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NFL Odds Week 7: Odds and Betting Lines for Every Game

Updated: October 16, 2025, 11:45 AM ET
10 min read
  • The Buccaneers will face the Lions on Monday night 

  • Baker Mayfield is picked second to win MVP

  • The Bills and Ravens are on bye weeks 

Week 7 has multiple marquee matchups with playoff implications. Mike Vrabel will return to Tennessee for the first time after being fired, and the Buccaneers will face the Lions on Sunday Night Football. 

Numerous Super Bowl contenders are in action this week. Here, we will give a short analysis of each game on the board with our pick. 

NFL Odds for Week 7

Odds courtesy of bet365 sportsbook. bet365 is one of our favorite NFL betting sites. If you bet $5, you get $200 in bonus bets by using our promo code WSN365 at registration.

MatchupSpreadTotalMoneyline
Steelers
vs
Bengals
-5.5 (-110)O 44.5 (-110)-260
+5.5 (-110)U 44.5 (-110)+210
Rams
vs
Jaguars
-3.0 (-110)O 44.5 (-110)-165
+3.0 (-110)U 44.5 (-110)+140
Saints
vs
Bears
+5.0 (-110)O 47.0 (-110)+200
-5.0 (-110)U 47.0 (-110)-245
Dolphins
vs
Browns
+2.5 (-110)O 39.5 (-110)+125
-2.5 (-110)U 39.5 (-110)-150
Patriots
vs
Titans
-7.0 (-110)O 42.0 (-110)-340
+7.0 (-110)U 42.0 (-110)+270
Raiders
vs
Chiefs
+12.0 (-110)O 45.5 (-110)+525
-12.0 (-110)U 45.5 (-110)-750
Eagles
vs
Vikings
-1.5 (-110)O 44.0 (-110)-125
+1.5 (-110)U 44.0 (-110)+105
Panthers
vs
Jets
-1.5 (-110)O 42.0 (-110)-120
+1.5 (-110)U 42.0 (-110)+100
Giants
vs
Broncos
+7.0 (-110O 40.0 (-110)+280
-7.0 (-110)U 40.0 (-110)-360
Colts
vs
Chargers
+1.5 (-110)O 48.5 (-110)+110
-1.5 (-110)U 48.5 (-110)-130
Commanders
vs
Cowboys
-1.5 (-110)O 54.5 (-110)-130
+1.5 (-110)U 54.5 (-110)+110
Packers
vs
Cardinals
-6.5 (-110)O 45.0 (-110)-315
+6.5 (-110)U 45.0 (-110)+255
Falcons
vs
49ers
+2.0 (-110)O 47.0 (-110)+115
-2.0 (-110)U 47.0 (-110)-135
Buccaneers
vs
Lions
+5.5 (-110)O 52.5 (-110)+210
-5.5 (-110)U 52.5 (-110)-260
Texans
vs
Seahawks
+3.0 (-110)O 41.0 (-110)+145
-3.0 (-110)U 41.0 (-110)-170

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NFL Odds Week 7

Steelers vs. Bengals Odds, Thursday, 8:15 PM EST

The AFC North kicks off the Week 7 slate when the Steelers travel to Cincinnati to face the Bengals. The Bengals are close to a touchdown underdog at home, and this is warranted. 

Joe Flacco made his debut for the Bengals on Sunday against the Packers. He was 29-45 for 219 yards and two touchdowns. 

The Bengals are better equipped to win with Flacco, and he should be more prepared in his second start. Cincinnati has a great chance to cover the spread to start the Week 7 slate. 

Rams vs. Jaguars Odds, Sunday, 9:30 AM EST

The NFL will play in London for the third consecutive week when the Rams face the Jaguars. Los Angeles could be without Puka Nacua, and this would be a significant loss. 

Nacua injured his ankle on Sunday, but the Rams still beat the Ravens 17-3. Nacua is first in receptions and yards, so look for Los Angeles to run the ball against Jacksonville. 

The Rams are still favored without their best player, and they should leave London victorious.

Saints vs. Bears Odds, Sunday, 1:00 PM EST

Spencer Rattler is starting to look like an NFL quarterback for the New Orleans Saints. The Saints lost to the Patriots, but Rattler was 20-26 for 227 yards, and he was getting the ball out of his hands quickly.

Rattler must be great once again, and they have a legitimate chance to win on Sunday. Yet, Chicago is also improving rapidly, and their quarterback is getting better. 

The Bears also had extra time to prepare with their Week 6 bye, and this should show throughout the contest. 

Dolphins vs. Browns Odds, Sunday, 1:00 PM EST

Tua Tagovailoa was discussing how players don’t show up to team meetings after the Dolphins' loss on Sunday. It seems like everything has fallen apart for Miami, and they don’t match up well against the Browns. 

Cleveland's offense is improving, and they have one of the best defenses in the NFL. The Dolphins should struggle to run the ball in this contest, giving Cleveland the edge. 

Patriots vs. Titans Odds, Sunday, 1:00 PM EST

The New England Patriots are coming off a win over the New Orleans Saints. Drake Maye is playing at an MVP level, and this isn’t something many people would have guessed after Week 1. 

