Seattle Seahawks vs San Francisco 49ers: Predictions and Odds (NFL Week 10)

Written by: Mike Lukas
Updated October 14, 2022
12 min read
My prediction for the final score is 49ers 27, Seahawks 20.

Mike Lukas

How to Watch: Seahawks vs 49ers

What: Seattle Seahawks at San Francisco 49ers
When: Monday Night Football, November 11 at 8:15 pm ET
Where: Levi’s Stadium in Santa Clara, California
How (TV): ESPN

In our weekly video podcast, The Green Men call this the game of the year! Be sure to catch up with all their week 10 picks and best bets and see why the Seahawks vs 49 is so exciting.

Latest Point Spread

Sportsbook SEA Seahawks +6.0 SF 49ers -6.0
bet365 NJ -110 -110
DraftKings -110 -110
Caesars NJ -110 -110

Talk about an electrifying Monday Night Football matchup, Week 10 features a showdown between the top two NFC West franchises – the 7-2 Seattle Seahawks and the undefeated 8-0 San Francisco 49ers.

The Seahawks are coming off a big Week 9 home win over the Tampa Bay Buccaneers, while the 49ers are fresh off their eighth win, this one over the shaky Arizona Cardinals last Thursday Night Football.

Seattle does have to travel for this one (but not far) while San Francisco has had plenty of time to rest up, so let’s take a quick peek at how these two NFC West teams measure up against each other for their Week 10 nationally televised shootout.

Also, check out our favorites to win the Super Bowl!

The 7-2-0 Seattle Seahawks

The Seattle Seahawks are as good as their quarterback, Russell Wilson, who, fortunately for the Seattle fan base, is excellent these days, right now ranked the third most productive at his position with 2,500+ total passing yards, 22 touchdowns and just one interception to his name.

The problem with these Seahawks is that they have only beaten one .500+ team, and at times they have looked downright unimpressive, so this matchup with the 49ers will be a decent proving ground against a team that nobody else has defeated.

It’s the Seahawk’s 25th ranked defense that’s the real problem in Seattle these days, something coordinator Ken Norton Jr. is well aware of, and against a 49ers team that explodes on the ground and picks you apart through the air, it will become very obvious if Pete Carroll’s team deserves a spot in the upcoming postseason.

The 8-0-0 San Francisco 49ers

The San Francisco 49ers are the real deal – unbeaten after nine weeks of football, led by quarterback Jimmy Garoppolo, a man who waited patiently in Tom Brady’s shadows for the opportunity to lead his own postseason-bound team.

However, the 49ers’ rushing game is the real deal, with a two-headed attack featuring Matt Breida and Tevin Coleman, right now ranked second in the league as a unit after averaging 171.1 yards on the ground per game.

What makes San Francisco unbeatable, though, is their defense, currently the best overall in the NFL, and they are terrific at covering your receivers while they sack your quarterback and tackle your runners behind the line.

What’s at Stake for Seahawks vs 49ers?

These two divisional rivals have met 41 total times (including 1 postseason game), with Seattle winning 25 of those times and San Francisco winning the other 16 games.

These NFC West foes met twice last season, both times in December, with the Seahawks winning the first matchup 43-16 and the 49ers winning the second one in overtime, 26-23.

If the Seahawks win this matchup, they’ll move to 8-2-0 and because they would have handed the 49ers their first loss, the Seahawks would rise closer to the top of the NFC West.

But if the 49ers come out winners in this one, they’ll be 9-0-0 and remain the only unbeaten team in the NFL as well as continue to rule the NFC West all by themselves.

Questions to Answer

Who’s favored to win this Week 10 Seahawks-49ers matchup?

Which team has a better offense? Defense? Special teams?

Which team’s quarterback is more likely to lead his team to victory?

We’re going to briefly compare the Seahawks and the 49ers next and attempt to answer those questions and more.

Offensive Stats Comparison

Seattle Seahawks Overall Offense

  • Ranked 18th overall in 2018
  • Ranked 4th overall in 2019

Passing attack: The Seattle Seahawks have the 9th ranked passing offense in the league right now, averaging 263.3 yards per game through the air after nine weeks.

Quarterback Russell Wilson is currently under center in Seattle and ranked the 3rd most productive passer in the league having completed 200-of-293 passes for 2,505 yards and 22 touchdowns with 1 interception and a completion percentage of 68.3.

The Seahawks’ leading receiver after nine weeks is Tyler Lockett, who is currently ranked 4th in the league with 59 catches for 767 yards and 6 touchdowns.

Rushing attack: The Seahawks’ rushing attack is ranked 7th in the NFL after averaging 131.7 yards on the ground per game.

Chris Carson is the Seahawks’ best runner and he is currently the 6th in the NFL with 175 carries for 764 yards and 3 rushing touchdowns, averaging 4.4 yards per carry.

Seattle has scored 248 total points this season, or 27.6 per game, which is the 7th best total in the NFL.

