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Best Jonathan Taylor Player Props for for Colts vs. Cardinals in Week 6

Published: October 11, 2025, 10:30 AM ET
5 min read
  • Jonathan Taylor is coming off his second three-touchdown game of the season

  • Taylor rushed for a season-low 66 yards against the Raiders in Week 5 but still leads the NFL in rushing

  • Taylor has amassed at least 20 receiving yards in four of his five games this season

For fans of prop bets, who better to target than the NFL’s leading rusher? After five weeks, that distinction belongs to Jonathan Taylor of the Colts. Despite coming off a season-low in rushing yards last week, Taylor found the end zone three times in a 40-6 win over the Raiders. He also has 30 more rushing yards than the next closest running back. That gives the Arizona Cardinals a stiff challenge, as they try to contain Taylor and the Colts one week after an epic collapse against the Titans.

Not surprisingly, Taylor is the current favorite to finish the season with the most rushing yards. He’s also the betting favorite to win Offensive Player of the Year honors. From a team perspective, Taylor’s efforts have helped to position the Colts as the favorites to win the AFC South.

Needless to say, now is as good a time as any to make Taylor the target for prop bets. After looking closely at his season, as well as the Arizona defense, we’ve picked out our three favorite props involving Taylor for Indy’s Week 6 matchup against the Cardinals.

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Best Jonathan Taylor Player Props for Colts vs Cardinals

Best Jonathan Taylor Player Props in Week 6

Jonathan Taylor Anytime Touchdown (-225) at bet365 Sportsbook

It’s hard to deny that this has been an unusual season for Taylor when it comes to touchdowns. He had three touchdowns last week and three in Week 3 against the Titans. But those are his only six touchdowns of the season. Other than a receiving touchdown in Week 2, those are his only touchdowns on the season.

Meanwhile, the Cardinals have only conceded three rushing touchdowns all season. They’ve been surprisingly stingy defensively for a 2-3 team. However, on the heels of a three-touchdown performance, it feels safe to bet on Taylor reaching the end zone in Week 6, largely because Taylor is the focal point of the Indy offense and gets enough touches to find the end zone sooner or later.

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Jonathan Taylor Over 89.5 Rushing Yards (-110) at bet365 Sportsbook 

This is a big threshold for Taylor to cross, but that’s to be expected for the NFL’s leading rusher. It’s worth noting that Taylor has been held to 76 yards or fewer in three of his five games. However, in two of the games in which he fell short of that mark, the Colts gave more carries to his backup.

While the Cardinals have lost three in a row, those three losses have come by a combined five points. Even if the Arizona defense is tough against the run, the Cardinals aren’t likely to lose by a big margin, nor are they likely to hold a big lead over the Colts. That means Indianapolis will rely heavily on Taylor, giving him more than enough carries to reach 90 rushing yards, especially since he’s averaging 5.1 yards per carry.

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Jonathan Taylor Over 16.5 Receiving Yards (-110) at bet365 Sportsbook

Taylor has reached at least 20 receiving yards in four of his five games this season, so this feels like a safe bet. Keep in mind that Daniel Jones is Indy’s quarterback. He’s far more likely to check down to his running backs than most quarterbacks, which should give Taylor enough receptions to reach at least 17 yards.

Plus, Taylor is a candidate to take a simple catch out of the backfield and turn it into something special. Just look at his 43-yard reception against the Broncos in Week 2. The kicker is that starting running backs are averaging 35.8 receiving yards per game against the Arizona defense, which is why Taylor should have no problem amassing at least 20 receiving yards against the Cardinals.

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Jonathan Taylor 2025 Stats

  • Carries: 94

  • Yards: 480

  • Yards per carry: 5.1

  • Touchdowns: 6

  • Receptions: 16

  • Receiving Yards: 133

  • Receiving Touchdowns: 1

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

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Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
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