NFL Week 16 Odds: Odds and Betting Lines for Every Game

• The Broncos are in control of the top seed in the AFC

• Rams vs Seahawks will decide the top seed in the NFC

• The Patriots will face the Ravens on Sunday night 

There are just three weeks left in the NFL regular season, and the playoff races are heating up quickly. The Broncos are the top seed in the AFC, and the NFC’s top seed will be decided on Thursday night.

For more info on the league standings, check our latest NFC Championship odds, along with the AFC Championship odds.

The most noteworthy story heading into Week 16 is that the Chiefs have already been eliminated from playoff contention after an 11-year postseason run. Here, we will discuss the betting lines and odds for these games as well as the rest of the Week 16 slate. 

NFL Odds for Week 16

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Rams vs. Seahawks Odds, Thursday, 8:15 PM EST

• Rams: Spread -1.0 (-105) | Moneyline -110

• Seahawks: Spread +1.0 (-115) | Moneyline -110

• Total: Over/Under 44.0 (-110/-110)

The Los Angeles Rams beat the Seattle Seahawks by two points earlier in the season. The Seahawks had a chance to win on a game-winning field goal, but it was unsuccessful. 

Nevertheless, Seattle didn’t deserve to win as Sam Darnold consistently turned the ball over throughout the game. The Seahawks barely beat the Colts with Philip Rivers as their quarterback last Sunday. 

Meanwhile, the Rams obliterated the Lions in nearly every phase of the game. I’ll back Los Angeles on the road. 

Eagles vs. Commanders Odds, Saturday, 5:00 PM EST

• Eagles: Spread -6.5 (-110) | Moneyline -300

• Commandos: Spread +6.5 (-110) | Moneyline +240

• Total: Over/Under 44.5 (-110/-110)

The Philadelphia Eagles finally looked like a competent football team last week. They have plenty of momentum heading into their NFC East battle against the Commanders. 

Find more details in our NFC East prediction and odds.

Jalen Hurts completed 80% of his passes for 175 yards and three touchdowns against the Raiders. He should be ready to compete against an inferior Commanders squad. 

Washington just shut down Jayden Daniels, so the Commanders are preparing for next season. 

Packers vs. Bears Odds, Saturday, 8:20 PM EST

• Packers: Spread -1.0 (-110) | Moneyline -120

• Bears: Spread +1.0 (-110) | Moneyline +100

• Total: Over/Under 46.5 (-110/-110)

The NFC North is on the line on Saturday night when the Bears face the Packers. Green Bay is a slight road favorite and is coming off a loss to the Broncos. 

They did beat the Bears two weeks ago, covering the 6.5-point spread. Yet Chicago was competitive throughout the game and had a chance to win at the end. 

The Bears under Ben Johnson are a different animal, and they know what’s at stake in this game. Chicago will even the season series and take complete control of the NFC North. 

Latest NFC North odds can be found here.

Bills vs. Browns Odds, Sunday, 1:00 PM EST

• Bills: Spread -10.0 (-110) | Moneyline -550

• Browns: Spread +10.0 (-110) | Moneyline +400

• Total: Over/Under 42.5 (-110/-110)

The Buffalo Bills are the AFC Championship favorites, and they made a statement on Sunday. The Bills fell behind the Patriots by 21 points, and then rallied to win 35-31. 

Josh Allen and James Cook took over the game, and Buffalo’s defense tightened up in the second half. The Bills’ defense has been an issue this season, but they shouldn’t be tested much by rookie quarterback Shedeur Sanders. 

Chargers vs. Cowboys Odds, Sunday, 1:00 PM EST

• Chargers: Spread +2.0 (-110) | Moneyline +110

• Cowboys: Spread -2.0 (-110) | Moneyline -130

• Total: Over/Under 49.5 (-110/-110)

The Los Angeles Chargers battled back against the Chiefs in Week 15 to knock them out of the postseason. Justin Herbert has been playing through injuries, and despite being unhealthy, he has played well.

