheet. Through 19 MLS outings, the German international has catalogued five goals and seven assists 

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Inter Miami CF vs. LA Galaxy - My Pick 

• Inter Miami CF vs. LA Galaxy pick: Inter Miami CF moneyline 3-way (-154) at bet365 

Although Messi could be a game-time decision, we feel Inter Miami are in a favourable spot to garner all three points on Saturday. From what we have witnessed in the Galaxy’s away performances this campaign, this is another situation to go against them. Through 13 league away games in 2025, the Galaxy have yet to achieve a win, and at the same time, their back line is prone to conceding, surrendering 30 goals. After getting embarrassed by their Florida state counterpart, we feel the Herons will follow up with a solid performance, now having a regular scheduled week to get back to their tactics which has been attributed to seeing them stockpile wins, this is the time to back the hosts at a responsible price.

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How to Watch Inter Miami CF vs. LA Galaxy

• When: August 16 at 7:30 p.m. ET

• Where: Chase Stadium 

• TV: Apple TV, MLS Season Pass