AFC South Odds, Predictions, Betting Picks 2025/26: Can the Texans Protect CJ Stroud?

• The Texans allowed the third-most sacks in the NFL last season

• Travis Hunter is expected to start at receiver for the Jags

• Colts’ Rookie Tyler Warren has taken over the starting tight end spot

The AFC South race may not be the prettiest in 2025, but it should be thrilling to watch. The Houston Texans will be looking to remain on top, but have significant concerns about their offensive line. Will they be able to fend off an improved division once again this season?

Below, we’ll preview the AFC South heading into the 2025 season. We’ll discuss how we see the 2025 season play out and our pick to win.

AFC South Odds

Odds from Caesars Sportsbook. Use our promo code WSNDYW to sign up for a Caesars account and claim the welcome offer: Bet $1, Get 10 100% Profit Boost Tokens.

AFC South Predictions

The Texans will once again enter the season with a dominant defense. We love that they added receiving depth in the draft, but we still have questions about the offensive line, which allowed the third-most sacks last season (54).  Laremy Tunsil is gone, and now Cam Robinson may be dealing with a serious injury from training camp. The unit doesn’t have much depth, and could ultimately prove to be the Texans’ Achilles heel. 

We are VERY excited to see the Jacksonville Jaguars offense in 2025. The unit has disappointed over the last two seasons, but it has two young and electric receivers leading the way. Brian Thomas Jr. looked like a star in his rookie 2024 season, finishing with 1,282 yards and 10 touchdowns. Now he’ll be joined by second-overall pick Travis Hunter, who is expected to shine on both sides of the ball this year.

We don’t see the Indianapolis Colts competing with the Jags and Texans this season, but don’t count on them being an easy out in 2025. First-round selection Tyler Warren is expected to start at tight end after impressing in training camp. His presence could help Anthony Richardson Jr, as well as help open up space for the team’s receivers. 

There is a lot of excitement around the Titans and top overall draft pick Cam Ward. The rookie has fans excited to see the offense, but the team is desperate for help on defense. Depth to the secondary would be nice, but the most pressing issue is finding an EDGE rusher. It's a significant hole for the team, which has confirmed they are exploring options to bolster the weak spot.

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AFC South Winner - My Pick

Jacksonville Jaguars (+310) at Caesars Sportsbook

There is so much to love about the Texans, but we have seen how bad they are when the offensive line is struggling. The Jags seem to have a stronger unit and will be led by a quarterback that will be hungry to rebound after disappointing the previous two seasons. 

The first half of the Jags' schedule is brutal and could lead to a slow start. However, they’ll face just three playoff teams after their Week 8 bye. That will allow them to make a strong run late in the season, overtaking Houston for the 2025 AFC South title.

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How to Bet on the AFC South

Betting on the AFC South is a fairly simple task for bettors of all backgrounds, but learning where to find and place these bets can take time. If you find yourself stuck, we have you covered. 

Here is an easy step-by-step guide to help you get started:

1. Choose the sportsbook you want to wager with

2. Select “Football” or “NFL” from the betting catalog, usually found on the top or side menu

3. Click on the tab for “Futures”

4. Read through the options for the “Division Winner” section

5. Scroll down until you find the AFC South

6. Select the team you think will win

7. Navigate to your betslip to enter how much you want to wager

8. Hit submit, and you are all set!

All division futures bets will be paid out once the season ends and a champion is officially crowned. 

How to Read AFC South Odds

NFL futures odds work the same as any other bet. Each bet includes a number following the team or player, preceded by a plus or minus sign. 

A plus sign before the number usually indicates an underdog, which is common with futures bets. If the odds next to a team or player have a plus sign, that is the amount that you will win for every $100 you bet.

A minus sign usually indicates the favorite to win, though they are rarely seen for future bets. A minus sign in front of the odds means that is how much you need to bet to win $100.

For example, you bet $100 on the Texans at +110 to win the AFC South. If they win the division, you will win $110. 

If you aren't looking to bet $100 at a time, don't worry! Check out our odds calculator to help you determine potential winnings based on different wager amounts.

Where to Bet on the AFC South

Are you ready to start betting on the AFC South but unsure where to start? If so, we have you covered with our sportsbook reviews. Here are our three favorite sportsbooks we use when betting on NFL futures:

• BetRivers Sportsbook: This sportsbook has been one of the few success stories from mid-size operators in the US. The platform isn’t as sharp as FanDuel or BetMGM, but it offers bettors some fantastic bonuses and very competitive odds. If you are looking for a smaller and more player-friendly platform, we highly recommend BetRivers. Follow our link to claim the promo offer: $500 Bonus Bet.

• FanDuel Sportsbook: If you are betting on America’s favorite sport, why not use its favorite sportsbook? FanDuel offers bettors an easy-to-use platform that is easy to navigate. The odds, promotions, and rewards are unmatched, meaning you can have more money in your pocket when you win. Use our link to register and claim the promo offer: Bet $5, Get $300 in Bonus Bets if Your Bet Wins.

• Caesars Sportsbook: Caesars offers one of the best NFL betting experiences in the industry. The Las Vegas sportsbook has a flashy platform that lets you easily find games, place wagers, and follow your bets. Caesar’s also offers the ability to live stream most NFL games from their app, allowing you to watch games on the go. Use our promo code WSNDYW and claim the following offer: Bet $1, Get 10 100% Profit Boost Tokens.

AFC South Winner History

The Texans won their second consecutive AFC South title in 2024. Caesars has the Texans as an early favorite to win another in 2025, but they’ll face an improved division.

Below are the last ten teams to win the AFC South.