Los Angeles is on the verge of a playoff spot, but the Cowboys will be a difficult matchup. Dallas was beaten by the Vikings last week, but they’re very explosive. 

The Cowboys are favored, and they should pull off the win in this contest. Dak Prescott, CeeDee Lamb, and George Pickens will be too much explosiveness for the Chargers to handle. 

Chiefs vs. Titans Odds, Sunday, 1:00 PM EST

• Chiefs: Spread -3.0 (-115) | Moneyline -185

• Titans: Spread +3.0 (-105) | Moneyline +155

• Total: Over/Under 37.5 (-110/-110)

The Kansas City Chiefs haven’t played in many meaningless football games under Andy Reid. They’re in a new spot because their next three games will be pointless, and they won’t have their quarterback, Patrick Mahomes. 

The former MVP tore his ACL and will likely miss all of next season as well. The Titans aren’t alive in the playoff hunt, but they may have more hope than Kansas City at this point. 

Find the latest odds for NFL MVP, and see the top candidates before Week 16 kicks off.

Bengals vs. Dolphins Odds, Sunday, 1:00 PM EST

• Bengals: Spread -1.5 (+100) | Moneyline -115

• Dolphins: Spread +1.5 (-120) | Moneyline -105

• Total: Over/Under 50.5 (-110/-110)

The Bengals and Dolphins don’t play much defense, but they can each score. This should be a game with many touchdowns, given the star power of both offenses. 

Cincinnati has a much better squad, but Joe Burrow must be better than he was last week against the Ravens. Burrow should look to Ja’Marr Chase and Tee Higgins early in this contest, leading to an underdog win. 

Jets vs. Saints Odds, Sunday, 1:00 PM EST

• Jets: Spread +4.0 (-110) | Moneyline +180

• Saints: Spread -4.0 (-110) | Moneyline -220

• Total: Over/Under 40.0 (-110/-110)

Tyler Shough is starting to look like a franchise quarterback for the New Orleans Saints. The quarterback has been outstanding over the past two weeks, leading to two wins. 

The Saints won outright as an 8-point underdog in Week 14, and then followed this up with a victory as a2.5-point underdogg against the Panthers. This has shaken the division to its core, and I’m going to ride New Orleans momentum into Week 16. 

Vikings vs. Giants Odds, Sunday, 1:00 PM EST

• Vikings: Spread -3.0 (-105) | Moneyline -160

• Giants: Spread +3.0 (-115) | Moneyline +135

• Total: Over/Under 44.0 (-110/-110)

JJ McCarthy is the first quarterback to throw multiple touchdowns and rush for one touchdown in three of his first eight starts. As bad as McCarthy has been at times, he has done a solid job in his first season as Minnesota’s starting quarterback. 

The Vikings have an elite defense, which makes them challenging to stop by inferior opponents. The Giants have fired their head coach, and they have a quarterback who is consistently in concussion protocol. 

Minnesota should extend its winning streak on Sunday after rolling the Cowboys in Week 15. 

Buccaneers vs. Panthers Odds, Sunday, 1:00 PM EST

• Buccaneers: Spread -3.0 (-105) | Moneyline -160

• Panthers: Spread +3.0 (-115) | Moneyline +135

• Total: Over/Under 46.0 (-110/-110)

The NFC South title is virtually on the line when the Buccaneers face the Panthers on Sunday. The winner will control their own title destiny, while the loser will have to win out and have help along the way. 

Get a deep dive into NFC South odds and predictions here.

The Buccaneers have lost two consecutive games to the Saints and Falcons. Things couldn’t be much worse in Tampa Bay, but they can still win the division once again. 

The Buccaneers aren’t playing well, but they’re better than Carolina. I expect Baker Mayfield to get his team back on track this week. 

