AFC South Odds, Predictions, Betting Picks 2025/26: Celebrating the Daniel Jones Experiment

• Daniel Jones has completed 71.6% of his passes for 816 yards and three TDs

• The Jaguars' defense dominated against the Texans in Week 3

• Pre-season favorite Houston has started the season 0-3

There have been some significant stories from the first three weeks of the NFL season, but none bigger than the success of Daniel Jones. The former Giants quarterback has been elite, providing the Colts with the piece they were missing after Anthony Richardson failed to meet high expectations. That has Indy atop the division standings, but can that success last? 

Below, we’ll preview the AFC South heading into the 2025 season. We’ll discuss how we envision the 2025 season unfolding and our pick for the winner.

If you’re looking for a reliable platform to place your AFC South wager, we recommend Caesars Sportsbook. If you’d like to try Caesars, use promo code WSNDYW to claim a “Bet $1, Get Ten 100% Profit Boost Tokens” offer.

Discover our podcast, Ride the Line, which is dedicated to all things sports and sports betting. Dive into Grant and Tanner's expert selections for the AFC South.

AFC South Odds

Odds from Caesars Sportsbook. Use our promo code WSN20X to sign up for a Caesars account and claim the welcome offer: Bet $1, Double Your Winnings Next 20 Bets.

AFC South Predictions

Our entire view of this division has changed over the last two weeks. One significant reason for this is the performance of the 3-0 Indianapolis Colts. The defense has been far better than we expected, but the biggest story has been the success of Daniel Jones. The Giants’ reject has completed 71.6% of his passes for 816 yards and three touchdowns without an interception. He’s also been using his legs, adding another 55 yards and three touchdowns on the ground.

While many people continue to doubt Jones’s ability to maintain this pace, we do. That’s because of the team’s pass-catching playmakers, including Tyler Warren, Michael Pittman, and Josh Downs. Add in healthy Jonathan Taylor, and this team suddenly becomes one of the most balanced in football. That will help the Colts to a surprising division win, and could make Daniel Jones a valid MVP candidate. 

The Jags picked up a massive road win against the Texans on Sunday, thanks to their defense. They limited Houston to 271 yards while forcing three turnovers, including a red-zone interception on Houston’s final drive with 26 seconds left. However, the team’s offense continues to underwhelm. The team’s 2-1 record will keep them in the division race, but we don’t see this team having the balance needed to beat the Colts.

Speaking of the Texans, the time for panic has come and gone. The team is 0-3, thanks to the offense posting the third-fewest yards in the league. It doesn’t seem like Houston’s offensive line can protect Stroud, which negates the young quarterback and the team’s explosive pass attack.

We expect Houston to pick up its first win at home against the Titans in Week 4, but the losses will pile up after, as Houston faces the Ravens, Seahawks, Niners, and Broncos.

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AFC South Winner - My Pick

Indianapolis Colts (-150) at BetMGM Sportsbook

The Colts have gained the second-most yards in the NFL through three weeks (1,260), and allowed the seventh-lowest on defense (817). That proves the balance this roster has, which will help them navigate a schedule that was ranked as one of the top ten easiest in the league. 

While we have concerns about Jones’s ability to maintain this level of play throughout the season, this team has enough weapons to thrive even if he regresses. Combine that with the struggles of Indy’s three division rivals, and you can see why we are locking this bet in.

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How to Bet on the AFC South

Betting on the AFC South is a fairly simple task for bettors of all backgrounds, but learning where to find and place these bets can take time. If you find yourself stuck, we have you covered. 

Here is an easy step-by-step guide to help you get started:

1. Choose the sportsbook you want to wager with

2. Select “Football” or “NFL” from the betting catalog, usually found on the top or side menu

3. Click on the tab for “Futures”

4. Read through the options for the “Division Winner” section

5. Scroll down until you find the AFC South

6. Select the team you think will win

7. Navigate to your betslip to enter how much you want to wager

8. Hit submit, and you are all set!

All division futures bets will be paid out once the season ends and a champion is officially crowned. 

How to Read AFC South Odds

NFL futures odds work the same as any other bet. Each bet includes a number following the team or player, preceded by a plus or minus sign. 

A plus sign before the number usually indicates an underdog, which is common with futures bets. If the odds next to a team or player have a plus sign, that is the amount that you will win for every $100 you bet.

A minus sign usually indicates the favorite to win, though they are rarely seen for future bets. A minus sign in front of the odds means that is how much you need to bet to win $100.

For example, you bet $100 on the Texans at +110 to win the AFC South. If they win the division, you will win $110. 

If you aren't looking to bet $100 at a time, don't worry! Check out our odds calculator to help you determine potential winnings based on different wager amounts.

Where to Bet on the AFC South

Are you ready to start betting on the AFC South but unsure where to start? If so, we have you covered with our sportsbook reviews. Here are our three favorite sportsbooks we use when betting on NFL futures:

• BetRivers Sportsbook: This sportsbook has been one of the few success stories from mid-size operators in the US. The platform isn’t as sharp as FanDuel or BetMGM, but it offers bettors some fantastic bonuses and very competitive odds. If you are looking for a smaller and more player-friendly platform, we highly recommend BetRivers. Follow our link to claim the promo offer: $500 Bonus Bet.

• FanDuel Sportsbook: If you are betting on America’s favorite sport, why not use its favorite sportsbook? FanDuel offers bettors an easy-to-use platform that is easy to navigate. The odds, promotions, and rewards are unmatched, meaning you can have more money in your pocket when you win. Use our link to register and claim the promo offer: Bet $5, Get $300 in Bonus Bets if Your Bet Wins.

• Caesars Sportsbook: Caesars offers one of the best NFL betting experiences in the industry. The Las Vegas sportsbook has a flashy platform that lets you easily find games, place wagers, and follow your bets. Caesars also offers the ability to live stream most NFL games from their app, allowing you to watch games on the go. Use our promo code WSN20X and claim the following offer: Bet $1, Double Your Winnings Next 20 Bets.

AFC South Winner History

The Texans won their second consecutive AFC South title in 2024. Caesars has the Texans as an early favorite to win another in 2025, but they’ll face an improved division.

Below are the last ten teams to win the AFC South.