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Cardinals vs. Seahawks Prop Bets TNF Week 4: Monitor the Cardinals Injury Report

Published: September 24, 2025, 09:30 AM ET
4 min read
  • The Seattle Seahawks' Sam Darnold leads the league in Quarterback PFF Grade

  • The Arizona Cardinals currently have five cornerbacks listed on their injury report

  • Arizona’s offensive line ranks above league average in Pass Protection Win Rate

With a majority of Arizona’s secondary dealing with injuries, Sam Darnold will have a great opportunity to build on his momentum as he has been one of the most efficient quarterbacks in the league through the first three weeks of the season. Especially if Will Johnson is ruled out, leaving the Cardinals' back end vulnerable to getting beat through the air at a consistent rate.

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TNF Prop Bets Week 4

Best Cardinals vs. Seahawks Prop Bets in TNF Week 4

Sam Darnold Over 220.5 Passing Yards (-112) at Caesars Sportsbook

Even though the Arizona Cardinals' injury-riddled defense held the San Francisco 49ers to just 16 points, their back end struggled to play at a competitive level as Mac Jones picked them apart for a total of 284 yards. Unfortunately for the Cardinals' secondary, time is not on their side in week four as the short rest hurts their chances of returning from injury.

The Cardinals' regression on defense bodes well for Sam Darnold as he heads into Thursday night’s NFC West divisional matchup ranked top-10 in Quarterback EPA per play while leading the league in Quarterback PFF Grade. With the contest expected to be close as the current spread implies, Darnold may also avoid losing out on pass attempts to a run heavy game script.

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Sam Darnold Over 19.5 Pass Completions (-130) at FanDuel Sportsbook

To make matters worse for Arizona, their front seven will struggle to generate pressure as they face off against a Seahawks offensive line who has drastically improved in pass protection. Once considered a weakness heading into the year, Charles Cross and Abraham Lucas have managed to play at a very high level as both tackles rank above league average in Pass Block Win Rate.

With Darnold getting the benefit of operating in a clean pocket for a majority of the contest, this will help reduce the amount of Havoc in his throws which increases his chances of completing a pass. The Cardinals' injuries to their secondary will also force their back end to be stretched out thin in coverage which will create higher quality passing lanes for Darnold to exploit.

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Kenneth Walker III Anytime Touchdown (-130) at FanDuel Sportsbook

Not only have the Seahawks' offensive line improved in pass protection, but they also excel at opening up running lanes as their front five ranks above league average in Run Block Win Rate. With Kenneth Walker dealing with less resistance in the trenches, the Seahawks running back has been able to reach the second level of the defense at a more consistent rate as he ranks in the top half of the board in Rushing Yards Over Expected per carry. 

In Thursday night’s contest against Arizona, Walker will be in a great position to generate yards after contact inside the 20 as the Cardinals blitz their linebackers at one of the lowest rates in the league. Even with Zach Charbonnet back from injury, Walker will continue to receive a heavy workload when in scoring position as he also leads the team in Total Red Zone Carries.

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Kyler Murray Longest Completion Under 33.5 Yards (-110) at BetMGM Sportsbook

With the Seahawks' defensive line ranking top-3 in Pass Rush Win Rate, Kyler Murray will have less time in the pocket to let his plays develop which hurts his chances of generating an explosive play. Especially with the Seahawks also blitzing their linebackers at a low rate as this gives them extra bodies in coverage to help lessen the width of Murray’s passing lanes.

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More NFL Week 4 Stories

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Kody Malstrom WSN Contributor

Kody Malstrom

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Kody Malstrom is a sports betting journalist with six years of writing experience in the industry. He covers an abundance of sports, including College Football, NFL, College Basketball, NBA, and more. Born and raised in Michigan, Kody is a devoted Detroit Sports fan and spends his Sundays rooting for the Detroit Lions while telling himself this year is the year they win it all. When not staring at betting markets, Kody spends his free time at the beach in the summer or snowboarding in the winter.
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