49ers vs. Panthers Same Game Parlay Picks: Brock Purdy’s Second Game Back From Injury

• 49ers quarterback Brock Purdy threw three touchdowns and zero interceptions in his return from injury last week. 

• The Panthers are 3-2 on the road as underdogs. 

• 49ers running back Christian McCaffrey is second in the NFL in receptions with 74. 

To close out Week 12 of the 2025-26 NFL season, we have the San Francisco 49ers hosting the Carolina Panthers.

In his return to action after missing almost the entire season, 49ers quarterback Brock Purdy had three touchdown passes.

On the other side, Panthers quarterback Bryce Young had the best game of his career, throwing for nearly 450 yards.

Well above .500, neither team is inside the top 10 in the latest Super Bowl odds. Part of that could be due to ranking 18th or worse in our NFL defense rankings.

49ers vs. Panthers Same Game Parlay Picks

Below, I've constructed a three-same Same Game Parlay for this matchup with +400 odds at BetMGM Sportsbook.

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49ers -7 (-110) at BetMGM Sportsbook

While the Panthers are 3-2 against the spread as a road underdog, I’m taking the 49ers in this spot. 

In his first game back since September last week, 49ers quarterback Brock Purdy completed 19 of 26 passes (73.1%) for 200 yards and three touchdowns. 

Additionally, while Panthers quarterback Bryce Young is coming off the game of his life (and no, that’s hyperbole), throwing for 448 yards and three touchdowns, he’s hard to trust in this spot. 

The 49ers primarily play Cover-3, and against that this season, Young has had a tough go of it, completing 60.9% of his passes for 729 yards, 6.6 yards per attempt, two touchdowns, and four interceptions. 

Add that with the fact that the Panthers are 28th in the NFL in scoring, averaging 18.8 points per game (17.3 on the road), and I think the 49ers could be in for a sizable win.

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Christian McCaffrey Anytime TD (-325) at BetMGM Sportsbook

The odds speak for themselves: McCaffrey has been difficult to stop, scoring five times over his last three games. 

Now, he’s taking on the Panthers, the team that drafted him, and a unit that’s allowing 0.82 rushing touchdowns per game and six over their last four games. 

McCaffrey is the focal point of this offence, averaging more than 24 touches per game. He leads the NFL in carries, and is second, as a running back, in the NFL in receptions with 74. 

He’ll get in the end zone against his former squad. 

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Brock Purdy Over 0.5 INTs (+110) at BetMGM Sportsbook 

Purdy has had limited action this season, playing just three games, but he has four interceptions ot his name. While he didn’t throw one in his return, he threw two in each of his first two starts against the Seattle Seahawks and Jacksonville Jaguars. 

Now, he’ll take on a Panthers defense that averages 0.64 interceptions per game. They last had one in Week 9 against the Packers. 

However, their primary coverage, Cover-3, could be the key to getting a pick. 

Against Cover-3 this season, Purdy has thrown two of his four interceptions. 

Dating back to last season, five of his 12 interceptions in 2024 were against Cover-3. 

This seems to be a coverage he struggles with, so I’ll take the over to help provide a bit more value with McCaffrey’s anytime touchdown at -350. 

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