Los Angeles FC vs. Inter Miami CF Prediction: MLS Showpiece Matchup Kicks off Season Opener

• Los Angeles FC were knocked out in the 2025 Western Conference semifinal 

• Inter Miami CF claimed its first league title last year, getting the better of the Vancouver Whitecaps

Saturday, the 2026 MLS campaign kicks off with a matchup between two sides who are considered threats to raise the league crown in December. Los Angeles FC will welcome Inter Miami CF to the historic Los Angeles Memorial Coliseum for the heavyweight spectacle. 

Here, we will break down the betting odds and share our favourite picks for Los Angeles FC vs. Inter Miami CF.

Los Angeles FC vs. Inter Miami CF Betting Odds for Saturday, February 21

The books have designated the home side as the likeliest to come away with all three points, as shown in the displayed odds. LAFC are priced at +110 to win while Inter Miami are +210. If both teams are level after 90, the draw is penned in at +260.

Los Angeles FC vs. Inter Miami CF Odds

The following odds are taken from bet365 sportsbook. Use our promo code WSN365 at bet365 to claim your bonus: Bet $5, Get $150 in Bonus Bets Win or Lose.

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Los Angeles FC vs. Inter Miami CF Betting Prediction

Los Angeles FC Preview

Marc Dos Santos is the new voice in charge on the touch line, as he took over Steven Cherundolo’s spot, who stepped down at the end of last year. The Canadian coach won’t have much of an adjustment period getting to know his players, he has served as one of LAFC’s assistant coaches since 2022. The previous term, the Black and Gold finished third overall in the Western Conference. With the personnel the team possesses, there is no reason why they can’t replicate what they did in 2025. 

LAFC will now have a full year of Son Heung-min on the pitch, which could have negative consequences for the opposition. The captain of the South Korea national team shredded it up with his MLS debut season, amassing 12 goals and three helpers between regular and postseason play. Paired up with Denis Bouanga, who racked up 24 goals in 2025, the duo will be a load to handle this weekend and in the future.

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Inter Miami CF Preview

Messi and Co. arrive at the season opener as defending champions, as the Herons added their first MLS Cup to their trophy cabinet last year. Once again, Javier Mascherano and his colleagues are selected as the favourites before matchday one to repeat as league title holders. During the 2025 regular season, Inter Miami CF finished one point shy of winning the Supporters’ Shield, an award handed out to the club with the most points acquired during the 34 game tournament.

All of Inter Miami’s success will hinge on one of the best to do its craft on the pitch, Lionel Messi. The 38-year-old had his way facing the opposing keepers last season, cataloging 43 goals in 49 appearances across all competitions played, and for good measure, he helped set up his teammates with 25 tallies. Bolstering the attack on an already high-flying club, the Herons brought over German Berterame for an MLS hefty fee. The Mexican forward has been with C.F. Monterrey in Liga MX since 2022, scoring 68 goals in all competitive matches.

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Los Angeles FC vs. Inter Miami CF - My Pick

• Los Angeles FC vs. Inter Miami CF pick: Los Angeles FC moneyline three-way (+110) at bet365

The reigning league champions arguably retain one of the best squads in MLS, but so does LAFC. Suffering a knock in a preseason match, Lionel Messi's status to play on Saturday could be a game-time decision. Even if the Argentine legend is fit enough to get some minutes, it might not be enough to help the team get the better of LAFC. We feel the home side wants to send a message that they can hang with the league's jewel.

On Los Angeles soil last year, the Black and Gold proved to be a strong out, claiming 11 wins out of 17 home dates. With Inter Miami having surrendered uncharacteristic goals during preseason, we fancy the hosts to take advantage of the Herons defensive mishaps.

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How to Watch Los Angeles FC vs. Inter Miami CF

• When: February 21, 9.30 p.m. ET

• Where: Los Angeles Memorial Coliseum

• TV: Apple TV