Buffalo Bills Odds

Upstate New York is home to the Buffalo Bills, a team with a consistent record in the NFL since their debut in 1959 and the only team in the league to have visited the Super Bowl in four consecutive years back in the early 90s. Unfortunately, there hasn’t been much to cheer about since, as they lost on all four occasions and are tied with the Minnesota Vikings for having the most Super Bowl appearances without a win.

Despite this, Sean McDermott’s side has had a decent run in the last decade, winning their division every year from 2019 to 2024. Not only do they have an experienced coach at the helm, but they have 2024 season NFL MVP Josh Allen running the charge on the field. Many are expecting the Bills to have a prosperous season with such an instrumental player at their disposal.

In this guide, I will talk to you about everything you need to know about the Bill’s upcoming season, so you can head to your favorite sportsbook and hopefully join the herd of successful bettors.

Buffalo Bills Odds NFL Regular Season 2025/2026

These are the current odds provided by FanDuel for the upcoming season. Want to find out more about one of the nation’s favorite sports betting sites? Read more in our FanDuel Sportsbook review that will give you the rundown before putting your money where your mouth is on any NFL games this season.

Buffalo Bills Odds Regular Season Win Totals

Buffalo Bills Futures Odds

Find more Futures markets to bet on this season, use our predictions, and the latest NFL Futures odds.

Team Odds and Betting Markets

Below are the most popular betting markets that you will find at all good sportsbooks and some example odds for hypothetical scenarios involving the Buffalo Bills.

Team Point Spread

Sometimes football games are only going to go in one direction, and that’s where point spread betting comes into play to make a game a bit more even. Whoever the bookies have as the favorite must win by more than the spread for a wager to come to fruition, and the underdog must lose by less than the spread or win the game outright for the wager to be valid.

Here’s how a team point spread bet would work with a $10 wager and -120 odds on a game between the Bills and Dolphins:

• Spread: Bills -6.5 vs. Dolphins +6.5

• Bills win by more than the spread: You win a profit of $8.33

• Bills win by less than the spread: You lose your money

• Bills lose the game: Your wager is unsuccessful 

Team Over/Under

Over/under betting regards the combined score of the two teams, and if you think it will be over or under this specific number. You are betting on “the line” and the specific number is determined by the sportsbook.

This is what an over/under bet might look like with the Bills facing off against the Chiefs:

$10 wager at -115 odds on Over 48.5 points

• Score is 49 or more: $8.70 made in profit

• Score is 48 or less: You lose your bet

$10 wager at +105 odds on Under 48.5 points

• Score is 48 or less: $10.50 made in profit

• Score is 49 or more: You have lost your bet

Team Moneyline

Moneyline bets are the easiest to understand as you are simply choosing which team you think will win the game. The favorite will always have shorter odds, meaning that your profit lines will be smaller if successful, whereas betting on the underdog and winning your bet will see a lot more money returned to you.

Here’s how a moneyline bet works:

• Bills: -200 (favorite)

• Falcons: +350 (underdog)

If I placed a $10 bet on the Bills to win with -200 odds, I would see a profit of $5 and a total return of $15. Similarly, if I placed the same bet on the Falcons to win, I would win $35 in profit with +350 odds and get a total return of $45.

Team Props

Prop betting relates to individual stats that a team or a player records during a game. You can bet on things like the number of touchdowns, tackles, yards, or more. You will find that odds tend to be a bit more interchangeable on team prop bets as they are a bit more specific than other bets. 

Let’s look at a team prop bet on the number of tackles during a game:

$10 wager on over 8.5 tackles at +130 odds:

• Bills make more than 8.5 tackles in the game: $13 profit made

• Bills make less than 8.5 tackles in the game: Bet lost

$10 wager on under 8.5 tackles at -150 odds:

• Bills make less than 8.5 tackles in the game: $6.67 profit made

• Bills make more than 8.5 tackles in the game: Bet lost

Team Futures

Futures betting is great for those who are able to channel their inner Nostradamus and predict outcomes that come later in the season. This includes things like the number of games won by each team, the season MVP and predictions like if a team will win their division etc. You can win some serious money on team future bets, as odds tend to be a lot higher when you’re betting so far in advance.

For example, if I were to bet $10 on Sean McDermott to win AP NFL Coach Of The Year 2025-26 at +5000 odds and he managed to pull it out of the bag, I would take home $500 in profit and a total return of $510.

Get the most out of betting on football with our comprehensive NFL predictions at WSN.

Team Schedule 

Buffalo Bills Team History

The Buffalo Bills were founded in 1960 as a charter member of the American Football League. The franchise won the AFL Championship in 1964 and 1965 before the AFL merged with the NFL in 1970.

Since then the Bills are the only team to win four consecutive conference championships and also the only team to lose four consecutive Super Bowl games. Otherwise, the Bills have 11 division titles, and 18 playoff appearances to their credit.

From 1990-1993, the Bills made the Super Bowl every single year, remarkably losing each time. In 2007, the Bills snapped an 18-year playoff drought, ending what was the longest active slump at the time. The franchise’s most recognizable players include Jim Kelly, Thurman Thomas, and Bruce Smith. 

Buffalo Bills Player Highlights

Start Betting on the Buffalo Bills

Online sports betting is legal in New York State. You can get started with betting on the Bills with one of the sportsbooks we suggest. See your options below.

For more information and the latest updates, keep an eye on our guide to legal sports betting in New York.