Top 10 Best NFL Picks for Week 2 - Odds and Predictions

Week 1 of the NFL season was full of some big surprises – like Antonio Brown is now a New England Patriot and the Cleveland Browns might not be heading to the Super Bowl just yet – and teams’ starting lineups finally got a chance to blow the rust out of their offseason carbs, but now that Week 2 is approaching it becomes time to start thinning the football herd.

Last season, plenty of playoff bound teams endured a shaky first week (see New Orleans Saints, Chicago Bears and Dallas Cowboys), so nobody needs to panic just yet, but two losses in a row is something to be avoided in this league since there are too many other talented teams standing by, ready and willing to take away any loser’s potential playoff spot.

Here are the top ten best picks for Week 2 of the 2019 NFL regular season, and for each we give you the current odds as we briefly predict why the favored team will cover the spread and then we follow that up with how the underdog could surprise the world.

Good luck!

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10) Jacksonville Jaguars at Houston Texans

How to watch

What: Jacksonville Jaguars at Houston Texans

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: NRG Stadium in Houston, Texas

How (TV): CBS

Current Point Spread:

Jaguars +9.5, Texans -9.5

Why the favored team will win:

Sure, the Texans are missing starting running back Lamar Miller (torn ACL), but they demonstrated on Monday Night Football in Week 1 that they have some very capable backups in Duke Johnson and Carlos Hyde.

What the Texans do have that the Jacksonville Jaguars do not is a healthy starting quarterback, Russell Wilson, and since the Jags’ Nick Foles broke his clavicle in Week 1 and won’t be in the lineup for a minimum a couple of months expect that to be the difference in this game.

Jacksonville will most likely take a full game (at least) to get used to rookie backup Gardner Minshew, and even the nine-and-a-half points up front here probably will not help them on Sunday against a well-balanced Texans team that came within seconds of beating the New Orleans Saints in Week 1.

How the underdog could surprise the world:

Chances are the Jacksonville Jaguars will not beat the Houston Texans next Sunday, but the question for this bet is will they lose by ten points or more?

The Jaguars did manage to score 26 points against the Kansas City Chiefs in Week 1 (13 in the fourth quarter), so even with their young quarterback Minshew under center, they can still execute the offensive game plan and come close in this one

Jaguars’ running back Leonard Fournette will have to continue to hit hard from the backfield but find more success in the red zone, last week running the ball 13 times for 66 yards, averaging 5.1 yards per carry, and catching 4 passes for 28 yards, 7.0 yards per reception, but with no touchdowns.

AFC SOUTH 2019 INJURY NOTE:

This year already, the AFC South has been riddled with season (and career) ending injuries.

Besides Miller and Foles, there are the series of injuries that happened to Indianapolis Colts quarterback Andrew Luck that eventually led to his retirement.

Whichever banged up team in this division can fill in the wounded gaps and find the most success while healing up could have a huge advantage down the stretch.

9) Los Angeles Chargers at Detroit Lions

How to watch

What: Los Angeles Chargers at Detroit Lions

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: Ford Field in Detroit, Michigan

How (TV): CBS

Point Spread:

SportsbookLA Chargers -2.5DET Lions +2.5Link
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookLA ChargersDET LionsLink
888Sport NJ-148+120

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Why the favored team will win:

The Los Angeles Chargers proved they could win without holdout running back Melvin Gordon, and his replacement, dual threat running back Austin Ekeler, did just fine in his absence.

Veteran quarterback Philip Rivers proved he is still accurate and effective, completing 25-of-34 for 333 yards and 3 touchdowns with an interception as his Chargers beat the Luck-less Indianapolis Colts in overtime last week by a touchdown, (30-24).

Receiver Keenan Allen had 8 grabs for 123 yards and a touchdown – so the point is this offense is fired up and ready to go, especially against a Detroit Lions team that couldn’t hold onto a 17-3 point lead at the half in Week 1.

How the underdog could surprise the world:

The Matt Patricia-led Detroit Lions are one of those teams that seems close to being good, especially given how well their quarterback, Matthew Stafford, was clicking in Week 1 with rookie tight end T.J. Hockenson, who caught 6 balls for 131 yards and a touchdown.

