NFL Week 18 Odds: Odds and Betting Lines for Every Game

• The Seahawks and 49ers will compete for the top NFC seed on Saturday

• The Jaguars can win the AFC South with a win on Sunday

• The Broncos can earn the top seed in the AFC with a win on Sunday

Division championships and playoff seeds are on the line this weekend. We have two NFL games on Saturday and 14 more contests on Sunday. 

The most noteworthy story heading into Week 18 is the competition for the top seeds in the AFC and NFC. The NFC’s top seed will be decided on Saturday when the Seahawks face the 49ers. 

The Broncos can clinch the AFC with a victory over the Chargers on Sunday. Here, we will discuss the betting lines and odds for these games as well as the rest of the Week 18 slate. 

For more info on the league standings, check our latest NFC Championship odds, along with the AFC Championship odds.

NFL Odds for Week 18

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Panthers vs. Buccaneers Odds, Saturday, 4:30 PM EST

• Panthers: Spread +2.5 (-105) | Moneyline +125

• Buccaneers: Spread -2.5 (-115) | Moneyline -150

• Total: Over/Under 44.0 (-110/-110)

The Panthers are in a prime position to win the NFC South. If Carolina beats Tampa Bay or the Falcons beat the Saints on Sunday, the Panthers will earn the division title. 

The Buccaneers are 1-7 over their past eight games and have one of the worst defenses in the NFL during this stretch. Tampa Bay is playing like the season is over, and they are still the favorites. 

Bryce Young and company are hungry for a win, and this is where they surpass the Buccaneers in a division Tampa Bay has owned for half of a decade. 

Seahawks vs. 49ers Odds, Saturday, 8:00 PM EST

• Seahawks: Spread -1.5 (-105) | Moneyline -120

• 49ers: Spread +1.5 (-115) | Moneyline +100

• Total: Over/Under 49.5 (-110/-110)

The Seahawks have a defense capable of winning the Super Bowl. The 49ers’ defense can’t stop a nosebleed. 

On the flip side, San Francisco has a high-powered offense, whereas Seattle has an inconsistent scoring unit. Defense is usually more consistent than offense, and Seattle is healthier. If Sam Darnold holds onto the ball, his team has a great chance to prevail. 

Find the latest Super Bowl odds and predictions here.

Saints vs. Falcons Odds, Sunday, 1:00 PM EST

• Saints: Spread +3.0 (-115) | Moneyline +135

• Falcons: Spread -3.0 (-105) | Moneyline -160

• Total: Over/Under 43.5 (-110/-110)

After a rough start to the season, Tyler Shough has become one of the best young quarterbacks in the NFL. Shough has thrown for 2,125 yards and nine touchdowns this season. 

He has also been dominant on the ground, so the Saints are in a strong position to win this game. The Falcons are coming off a win over the Rams, but I fear that they have no gas left in the tank. 

Browns vs. Bengals Odds, Sunday, 1:00 PM EST

• Browns: Spread +7.5 (-110) | Moneyline +275

• Bengals: Spread -7.5 (-110) | Moneyline -350

• Total: Over/Under 44.5 (-110/-110)

Joe Burrow and the Bengals dominated the Cardinals last week. Shedeur Sanders and the Browns are also coming off a huge win as they beat the AFC North-leading Pittsburgh Steelers. Get the latest AFC North odds here.

Cleveland has one of the best defenses in the NFL, but they have to face elite weapons for Cincinnati. Over 60 minutes, the Bengals’ offense will make more plays than the Browns', resulting in a Cincinnati win. 

Packers vs. Vikings Odds, Sunday, 1:00 PM EST

• Packers: Spread +6.5 (-110) | Moneyline +235

• Vikings: Spread -6.5 (-110) | Moneyline -290

• Total: Over/Under 36.5 (-110/-110)

Malik Willis has done an excellent job filling the void for Jordan Love during his injury. Willis is 0-2 in his past two appearances, but he has been more explosive than Love at quarterback. 

The Packers are in the playoffs and will likely sit starters in this contest. Meanwhile, this is the Vikings' final game of the season, and we should see a full effort. 

Cowboys vs. Giants Odds, Sunday, 1:00 PM EST

• Cowboys: Spread -4.0 (-110) | Moneyline -220

• Giants: Spread +4.0 (-110) | Moneyline +180

• Total: Over/Under 51.5 (-110/-110)

The Dallas Cowboys had one of the most explosive offenses in the NFL this season. Dak Prescott has targeted CeeDee Lamb and George Pickens all season, and it has led to many points.

Dallas didn’t make the playoffs, but it would be surprising to see them drop this game against the Giants. If the Cowboys eliminate Jaxson Dart’s ability to run the ball, New York shouldn’t be competitive. 

Titans vs. Jaguars Odds, Sunday, 1:00 PM EST

• Titans: Spread +12.5 (-110) | Moneyline +500

• Jaguars: Spread -12.5 (-110) | Moneyline -700

• Total: Over/Under 47.5 (-110/-110)

The Jacksonville Jaguars survived against the Colts last week, setting themselves up with a chance to win the AFC South on Sunday. The Jaguars have embraced the underdog role even though they’re playing like one of the best teams in the NFL. 

The Titans have a young team and should be better next season. However, Cam Ward isn’t outplaying Trevor Lawrence on Sunday. 