Seattle Offensive Injuries

Listed as questionable for Week 10: offensive tackle Duane Brown (biceps), tight end Will Dissly (Achilles), offensive guard Mike Iupati (back) and center Joey Hunt (hip).

Injury notes: guards Jordan Simmons (knee) and Ethan Pocic (back), running back Adam Choice (undisclosed), tight ends Ed Dickson (knee), Will Dissly (Achilles) and Justin Johnson (Achilles), center Justin Britt (knee – ACL) and offensive tackle Demetrius Knox (knee) have been placed on injured reserve.

San Francisco 49ers Overall Offense

  • Ranked 16th overall in 2018
  • Ranked 7th overall in 2019

Passing attack: San Francisco has the 22nd best passing attack in the league right now after averaging 219.1 yards through the air each game.

Quarterback Jimmy Garoppolo is the 21st most productive NFL passer after completing 160-of-226 passes for 1,806 yards and 13 touchdowns with 7 interceptions and a completion percentage of 70.8.

The 49ers’ best receiver is currently tight end George Kittle (who is listed as questionable in Week 10, see below), who has caught 46 passes for 541 yards with 2 touchdowns in nine weeks, ranked 24th among NFL receivers right now.

Rushing attack: San Francisco has the 2nd ranked rushing attack, so far averaging 171.1 yards on the ground per game.

Matt Breida (who is listed as questionable for Week 10, see below) is the 49ers’ best runner and now he is the 15th most productive in the NFL with 99 carries for 524 yards and 1 touchdown, averaging 5.3 yards per carry.

San Francisco has scored 235 points in 2019, averaging 29.4 per game, which is currently the 3rd highest scoring average in the NFL.

San Francisco Offensive Injuries

Listed as questionable for Week 10: running backs Matt Breida (ankle) and Raheem Mostert (knee), offensive tackles Joe Staley (lower leg) and Mike McGlinchey (knee), tight ends George Kittle (knee) and Levine Toilolo (groin) and placekicker Robbie Gould (quadriceps).

INJURY NOTES: tight end Garrett Celek (back) is listed as PUP-R, while running back Jerick McKinnon (knee – ACL), wide receivers Jalen Hurd (back), Shawn Poindexter (knee) and Trent Taylor (foot) and offensive tackles Shon Coleman (ankle) and Andrew Lauderdale (undisclosed) have been placed on the injured reserve list.

Offensive Advantage

The Seattle Seahawks have a slightly more effective offense balanced nicely between the passing and running game, so they will have a slight offensive advantage on Sunday night, but beware the 49ers’ two-headed rushing monster, as it could totally offset all advantages.

Defensive Stats Comparison

Seattle Seahawks Overall Defense

  • Ranked 16th overall in 2018
  • Ranked 25th overall in 2019

Pass coverage: The Seahawks have the 28th best pass defense in 2019 so far, allowing opponents to throw for just 278.1 yards through the air per game.

Seattle’s defense has 7 team interceptions and they have 15 sacks total.

Run coverage: The Seahawks are the 13th best NFL team against the run right now after allowing opponents to run for 102.7 yards per game.

Seattle has allowed their opponents to score just 230 total points, or 25.6 per game, which is the 22nd least in the NFL.

Seahawks Defensive Players to Watch

Seattle Seahawks’ middle linebacker Bobby Wagner has the 3rd most tackles in the NFL right now, with 86 total (5 for a loss), 2.0 sacks, 3 quarterback hits, 2 passes defended, a forced fumble and a fumble recovery.

Make sure you check out Seahawks’ linebacker Mychal Kendricks, who has 3.0 sacks, 2 quarterback hits, an interception, 5 passes defended, a forced fumble and 45 total tackles (6 for a loss).

In the Seattle secondary is a free safety worth watching, Tedric Thompson, so far with 2 interceptions (the most of any Seahawks), 4 passes defended and 19 total tackles.

Seahawks Defensive Injuries

Listed as questionable for Week 10: defensive ends Jadeveon Clowney (toe) and Quinton Jefferson (oblique), linebacker K.J. Wright (knee) and safeties Quandre Diggs (hamstring) and Delano Hill (shoulder).

Injury notes: defensive tackle DeMarcus Christmas (back) is listed as PUP-R, while defensive tackle Nazair Jones (knee), linebacker Emmanuel Ellerbee (undisclosed), cornerbacks Jeremy Boykins (undisclosed) and Kalan Reed (neck) and safety Tedric Thompson (shoulder) have been placed on injured reserve.

San Francisco 49ers Overall Defense

  • Ranked 13th overall in 2018
  • Ranked 1st overall in 2019

Pass coverage: The 49ers’ defense is best against the pass, allowing their opponents to throw for an average of 138.1 yards per matchup.

San Francisco’s defense has 7 interceptions on opposing quarterbacks and they have 30 total sacks after nine weeks.