The rest of the Lions’ receiver corps is nothing to sneeze at either – Kenny Golladay and Marvin Jones now work with slot receiver Danny Amendola and together last week they combined for over 200 yards in the air and two touchdowns.

Detroit’s defense failed them in the fourth quarter, allowing rookie quarterback Kyler Murrayto lead his (up to that point in the game) shaky Arizona Cardinal offense to 18 fourth quarter points and a field goal in overtime, so whatever fell apart there would need to be fixed before the Chargers come to town on Sunday.

8) Philadelphia Eagles and Atlanta Falcons

How to watch

What: Philadelphia Eagles and Atlanta Falcons

When: Sunday, September 15, 2019 at 8:20 p.m. ET

Where: Mercedes-Benz Stadium at Atlanta, Georgia

How (TV): NBC

Point Spread:

SportsbookLA Chargers 0DET Lions 0Link
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookLA ChargersDET LionsLink
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

Sure, it took the Philadelphia Eagles until the third quarter to get moving against the Washington Redskins in Week 1, but once they did it was obvious that their preseason hype was real.

Quarterback Carson Wentz and newly acquired receiver DeSean Jackson, back to wearing his familiar green, hooked up multiple times (and deep – 8 receptions for 154 yards and 2 touchdowns) to let the football world know that these Eagles will indeed be soaring.

Philadelphia’s defense took a while to click in, but they held the Redskins to just a touchdown in the second half and they should have the same success in Week 2 over a Falcons team that couldn’t figure out how to score until the fourth quarter in Week 1.

How the underdog could surprise the world:

Talent-wise, the Atlanta Falcons are a championship franchise waiting to happen, only things keep getting in their way, like injuries last season and in the case of Week 1 this year, Minnesota Vikings’ running back Dalvin Cook, who ran for 111 yards and two touchdowns against them.

There’s no doubt that Falcons quarterback Matt Ryan has talent, as does his number one target, receiver Julio Jones, but the two need to hook up more in the red zone like they did at the very end of the Week 1 game, and the Eagles will not make that trick any easier for them on Sunday.

Head coach Dan Quinn’s 0-1 Falcons could begin to prove that they are a serious playoff contender this season by shutting down Carson Wentz and his Eagles in Week 2, but they will need some help from their defensive side, including linebacker De’Vondre Campbell, who led the team in tackles in Week 1 with 6.

7) Indianapolis Colts at Tennessee Titans

How to watch

What: Indianapolis Colts at Tennessee Titans

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: Nissan Stadium in Nashville, Tennessee

How (TV): CBS

Point Spread:

SportsbookIND Colts +3TEN Titans -3Link
888Sport NJ-104-120

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookIND ColtsTEN TitansLink
888Sport NJ+143-177

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

The typically 9-7 Tennessee Titans must be the real deal this season – watch how they manhandled the much-heralded Cleveland Browns on both sides of the ball by thirty points in Week 1 like it was nothing.

Titans’ quarterback Marcus Mariota is in the fifth year of his rookie contract and he is not going to let the (Andrew) Luck-less Indianapolis Colts get in the way of his big money potential this early in the season with receivers Corey Davis and Tajae Sharpe and the help of talented slot man Adam Humphries.

Running back Derrick Henry should have no problem bringing his Titans to more than 3 points past a Colts team that couldn’t shut down Los Angeles Chargers’ backup running back Austin Ekeler last week.

How the underdog could surprise the world:

Everyone wants to write off the Indianapolis Colts because their franchise quarterback, Andrew Luck, retired.

Big mistake – his replacement, Jacoby Brissett, has been there, done that for the entire season Luck sat out in 2017, so he is ready to take over the show in 2019.

The Colts almost came back and beat the Chargers in overtime last week, and they will use the Titans in Week 2 to prove that it’s business as usual in Indianapolis regardless of who is under center.

6) Cleveland Browns at New York Jets

How to watch

What: Cleveland Browns at New York Jets

When: Monday, September 16, 2019 at 8:15 p.m. ET

Where: MetLife Stadium in East Rutherford, New Jersey

How (TV): ESPN

Current Point Spread:

Browns -2.5, Jets +2.5

Point Spread:

SportsbookCLE Browns -2.5NY Jets +2.5Link
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookCLE BrownsNY JetsLink
888Sport NJ-136+112

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

The Cleveland Browns need to win this Monday Night Football matchup against the New York Jets because their talented defense got spanked by thirty points in Week 1 and it wasn’t supposed to go that way.

