wsn-newsletter

Chiefs vs. Giants Prediction: Expect the Chiefs' Offense to Thrive on Sunday Night

Published: September 19, 2025, 10:00 AM ET
6 min read
  • Patrick Mahomes has lost three games in a row for the first time in his NFL career

  • Cam Skattebo led the New York Giants backfield with 11 rush attempts in week two

  • The Giants' defensive line ranks below league average in Def Pass Rush Win Rate

Patrick Mahomes heads into Sunday night in uncharted territory as he has now lost his last three games in a row for the first time in his career. Fortunately for the former NFL MVP, positive regression looms large as he faces off against the New York Giants who struggle to generate pressure. This will result in a cleaner pocket for Mahomes, increasing his chances of driving down the field.

For more NFL Week 3 insights, take a look at our NFL offense rankings, along with our NFL defense rankings.

Chiefs vs. Giants Odds

Odds provided by BetMGM Sportsbook. Get up to $1,500 back in the form of bonus bets* should you lose your first wager after creating an account with the WSN promo code WSNSPORTS.

TeamsMoneylineSpreadTotal
Kansas City Chiefs-295-6.5 (-110)45.5 (-110)
New York Giants+240+6.5 (-110)45.5 (-110)

*21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements.

Best NFL Sportsbooks
How We Rate
Affiliate Disclaimer
21+
Biggest Payouts
Sleeper # 1
Sleeper star 4.2/5
Sleeper Review
$100 Deposit Match
Claim Now
21+ Terms and Conditions Apply.
Betr # 2
Betr star 3.8/5
Betr Review
$200 Deposit Match + $10 on Signup
Claim Now
21+ T&Cs Apply
FanDuel # 3
FanDuel star 4.5/5
FanDuel Review
100% Deposit Match up to $100
Claim Now
21+ | Min Deposit $10. T&Cs apply
OwnersBox # 4
OwnersBox star 4.5/5
OwnersBox Review
$100 Deposit Match Bonus
Claim Now
Wanna Parlay # 5
Wanna Parlay star 4.1/5
Wanna Parlay Review
Deposit Match up to $250
Claim Now
Underdog # 6
Underdog star 4/5
Underdog Review
Play $5, Get $50
Claim Now
18+ Terms and Conditions Apply
Playsqor # 7
Playsqor star 4/5
Playsqor Review
Up to $500 Bonus Funds
Claim Now
Chalkboard # 8
Chalkboard star 4.3/5
Chalkboard Review
$20 No Deposit Bonus
Claim Now
No Purchase Necessary. Void where prohibited. All bonus funds returned from free entries require a 1x play-through before withdrawal. Other restrictions apply. Must be 18+ to enter (19+NE, 21+ MA) and present in a state where Chalkboard operates. Concerned with your play? Call 1-800-GAMBLER or visit www.nop.ambling.org
Chiefs vs Giants 2025 09 21 Patrick Mahomes

Chiefs vs. Giants My Pick

Do not let the Kansas City Chiefs' 0-2 start fool you, they are still one of the top contenders to win the Super Bowl as they have been competitive in their losses. Patrick Mahomes has managed to play at a high level as the Chiefs' star quarterback heads into week three ranked above league average in Quarterback EPA per play and in PFF Grade.

In Sunday’s contest against the New York Giants, Mahomes will have a great opportunity to build on his momentum as he faces off against a defense who ranks near dead last in Def EPA. Especially when he will have more time in the pocket to operate and let his plays develop as the Giants' defensive line currently resides near the bottom of the board in Def Pass Rush Win Rate.

On the other side of the field, the Giants' offensive line have struggled to hold their ground as they rank below league average in Pass Protection and in Run Block. This will allow the Chiefs to generate pressure at a consistent rate which will lessen the quality of Russell Wilson’s throws. With Wilson expected to struggle, the Giants will be prone to early outs which will lead to an uptick in the number of offensive possessions for the Chiefs.

Use WSNSPORTS at BetMGM for $1,500 Bonus

Chiefs vs. Giants Prediction

Kansas City Chiefs Preview

With the Giants' front seven struggling to stop the run as their below league average mark in Run Defense Win Rate indicates, the Chiefs' ground game are also in a position to round back into form after a slow start to the year. Isaiah Pacheco has yet to find his footing this season as the Chiefs' running back ranks near the bottom of the board in Rushing Yards Over Expected per carry.

