Best Bears vs. 49ers Prop Bets: Sunday Night Football in San Francisco

• The Bears are leading the NFC North after beating the Packers

• San Francisco has won five games in a row

• The 49ers are favored by a field goal at home

The Bears are coming off one of the biggest wins of the NFL season after knocking off Green Bay, while the 49ers have won five straight games and are playing their best football of the year. San Francisco enters Sunday night as a three-point favorite, with the total set at 52.5.

Best Bears vs. 49ers Prop Bets

Odds for prop bets for the Bears vs. 49ers SNF matchup are courtesy of Fanatics Sportsbook, one of my favorite prop betting sites. New users who join Fanatics today and place a bet at Fanatics will get up to $2,000 in FanCash. Read our Fanatics Sportsbook review for more info.

If you're in a state where Fanatics Sportsbook is not yet legal, we recommend playing at Underdog Fantasy. Read our Underdog Fantasy review and sign up below with promo code WSNPLAY.

Brock Purdy Over 258.5 Passing Yards (-115) at Fanatics Sportsbook

Brock Purdy has been playing excellent football recently, throwing for 295 yards across his last two games. He’s emerged as a true leader for San Francisco, and I expect another strong performance under the lights on Sunday night.

On the season, Purdy has thrown for 1,737 yards with 17 touchdowns and eight interceptions. While his efficiency could improve, he hasn’t hesitated to push the ball downfield in 2025, which is precisely what we want when backing a passing yards prop.

The Bears have been solid against the run but have struggled at times defending the pass. That imbalance sets up well for Purdy to exploit Chicago’s secondary and surpass this number.

Purdy has cleared this line in four of seven games this season, and his production has been encouraging given his lack of receiving weapons. I expect the 49ers to establish McCaffrey early, which should open things up through the air and allow Purdy to cash this prop.

Bet at Fanatics and Get Up to $2,000 in FanCash

D’Andre Swift Over 56.5 Rushing Yards (-115) at Fanatics Sportsbook

D’Andre Swift has been a major factor in Chicago’s success this season, and I’m backing him to eclipse 57 rushing yards once again. He’s hit this prop in four straight games, including a massive 125-yard performance against Philadelphia.

Swift has rushed for 993 yards and seven touchdowns in 2025, serving as the lead back alongside Kyle Monangai. Even with a slight reduction in carries due to Monangai’s recent emergence, Swift continues to produce at a high level.

He’s gone over this line nine times this season, and I expect that trend to continue. The Bears remain committed to running the football, which should give Swift plenty of opportunities to rack up yardage.

Chicago will look to play its brand of football on Sunday night, and that starts with establishing Swift on the ground.

Sign Up at Fanatics and Get $2,000 in FanCash

George Kittle Anytime Touchdown (+100) at Fanatics Sportsbook

There haven’t been many tight ends better than George Kittle over the past few seasons, and I’m backing him to find the end zone as my final prop. Kiittle has 52 receptions for 599 yards and seven touchdowns despite missing time due to injury.

His seven touchdowns rank 12th in the league, highlighting just how dangerous he is in the red zone. Kittle has scored in back-to-back games and has four touchdowns over his last five contests, showing strong chemistry with Purdy.

Outside of McCaffrey, Kittle remains Purdy’s most trusted option, especially near the goal line. Chicago is allowing 217.1 passing yards per game, ranking 18th in the NFL, and that inconsistency creates a prime opportunity for Purdy to connect with Kittle in the end zone on Sunday night.

Join Fanatics Today and Get Up to $2,000 in FanCash