Plus, there is too much talent on Cleveland’s offensive roster – second-year quarterback Baker Mayfield, receivers Odell Beckham and Jarvis Landry and hard hitting second-year running back Nick Chubb – to fall two games in a row, and it’s in Week 2 that they will get their bearings straightened out by the 3 points.

Last season, the Browns beat the Jets in Mayfield’s first ever NFL game, so expect them to come into this one ready to do their best to run the score up on a Jets defense that allowed the Buffalo Bills to come back in the fourth quarter and beat them in Week 1.

How the underdog could surprise the world:

These New York Jets are a whole lot better than they were last season, and that’s because their quarterback, Sam Darnold, is in his second year now and looks to be more accurate, throwing for a score and zero picks in his initial outing.

The Jets now have one of the premiere double-threat running backs in the league with Darnold in the backfield, and that’s Le’Veon Bell, of course, who is just getting warmed up after sitting out a season waiting to get paid.

Last week Bell ran the ball 17 times for 60 yards and caught 6 passes for 32 yards and a touchdown, so expect that same offensive show to help the Jets get at least a field goal ahead of these forever-struggling Browns.

5) Arizona Cardinals at Baltimore Ravens

How to watch

What: Arizona Cardinals at Baltimore Ravens

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: M&T Bank Stadium in Baltimore, Maryland

How (TV): FOX

Point Spread:

SportsbookARI Cardinals +13BAL Ravens -13Link
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookARI CardinalsBAL RavensLink
888Sport NJ+480-715

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

Watch the second-year quarterback Lamar Jackson and his Baltimore Ravens tear apart the Miami Dolphins last week 59-10 and you might not think 13 points is that much of a spot.

Jackson proved he could throw the ball as he connected with rookie Marquise “Hollywood” Brown four times for 147 yards and 2 touchdowns, the longest an 83-yarder.

Add to the mix newly acquired running back Mark Ingram and you got the ingredients for a slaughter here.

How the underdog could surprise the world:

Rookie quarterback Kyler Murray did a fine job bringing his team back to a tie against the Detroit Lions in Week 1, and now he is on a roll.

Of course, the Cardinals have a better defense than the Dolphins (who doesn’t?), so Jackson best not expect to run all over them like he did in Miami last week.

And don’t forget, Murray has Larry Fitzgerald to throw to, and there is still a lot of gas left in that ‘old’ man’s tank.

4) Chicago Bears at Denver Broncos

How to watch

What: Chicago Bears at Denver Broncos

When: Sunday, September 15, 2019 at 4:25 p.m. ET

Where: Broncos Stadium at Mile High in Denver, Colorado

How (TV): FOX

Current Point Spread:

Bears +1, Broncos -1

Why the favored team will win:

The Denver Broncos will be overlooked for a while, but Joe Flacco is a Super Bowl Champion and despite their slow offensive start on Monday Night Football, his new Mile High team has the talent to (eventually) get him back to the big game.

Running back Phillip Lindsay is in his second year and is ready to follow up his incredible rookie season when he posted 1,278 total yards from scrimmage and 10 total touchdowns.

The Broncos’ defense, built by general manager John Elway to shut teams down, looked a bit shaky in Week 1 against the Oakland Raiders’ (Antonio) Brown-less passing attack, but a team like the Bears, whose offense looked impotent last Thursday, should be easier to handle.

How the underdog could surprise the world:

This will be the Chicago Bears, take two, and it will not turn out the way it did in Week 1 when they lost at home to the Green Bay Packers.

The Bears’ defense will continue to be fine, and the offense, led by Mitch Trubisky, will use this matchup in Denver to get back to firing on all cylinders.

Chicago is a better team here – they will beat this jumbled together Broncos offense by more than one point, easily, or else they are in huge trouble from the get go.