With the Chiefs' ground game expected to play at a competitive level, this will open up the field for the Chiefs' pass catchers as the Giants will be forced to crash down their linebackers to help plug the gaps in the trenches. This will lead to higher quality passing lanes for Mahomes to exploit which will increase his chances of moving the ball down the field through the air.

Claim $1,500 in Bonus Bets at BetMGM

New York Giants Preview

While Russell Wilson did look like his former Super Bowl-winning self in week two’s matchup against Dallas, it’s worth noting the quality of defense that he faced as the Cowboys rank 29th overall in Def EPA. Wilson still struggles to move the needle with just his individual production as he sits in the bottom half of the board in Quarterback Efficiency and in EPA per play.

As for the Giants' ground game, Cam Skattebo has potentially dethroned Tyrone Tracy Jr. for the starting role in week two as he unexpectedly led the team in rush attempts while averaging over four yards per carry. Should Skattebo help elevate the Giants' offense as a whole, then that will help lessen the amount of variance in their contests which increases their chances of winning.

Claim $1,500 Bonus Offer at BetMGM

Chiefs vs. Giants Injuries

Kansas City Chiefs

  • Rashee Rice - Suspended

  • Xavier Worthy - Questionable

  • Mike Danna - Questionable

New York Giants

  • Andrew Thomas - Questionable

  • Rakeem Nunez-Roches - Questionable

  • Darius Muasau - Questionable

Chiefs vs. Giants: Best Promos and Sportsbooks

If you currently do not have an account with BetMGM Sportsbook, you can get up to $1,500 back in the form of bonus bets* should you lose your first wager with the WSN promo code WSNSPORTS. BetMGM also rolls out various promotions throughout the season which gives their users more ways to earn bonus bets and parlay boosts to help increase their bankroll.

Find more NFL betting promos in the table below. Also, check our curated selection of the best NFL betting sites.

SportsbookPromoPromo CodeSign Up Link
bet365 SportsbookBet $5, Get $200 in Bonus Bets Win or LoseWSN365Sign Up Here
BetMGM SportsbookBet $10, Get $150 if You Win*WSNSPORTSSign Up Here
BetRivers Sportsbook$500 Bonus BetNo code neededSign Up Here
Caesars SportsbookBet $1, Double Your Winnings Next 20 BetsWSN20XSign Up Here
Crab SportsGet up to $500 if Your First Bet WinsWSNCRABSign Up Here
FanDuel SportsbookBet $5, Get $300 in Bonus Bets if Your Bet WinsNo code neededSign Up Here
Hard Rock BetBet $5, Get $150 in Bonus Bets if You WinNo code neededSign Up Here

*21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

How to Watch Chiefs vs. Giants

  • When: September 21, 8:20 pm EST

  • Where: MetLife Stadium, East Rutherford, New Jersey

  • How to Watch: NBC

More NFL Week 3 Stories

NFL Week 3 Odds

Chiefs vs. Giants Prop Bets SNF Week 3

Chiefs vs. Giants Same Game Parlay SNF Week 3

NFL Week 3 Picks Against the Spread

tip_r

Responsible Gambling

If you or someone you know needs support or wants to speak with a professional about responsible gambling, seek out the correct resources. Call or text 1-800-GAMBLER (US), 877-8-HOPENY (NY), 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR) to get help. Visit 1800gambler.net for more information.

WSN is an advocate for safe gambling practices. Visit our Responsible Gambling Center for more details.

Kody Malstrom WSN Contributor

Kody Malstrom

Sports Betting Analyst

Expertise:
MLB
NHL
Betting Picks
Kody Malstrom is a sports betting journalist with six years of writing experience in the industry. He covers an abundance of sports, including College Football, NFL, College Basketball, NBA, and more. Born and raised in Michigan, Kody is a devoted Detroit Sports fan and spends his Sundays rooting for the Detroit Lions while telling himself this year is the year they win it all. When not staring at betting markets, Kody spends his free time at the beach in the summer or snowboarding in the winter.
Email: [email protected]
Nationality: American
Education: Bachelor of Finance
Favourite Sportsbook: Caesars Sportsbook
Favourite Casino: BetMGM Casino
Experience: 6 years

We've been featured on:

espn logo reuters logo cbs-news logo forbes logo entrepreneur logo la times logo
We only list licensed sportsbooks