The Titans just fired their head coach, Brian Callahan. Teams always seem to play harder the week after firing a coach, but Mike Vrabel will have the Patriots amped up for this game.

Tennessee fired Vrabel in his last head coaching role, and his team will be looking to get some revenge for their leader. 

Raiders vs. Chiefs Odds, Sunday, 1:00 PM EST

The Kansas City Chiefs are looking like a legitimate Super Bowl contender. They beat the Lions on Monday and will face the Raiders in an AFC West battle in Week 7.

Patrick Mahomes was fantastic against the Lions, throwing for 257 yards and three touchdowns in the win. Las Vegas won its second game of the season on Sunday, but they have a challenging task against Kansas City.

The Chiefs own the Raiders, and are starting to mesh on both sides of the ball, but the spread is too big in a division game. 

Eagles vs. Vikings Odds, Sunday, 1:00 PM EST

The Eagles were dominated by the Giants on Thursday Night Football one week ago. The team didn’t play well on either side of the ball, and their effort level was embarrassing. 

Philadelphia is a short road favorite against the Vikings, who have one of the best defenses in the NFL. It’s hard to trust the Eagles because their energy on both sides of the ball is bad, and they seem to have many locker room distractions. 

Minnesota is a much more connected team, and this should show on Sunday. 

Panthers vs. Jets Odds, Sunday, 1:00 PM EST

The New York Jets are the worst football team in the NFL. They have lost six games and have no vertical passing attack.

Justin Fields does not look like an NFL quarterback. He has thrown for 799 yards and four touchdowns in five starts. 

The Panthers are coming off a win over the Cowboys, and Bryce Young has been relatively clutch despite some shaky performances over his brief career. 

Giants vs. Broncos Odds, Sunday, 4:05 PM EST

The New York Giants have been energized by their rookie quarterback, Jaxson Dart. Dart has been outstanding in three starts. 

Dart has thrown for 508 yards and four touchdowns this season. He is playing better than you could expect of any rookie, but the Broncos' defense will be his biggest test of the year. 

Denver’s defense has a ruthless pass rush, which should give Dart trouble on Sunday. Bo Nix needs to play better, but Denver is the superior team. 

Colts vs. Chargers Odds, Sunday, 4:05 PM EST

Daniel Jones has been one of the biggest success stories of the season. He has led the Colts to a 5-1 record and looked excellent in the process. 

The quarterback has thrown for 1,502 yards on the season with eight touchdowns, and he has the best QBR in the NFL. 

The Chargers have a well-rounded team, but they have plenty of inefficiencies. Indianapolis has the better team, and they’re a plus-money dog on the road. 

Commanders vs. Cowboys Odds, Sunday, 4:05 PM EST

Dak Prescott has played like an NFL MVP this season, but he has one of the worst defenses in the NFL. The Cowboys lost to the Panthers, despite the offense putting up big numbers. 

Dallas’ defensive coordinator, Matt Eberflus, has no answers for their opponents. The Commanders have some injuries, but Jayden Daniels is one of the best young quarterbacks in the game. 

This should be a high-scoring contest, but Washington’s defense has the edge. 

Packers vs. Cardinals Odds, Sunday, 4:25 PM EST

The Green Bay Packers are favored to win the NFC Championship. This is warranted as they’re the most talented team in the conference. 

Josh Jacobs is a physical running back, and he will put Arizona’s defensive line to the test. The Cardinals' defense has been one of the bright spots of the group, but the Packers are too strong in the trenches to not control this contest. 

Falcons vs. 49ers Odds, Sunday, 8:20 PM EST

The Atlanta Falcons are always a tough test for any opponent because they have a formidable team. Bijan Robinson has been outstanding this season and had an 81-yard touchdown run against the Bills in Week 6. 

The 49ers are riddled with injuries, giving Atlanta a great chance to win. Fred Warner is now done for the season, and San Francisco’s defense will struggle without him against Atlanta’s multiple weapons.

Buccaneers vs. Lions Odds, Monday, 7:00 PM EST

Brian Branch won’t play for the Lions on Monday after his fight with JuJu Smith-Schuster last week. The Lions were beat up on defense by the Chiefs, and the Buccaneers have the same capability. 

Detroit is a short favorite at home, but the Buccaneers are a better team. The biggest concern for Tampa Bay heading into this game is their health. 

Tampa Bay has numerous receiver injuries, and eventually Baker Mayfield can’t save the team. 

Texans vs. Seahawks Odds, Monday, 8:20 PM EST

The Houston Texans' offense has been horrendous in 2025. They will have a challenge keeping pace with the Seattle Seahawks, who have scored at will with Sam Darnold. 

Jaxon Smith-Njigba has become one of the best wide receivers in the NFL, and he should post massive numbers this week against Houston. 

The Texans' defense can only keep them in this game for so long.

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Tanner Kern

Tanner Kern

Sports Betting Analyst & On-Air Host

Expertise:
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Tanner Kern has been working in the betting industry since 2020. He currently is a social media content creator at DraftKings and contributes to multiple sites in addition to WSN, including Forbes and VSiN. He is also the cohost of the podcast Ride the Line at WSN.
Email: [email protected]
Nationality: American
Education: M.S in Sports Journalism
Favourite Sportsbook: Fanatics Sportsbook
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Experience: 4 years
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