3) Dallas Cowboys at Washington Redskins

How to watch

What: Dallas Cowboys at Washington Redskins

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: FedEx Field in Prince George’s County, Maryland

How (TV): FOX

Point Spread:

SportsbookDAL Cowboys -4.5WAS Redskins +4.5Link
888Sport NJ-114-107

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookDAL CowboysWAS RedskinsLink
888Sport NJ-220+175

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

If you watched the Dallas Cowboys take apart the New York Giants in Week 1, you would know this one against the Washington Redskins will be just as easy.

Sure, the Redskins gave the Eagles a bit of a scare in the first half of their Week 1 game, but by the end it was obvious that Washington still has a ways to go until they are a serious NFC East contender.

Unlike the Cowboys – who looked like they were in Week 10 already, with quarterback Dak Prescott proving he is worth more money and running back Ezekiel Elliott proving he is worth every dime owner / general manager Jerry Jones just paid him.

How the underdog could surprise the world:

Redskins quarterback Case Keenum proved he was still legitimate by completing 30-of-44 passes for 380 yards and 3 touchdowns against the mighty Philadelphia Eagles last week.

Receiver Terry McLaurin had 5 catches for 125 yards and a touchdown in Week 1.

Head coach Jay Gruden is counting on a healthy running back Derrius Guice over veteran Adrian Peterson, so it remains to be seen if the second-year player will be able to excel against the Cowboy rush defense, currently ranked 24th after one game.

2) Minnesota Vikings at Green Bay Packers

How to watch

What: Minnesota Vikings at Green Bay Packers

When: Sunday, September 15, 2019 at 1:00 p.m. ET

Where: Lambeau Field in Green Bay, Wisconsin

How (TV): FOX

Point Spread:

SportsbookMIN Vikings +3GB Packers -3Link
888Sport NJ-110-110

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Money Line

SportsbookMIN VikingsGB PackersLink
888Sport NJ+123-150

* 21+ | NJ only | If you or someone you know has a gambling problem, call 1-800-GAMBLER

Why the favored team will win:

The Green Bay Packers went to Chicago in Week 1 and beat the Bears against what everybody predicted.

What shocked many experts was how effective Mike Pettine’s defense was, Packers keeping the Bears to just a field goal in four quarters of play.

They will repeat their performance and keep Kirk Cousin’s Vikings to just a couple of scores while Aaron Rodgers will continue getting used to his new tight end target, Jimmy Graham.

How the underdog could surprise the world:

The Minnesota Vikings easily took care of the Atlanta Falcons in Week 1, 28-12, and Cousins let his running back, Dalvin Cook, do all the heavy work.

Cook ran the ball 21 times for 111 yards and 2 touchdowns and even caught two passes for 9 yards.

Vikings receivers Adam Thielen and Stefon Diggs will have to step up this time against a Packers’ secondary ranked 10th in the league so far.

1) New Orleans Saints at Los Angeles Rams

How to watch

What: New Orleans Saints at Los Angeles Rams

When: Sunday, September 15, 2019 at 4:25 p.m. ET

Where: Los Angeles Memorial Coliseum in Los Angeles, California

How (TV): FOX

Current Point Spread:

Saints +3, Rams -3

Why the favored team will win:

Welcome to a flashback of the 2018-19 NFC Championship game and most likely a preview of the one this 2019-20 season.

Last year it turned out nicely for the Los Angeles Rams, but that was helped greatly by a blatant pass interference call that was missed.

Running back Todd Gurley is back (his second half against the Carolina Panthers last week was epic) and so is Cooper Kupp, so expect Jared Goff’s and Sean McVay’s offense to shine in the California sun.

How the underdog could surprise the world:

Whenever the New Orleans Saints are the underdogs and Drew Brees is still on the roster, take the bet, a perfect example being the last minute drive he orchestrated in Week 1 against the Texans to set up kicker Wil Lutz to boot the game winning 58-yarder.

It’s a cross-country away game for the Saints so expect that to slow them down a bit, but Brees and his main target Michael Thomas should remain unaffected.

Dual threat running back Alvin Kamara does everything well, and now he has big man Latavius Murray as his backfield partner, so it will be up to the Rams to stop the Saints powerful ground attack, something they struggled to do last week against the Panthers and their own soft-handed back, Christian McCaffrey.

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