Colts vs. Texans Odds, Sunday, 1:00 PM EST

• Packers: Spread +10.0 (-110) | Moneyline +400

• Vikings: Spread -10.0 (-110) | Moneyline -550

• Total: Over/Under 39.5 (-110/-110)

The Houston Texans are a double-digit favorite over the Indianapolis Colts on Sunday. The Colts have been eliminated from the playoffs despite some fantastic play from Philip Rivers. 

The Texans' defense is elite and will swarm the Colts throughout this contest. Additionally, Indianapolis has been very shaky on defense, which should open up CJ Stroud for a solid outing. 

Jets vs. Bills Odds, Sunday, 4:25 PM EST

• Jets: Spread +7.0 (-110) | Moneyline +280

• Bills: Spread -7.0 (-110) | Moneyline -360

• Total: Over/Under 38.0 (-110/-110)

Josh Allen will most likely not play for the Bills on Sunday, and Buffalo is still a seven-point favorite. The Jets had no chance against the Patriots' backups in the second half last week, and it will be the same against Buffalo. 

Brady Cook hasn’t been efficient, and the Jets’ rushing attack has been lackluster behind Breece Hall. The Bills should gain significant momentum heading into the playoffs from this game. 

Lions vs. Bears Odds, Sunday, 4:25 PM EST

• Lions: Spread +2.5 (-110) | Moneyline +125

• Bears: Spread -2.5 (-110) | Moneyline -150

• Total: Over/Under 50.5 (-110/-110)

The Detroit Lions had a down season and will miss the playoffs in 2025. However, they are the favorites this week against Chicago on the road. Dan Campbell should use this game to build momentum heading into 2026, while the Bears will rest starters. 

As long as Jared Goff controls the ball, this contest should go in favor of Detroit. The Lions’ starters will be better than the Bears’ backups. 

Chargers vs. Broncos Odds, Sunday, 4:25 PM EST

• Chargers: Spread +12.5 (-110) | Moneyline +550

• Broncos: Spread -12.5 (-110) | Moneyline -800

• Total: Over/Under 37.5 (-110/-110)

One of the bigger stakes games of the week will occur in Denver on Sunday. The Broncos have a chance to earn the top seed in the AFC with a win over the Chargers. 

Los Angeles would have been fighting for the AFC West with a victory over the Texans last week. However, this won’t be the case due to their loss. Therefore, the Chargers are more motivated, and it should result in a victory. 

Chiefs vs. Raiders Odds, Sunday, 4:25 PM EST

• Packers: Spread -5.5 (-110) | Moneyline -270

• Vikings: Spread +5.5 (-110) | Moneyline +220

• Total: Over/Under 36.5 (-110/-110)

The Chiefs and Raiders are both playing for nothing at this point in the season. The Raiders are in line to get the number one pick with a loss, and they’re resting starters to make sure this happens. 

While the Chiefs don’t have Patrick Mahomes, they still nearly beat the Broncos last week with their third-string quarterback. I don’t expect the Raiders to provide too much resistance. 

Cardinals vs. Rams Odds, Sunday, 4:25 PM EST

• Cardinals: Spread +7.5 (-115) | Moneyline +300

• Rams: Spread -7.5 (-105) | Moneyline -380

• Total: Over/Under 46.5 (-110/-110)

The Los Angeles Rams are competing for the No. 5 seed in the NFC. This is a coveted spot because it will face the Buccaneers or Panthers, rather than the Bears or Eagles. 

The Rams lost to the Falcons last week, so they need to win and have the Seahawks prevail on Saturday to secure the No. 5 seed. 

The Cardinals have been one of the worst teams in the NFL, and I don’t see this changing. 

Dolphins vs. Patriots Odds, Sunday, 4:25 PM EST

• Dolphins: Spread +11.5 (-110) | Moneyline +450

• Patriots: Spread -11.5 (-110) | Moneyline -600

• Total: Over/Under 45.5 (-110/-110)

The Patriots clinched the AFC East, but there is still an outside chance of them winning the one seed if the Broncos lose on Sunday. It’s highly doubtful this happens, but Mike Vrabel is expected to have starters on the field for a portion of this game. 

Miami is coming off a win against Tampa Bay, but they’re not very good, and they really struggle in the cold. 

Commanders vs. Eagles Odds, Sunday, 4:25 PM EST

• Commanders: Spread +7.0 (-110) | Moneyline +270

• Eagles: Spread -7.0 (-110) | Moneyline -340

• Total: Over/Under 41.0 (-110/-110)

The Eagles are playing for seeding on Sunday, but shouldn’t have their starters on the field for too long in this game. The Commanders have been one of the worst teams in the NFL, and they’re outmatched in this contest. 

Philadelphia’s defense is dominant, and this should show throughout this contest. It will be surprising to see Washington generate many points with Josh Johnson at quarterback. 

Ravens vs. Steelers Odds, Sunday, 8:20 PM EST

• Ravens: Spread -3.5 (-105) | Moneyline -190

• Steelers: Spread +3.5 (-115) | Moneyline +160

• Total: Over/Under 41.0 (-110/-110)

The AFC North is on the line on Sunday when the Ravens face the Steelers. The Steelers losing to the Browns in Week 17 set up this title game, and I’m leaning toward Baltimore. 

Pittsburgh doesn’t have DK Metcalf, which will make their offensive game plan difficult.  Derrick Henry had four touchdowns last week, so expect Baltimore to pound the rock and pick up a difficult win. 

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