When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

St. Louis Cardinals vs New York Mets Predictions, Odds, Picks

Written by: Tony Garcia
Updated October 14, 2022
12 min read
  • Can Cardinals take advantage of pitching edge
  • Mets look to get offenes going again
  • X-factors to watch

Cardinals vs Mets Odds

Odds taken from DraftKings.

Team Run Spread Money Line Total
St. Louis Cardinals +1.5 (-195) EVEN O 8.5 (EVEN)
New York Mets -1.5 (+165) -120 U 8.5 (-120)

Cardinals vs Mets Prediction and Picks

St. Louis hopes to continue its momentum after soundly beating the Giants Sunday night. The Mets, meanwhile, haven’t been stringing wins together in their own right – they haven’t won more than two games in a row since April 27th. But this one comes down to pitching. Miles Mikolas is too good to bet against right now!

Cardinals (EVEN)

Garcia’s 2021 record: (13-8)

Check ot the list of MLB promo codes and betting bonuses here!

Play Fantasy Sports Here!

🔥 Claimed by 131 people this week!



Get a No Sweat First Bet up to $1,500

21+ | T&Cs apply

Cardinals Vs Mets 2022 05 16

Cardinals vs Mets Betting Trends to Watch

  • Cardinals are 13-5 in their last 18 during game 1 of a series
  • Cardinals are 20-8 in their last 28 road games
  • Cardinals are 16-7 in their last 23 vs. a team with a winning record
  • Cardinals are 3-5 in their last 7 overall
  • Under is 5-1 in Cardinals last 6 Monday games
  • Under is 5-2 in Cardinals last 7 games as a road underdog
  • Cardinals are 11-5 in the last 16 head-to-head meetings
  • Cardinals are 4-0 in the last 4 meetings in New York
  • Mets are 9-2 in their last 11 home games vs. a right-handed starter
  • Mets are 7-2 in their last 9 during game 1 of a series
  • Mets are 7-2 in their last 9 vs. a team with a winning record
  • Mets are 23-11 in their last 34 games as a favorite
  • Over is 4-1 in Mets last 5 games as a home favorite
  • Under is 5-2 in Mets last 7 games as a favorite

Cardinals Hold Advantage on the Mound

The Mets have been one of the best teams in baseball in 2022. The Cardinals, certainly by their standard, have struggled. But if you’re looking for one area where St. Louis can impose its will, it’s in this pitching matchup.

St. Louis’ starter Miles Mokalis has looked like an All-Star this year, and he enters the game after six straight stellar starts. The 33-year-old is 3-1, and ranks third in the MLB in the ERA (1.49), 11th in the league in WHIP (0.94) and has 31 strikeouts in 42.1 innings.

Mikolas has gone seven innings or more in three of the past four games, has given up two runs or fewer in six straight appearances and has only allowed more than four hits in one of those games.

For the Mets, Trevor Williams has been sub-par this year, but frankly, he’s never been all that reliable in his career. Williams is making just the second start of the year – he’s appeared in four games out of the bullpen – and thus far he’s 0-2 with a 5.73 ERA, 1.64 WHIP and nine strikeouts in 11 innings.

That said, his last time out he was good. Williams threw 3.2 innings, giving up just two hits against the Nationals. He will look to build on that.

Mets Try to Get Back to Form

The Mets are  in first place in the NL East. They have lost consecutive games just once this season and that was back on April 10-11. They’ve been one of the better stories this year, but over the past nearly three weeks they’ve come back to earth.

New York is just 9-8 in its past 17 games and have been outscored by three runs in that stretch (they had outscored their opponents by 38 runs in the first 18 games this season).

Part of the reason for their “struggles”, is four of the team’s best hitters have gone cold over the past week. Francisco Lindor (5-for-26), Jeff McNeil (4-for-24) Mark Canha (3-for-18) and Eduardo Escobar (1-for-24) are a combined 13-for-92 with one home run and two doubles in the past seven days.

St. Louis, meanwhile (prior to Sunday night’s offensive explosion) hadn’t scored all that consistently this season, ranking in the middle of the league (15th) in runs scored.

That said, the Cardinals still have two of the most dominant offensive threats in the game in Paul Goldschmidt and Nolan Arenado. Goldschmidtt had three hits Sunday with a home run and a double and now is hitting .312 with a .394 OPS.

Arenado is top 15 in the league in most major stats too, batting .312 (T-15), seven home runs (T-15th), 27 RBIs (T-4th) and .952 OPS (8th).

X-factors to Watch

For New York, we’re going to single out red-hot outfielder Brandon Nimmo. Nimmo went 11-for-24 last week with five walks – a .567 OBP. He’s also been solid against righties all year, batting .291 with a .398 OPS.

On the other side, it’s important to pick someone who excels on the road and that’s Tommy Edman. Edman is hitting .271 away from home with a .368 OPS. and is second on the team in home runs away from home (2) and RBIs (10).

Play Fantasy Sports Here!

Logo #1



Bet $5, Get $150 in Bonus Bets

21+ | Terms and conditions apply

Logo #2



$500 Bonus Bet

21+ | VA only | Gambling problem? Call 1-800-532-3500

How to Watch Cardinals vs Mets

St. Louis Cardinals vs New York Mets Information
Teams St. Louis Cardinals vs New York Mets
Location Citi Field, Queens, New York
Time Monday, May 16, 7:10  p.m. EST
How to watch Bally Sports MidWest, SportsNet New York
Image for Tony Garcia


Tony Garcia

180 Articles

Tony writes about baseball for WSN.com after recently graduating with his Masters from the Medill School of Journalism at Northwestern University. Prior to that, Tony was a local sports reporter for MLive Media Group, based out of Jackson, Michigan where he covered everything from high school to professional sports. He graduated from Michigan State in 2015 with a degree in journalism. During his time there he covered the Michigan State football and men’s basketball teams from 2013-15 and hosted a sports radio show on WDBM 89FM.

More info on Tony Garcia
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks

© Rebel Penguin ApS 2024 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.