AFC South Odds, Predictions, Betting Picks 2025/26: The Colts Still Lead the AFC South Division

• Indianapolis Colts maintained their first-place position (7-2 record) despite suffering a loss to the Steelers

• The Jacksonville Jaguars were the only team in the division to win (an overtime victory) and are now in second place with a 5-3 record

• The Houston Texans (3-5) and Tennessee Titans (1-8) both lost their Week 9 games and are at the bottom of the division

AFC South Odds

Odds from Caesars Sportsbook. Use our promo code WSN20X to sign up for a Caesars account and claim the welcome offer: Bet $1, Double Your Winnings Next 20 Bets.

To find the best sites for betting on the NFL and take advantage of the latest bonuses, check out our detailed guide to the best NFL betting sites.

AFC South Winner - My Pick

Indianapolis Colts (-340) at Caesars Sportsbook

The Indianapolis Colts are a favorable betting candidate for the AFC South title due to their high-performing, balanced offense led by a dominant running game and efficient quarterback play, combined with the clear struggles and inconsistency observed among their main division rivals, the Jacksonville Jaguars and Houston Texans, which positions the Colts as the most stable and consistent team with the clearest

Bet $1, Double Your Winnings Next 20 Bets at Caesars

How to Bet on the AFC South

Betting on the AFC South is a fairly simple task for bettors of all backgrounds, but learning where to find and place these bets can take time. If you find yourself stuck, we have you covered. 

Here is an easy step-by-step guide to help you get started:

1. Choose the sportsbook you want to wager with

2. Select “Football” or “NFL” from the betting catalog, usually found on the top or side menu

3. Click on the tab for “Futures”

4. Read through the options for the “Division Winner” section

5. Scroll down until you find the AFC South

6. Select the team you think will win

7. Navigate to your betslip to enter how much you want to wager

8. Hit submit, and you are all set!

All division futures bets will be paid out once the season ends and a champion is officially crowned. 

How to Read AFC South Odds

NFL futures odds work the same as any other bet. Each bet includes a number following the team or player, preceded by a plus or minus sign. 

A plus sign before the number usually indicates an underdog, which is common with futures bets. If the odds next to a team or player have a plus sign, that is the amount that you will win for every $100 you bet.

A minus sign usually indicates the favorite to win, though they are rarely seen for future bets. A minus sign in front of the odds means that is how much you need to bet to win $100.

For example, you bet $100 on the Texans at +110 to win the AFC South. If they win the division, you will win $110. 

If you aren't looking to bet $100 at a time, don't worry! Check out our odds calculator to help you determine potential winnings based on different wager amounts.

Where to Bet on the AFC South

Are you ready to start betting on the AFC South but unsure where to start? If so, we have you covered with our sportsbook reviews. Here are our three favorite sportsbooks we use when betting on NFL futures:

• BetRivers Sportsbook: This sportsbook has been one of the few success stories from mid-size operators in the US. The platform isn’t as sharp as FanDuel or BetMGM, but it offers bettors some fantastic bonuses and very competitive odds. If you are looking for a smaller and more player-friendly platform, we highly recommend BetRivers. Follow our link to claim the promo offer: $500 Bonus Bet.

• FanDuel Sportsbook: If you are betting on America’s favorite sport, why not use its favorite sportsbook? FanDuel offers bettors an easy-to-use platform that is easy to navigate. The odds, promotions, and rewards are unmatched, meaning you can have more money in your pocket when you win. Use our link to register and claim the promo offer: Bet $5, Get $150 in Bonus Bets if Your Bet Wins.

• Caesars Sportsbook: Caesars offers one of the best NFL betting experiences in the industry. The Las Vegas sportsbook has a flashy platform that lets you easily find games, place wagers, and follow your bets. Caesars also offers the ability to live stream most NFL games from their app, allowing you to watch games on the go. Use our promo code WSN20X and claim the following offer: Bet $1, Double Your Winnings Next 20 Bets.

AFC South Winner History

The Texans won their second consecutive AFC South title in 2024. Caesars has the Texans as an early favorite to win another in 2025, but they’ll face an improved division.

Below are the last ten teams to win the AFC South.