AFC South Odds, Predictions, Betting Picks 2025/26: Jacksonville Jaguars Lead AFC South Division

• Jaguars (8-4) took first place with a win over the Titans and a Colts loss, leading on tiebreakers (common games)

• Colts (8-4) dropped to a tie for second place after losing to the Texans, but still hold the tiebreaker for the 2nd spot

• Texans (7-5) vaulted to third place with their critical win over the Colts, closing the gap in the division race

AFC South Odds

The odds have been taken from the FanDuel sportsbook. Register at FanDuel and claim the following welcome bonus: Bet $5, Get $150 in Bonus Bets if Your Bet Wins.

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AFC South Winner - My Pick

Indianapolis Colts (+140) at FanDuel Sportsbook

Despite their recent slump, the Colts are considered a favorable betting candidate because they control their own destiny due to a backloaded schedule featuring three crucial divisional games, including two against the co-leading Jaguars. A strong conference record (6-3 AFC) and a top-scoring offense also provide key tiebreaker advantages and high upside if they can regain their early-season form.

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How to Bet on the AFC South

Betting on the AFC South is a fairly simple task for bettors of all backgrounds, but learning where to find and place these bets can take time. If you find yourself stuck, we have you covered. 

Here is an easy step-by-step guide to help you get started:

1. Choose the sportsbook you want to wager with

2. Select “Football” or “NFL” from the betting catalog, usually found on the top or side menu

3. Click on the tab for “Futures”

4. Read through the options for the “Division Winner” section

5. Scroll down until you find the AFC South

6. Select the team you think will win

7. Navigate to your betslip to enter how much you want to wager

8. Hit submit, and you are all set!

All division futures bets will be paid out once the season ends and a champion is officially crowned. 

How to Read AFC South Odds

NFL futures odds work the same as any other bet. Each bet includes a number following the team or player, preceded by a plus or minus sign. 

A plus sign before the number usually indicates an underdog, which is common with futures bets. If the odds next to a team or player have a plus sign, that is the amount that you will win for every $100 you bet.

A minus sign usually indicates the favorite to win, though they are rarely seen for future bets. A minus sign in front of the odds means that is how much you need to bet to win $100.

For example, you bet $100 on the Texans at +110 to win the AFC South. If they win the division, you will win $110. 

If you aren't looking to bet $100 at a time, don't worry! Check out our odds calculator to help you determine potential winnings based on different wager amounts.

Where to Bet on the AFC South

Are you ready to start betting on the AFC South but unsure where to start? If so, we have you covered with our sportsbook reviews. Here are our three favorite sportsbooks we use when betting on NFL futures:

• BetRivers Sportsbook: This sportsbook has been one of the few success stories from mid-size operators in the US. The platform isn’t as sharp as FanDuel or BetMGM, but it offers bettors some fantastic bonuses and very competitive odds. If you are looking for a smaller and more player-friendly platform, we highly recommend BetRivers. Follow our link to claim the promo offer: $500 Bonus Bet.

• FanDuel Sportsbook: If you are betting on America’s favorite sport, why not use its favorite sportsbook? FanDuel offers bettors an easy-to-use platform that is easy to navigate. The odds, promotions, and rewards are unmatched, meaning you can have more money in your pocket when you win. Use our link to register and claim the promo offer: Bet $5, Get $150 in Bonus Bets if Your Bet Wins.

• Caesars Sportsbook: Caesars offers one of the best NFL betting experiences in the industry. The Las Vegas sportsbook has a flashy platform that lets you easily find games, place wagers, and follow your bets. Caesars also offers the ability to live stream most NFL games from their app, allowing you to watch games on the go. Use our promo code WSN20X and claim the following offer: Bet $1, Double Your Winnings Next 20 Bets.

AFC South Winner History

The Texans won their second consecutive AFC South title in 2024. Caesars has the Texans as an early favorite to win another in 2025, but they’ll face an improved division.

Below are the last ten teams to win the AFC South.