Jaguars vs. Broncos Odds, Sunday, 4:05 PM EST

• Jaguars: Spread +3.0 (-110) | Moneyline +140

• Broncos: Spread -3.0 (-110) | Moneyline -165

• Total: Over/Under 46.0 (-110/-110)

The Jacksonville Jaguars and Denver Broncos are both vying for the top seed in the AFC. Jacksonville has emerged in the conference later, while the Broncos have dominated the AFC since the third week of the season. 

Denver just defeated Green Bay, giving them complete control of the top seed in the AFC. The Broncos have a talented offense and one of the best defenses in the league. 

While Jacksonville is improving by the week, Bo Nix and company look like they’re ready to win the Super Bowl right now. 

Falcons vs. Cardinals Odds, Sunday, 4:05 PM EST

• Falcons: Spread -2.5 (-115) | Moneyline -150

• Cardinals: Spread +2.5 (-105) | Moneyline +125

• Total: Over/Under 48.0 (-110/-110)

The Atlanta Falcons are coming off a win over the Tampa Bay Buccaneers. This win derailed Tampa Bay’s division chances momentarily, so Atlanta should have momentum coming into Sunday. 

Arizona has been plagued by injuries, and their record represents this at 3-11. Jacoby Brissett has been the starting quarterback, and while his stats have been fine, he isn’t in a position to win games. 

Arizona was dominated by Houston last week, and Atlanta has the same capability. 

Steelers vs. Lions Odds, Sunday, 4:25 PM EST

• Steelers: Spread +7.0 (-110) | Moneyline +275

• Lions: Spread -7.0 (-110) | Moneyline -350

• Total: Over/Under 49.5 (-110/-110)

The Pittsburgh Steelers blew the Miami Dolphins off the field on Monday night. Pittsburgh has a lot to play for right now as they’re leading the AFC North with three games remaining. 

The Detroit Lions are on the playoff bubble and must keep winning. They also need some help to make the postseason, so this could be a year they don’t play bonus football. 

Dan Campbell will have his team ready to go, but they can’t be trusted to win by seven points. 

Raiders vs. Texans Odds, Sunday, 4:25 PM EST

• Raiders: Spread +14.0 (-110) | Moneyline +700

• Texans: Spread -14.0 (-110) | Moneyline -1100

• Total: Over/Under 38.0 (-110/-110)

The Houston Texans have been excellent covering the spread against inferior opponents. They’re a 14.5-point favorite, and this is warranted against a bad Raiders team. 

Las Vegas was dominated by the Philadelphia Eagles in Week 15. They should get beaten badly once again against the Texans because of Houston’s elite defense. 

It would be surprising to see the Raiders score two touchdowns on Sunday.

Patriots vs. Ravens Odds, Sunday, 8:20 PM EST

• Patriots: Spread +3.0 (-115) | Moneyline +125

• Ravens: Spread -3.0 (-105) | Moneyline -150

• Total: Over/Under 48.0 (-110/-110)

The Patriots blew a 21-point lead against the Buffalo Bills last Sunday. This win would have given them the division title, so I expect them to respond on Sunday against Baltimore. 

The Ravens are a slight favorite, but the Patriots are a better overall team who will be hungry to rebound. Baltimore must keep winning to stay in the playoff race, but they’re outmatched in this game. 

Lamar Jackson has consistently turned the ball over lately, and this won’t work against New England. 

49ers vs. Colts Odds, Monday, 8:20 PM EST

• 49ers: Spread -6.0 (-110) | Moneyline -270

• Colts: Spread +6.0 (-110) | Moneyline +220

• Total: Over/Under 46.5 (-110/-110)

The San Francisco 49ers and Indianapolis Colts are both vying for a playoff position. San Francisco enters this game in a much better position because they have a quarterback. 

The Colts lost Daniel Jones, so they were forced to sign 44-year-old Philip Rivers. Rivers nearly led the Colts to win over the Seahawks, but it was clear that he was handicapped from an athletic perspective. 

The 49ers should coast to a touchdown win if they can convert in the red zone.

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