Run coverage: The 49ers are 14th best against a rushing attack, allowing opponents to run for an average of 102.9 yards per game.

San Francisco has allowed their opponents to score 102 total points this season, or 12.8 per matchup, which is 2nd fewest in the NFL.

49ers Defensive Players to Watch

The best tackler on the 49ers defense is middle linebacker Fred Warner, so far with 48 total tackles (2 for a loss), 1 quarterback hit, 3 passes defended and a forced fumble.

Definitely check out defensive end Nick Bosa, the rookie phenom with 7.0 sacks, 13 quarterback hits, an interception, 2 passes defended, a forced fumble, a fumble recovery and 21 total tackles (11 for a loss).

Always best to keep an eye out for veteran cornerback Richard Sherman, who right now has 3 interceptions (T-4th most in the NFL) with one of those going for a 31-yard pick-six, 11 passes defended and 29 total tackles.

49ers Defensive Injuries

Listed as questionable for Week 10: defensive end Dee Ford (quadriceps) and cornerback Ahkello Witherspoon (foot).

INJURY NOTE: defensive end Kentavius Street (knee) and cornerbacks Tim Harris (groin) and Jason Verrett (knee) and linebacker Kwon Alexander (pectoral) have been placed on injured reserve.

Defensive Advantage

These 49ers have the best overall defense in the league right now (plus a Bosa brother thrown in there) so they have the defensive advantage over the Seahawks on Monday night.

Special Teams Stats Comparison


Seattle’s punter, Michael Dickson, is in his second NFL season, both with the Seahawks, and this year he has punted 38 times for a net average of 40.9 yards per punt, 28th best in the NFL right now.

San Francisco’s punter, Mitch Wishnowsky, is in his first NFL season and so far, he has punted 25 times this season for a net average of 42.3 yards per punt, which is 14th best in the league.


Seattle’s placekicker Jason Myers is in his fifth NFL season, his first with the Seahawks.

Myers is 12-for-17 in 2019, his longest a 54-yarder, and he has missed two extra point attempts (24/26).

San Francisco’s placekicker, Robbie Gould, is in his fifteenth NFL season, his third with the 49ers.

Gould has made 13-of-20 field goals so far this season, his longest a 47 yarder, and so far, he has missed zero extra point attempts (26/26).

Punt Returners

Seattle’s punt returner, wide receiver Tyler Lockett, is ranked 43rd in punt return average in 2019.

Lockett has returned 12 punts for 46 yards and no touchdowns, averaging 3.8 yards per return, his longest for 10 yards.

San Francisco’s punt returner, wide receiver Richie James, is ranked 9th in average punt return yardage this season.

James has returned 22 punts for 231 yards, averaging 10.5 yards per return, his longest for 32 yards.

Special Teams Advantage

Neither placekicker seems all that accurate at this point in the season, but the 49ers have a better punter and punt returner, so they will have a slight special teams advantage on Monday night.

Final Game Analysis

Why Will the Seahawks Win this Game?

The Seattle Seahawks can win this one if Russell Wilson has a huge game – he needs at least one deep touchdown pass to rookie receiver D.K. Metcalf while Tyler Lockett roams the middle of the field for openings, not an easy ask against the best pass defense in the league.

To win, of course, the Seahawks’ defense will have to figure out a way to stop both heads of the 49ers’ double-barreled running game, and that’s something that their 13th ranked rush defense has proved they are capable of, at least at times.

Tough matchup for Pete Carrol’s bunch, but find a way to penetrate their stellar defense and keep Wilson safe and it might be possible to steal a road win from these over-confident 49ers.

Why Will the 49ers Win this Game?

The San Francisco 49ers will win this one by doing what they always do – hog the field with their run game and choke their opponents with their suffocating defense, something that will be even easier to do in front of a hometown crowd.

Jimmy Garoppolo has to have another decent game distributing the ball to his playmakers – and with his team well rested (and mostly healthy) having not played since last Thursday night, this should not be a problem for anyone.

Bottom line, the 49ers are a better team than the Seahawks right now (better defense, better run game, respectable ball handler under center) so if they just show up and execute, this one should be a grabbable win for Kyle Shanahan’s team.

This Game Goes to the

San Francisco 49ers by a touchdown – their suffocating defense will strangle Russell Wilson and their rushing attack will find the end zone multiple times.

John Breech of CBS Sports predicts the score as 49ers 30, Seahawks 27.

My prediction for the final score is 49ers 27, Seahawks 20.

Seattle Seahawks vs San Francisco 49ers – Game Odds

The odds for this match between the Seahawks vs 49ers are provided by  bet365 NJ, DraftKings Sportsbook, and Caesars NJ.

Good luck!

Money Line

Sportsbook SEA Seahawks SF 49ers
bet365 NJ +215 -260
DraftKings +210 -245
Caesars NJ +225 -215
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Mike Lukas

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Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager.
Nationality: American
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