Champions League Best Bets: Matchday Three, October 21-22

• The league phase of the 2025/26 Champions League continues this week

• Eighteen games will be held across Europe on Tuesday and Wednesday 

• Real Madrid vs Juventus is the standout fixture of the matchday three action

Champions League Matchday Three Odds

The odds for the Champions League Matchday Three contained in this article are taken from the bet365 sportsbook. Use our promo code WSN365 and get your welcome bonus: Bet $5, get $200 in bonus bets win or lose.

Bayer Leverkusen vs. PSG Best Bets

Second Half Higher Scoring (+106) at bet365

Paris Saint-Germain reasserted their credentials on matchday two, coming from behind to beat Barcelona 2-1 despite being without several key players.

That result was a real statement of intent from Luis Enrique’s side, who are determined to lift the trophy for a second season on the bounce.

Bayer Leverkusen have had a more mixed start to their continental campaign with back-to-back draws with Copenhagen and PSV.

Leverkusen need to get a win on the board sooner rather than later, but it will be tough to do that against PSG.

The German side will look to keep things tight early on in a bid to frustrate the holders. This game might only open up in the second half.

Bet $5 at bet365 and Get $200 in Bonus Bets

Arsenal vs. Atletico Madrid Best Bets

Arsenal to Win (-167) at bet365

Arsenal are going for glory in the Premier League this season. Winning the title for the first time since 2004 is their primary objective.

However, the Gunners are also among the leading contenders to go all the way in Europe’s foremost competition. They reached the semi-finals in 2024/25 and pushed PSG hard over two legs.

Arsenal have won both matches so far this term, dispatching both Athletic Bilbao and Olympiacos by two goals to nil.

Atletico Madrid have won one and lost one up to now. Their last visit to England ended in a 3-2 defeat by Liverpool, and we expect them to come unstuck on matchday three as well. Arsenal should have too much for Atletico at the Emirates Stadium.

Get $200 in Bonus Bets When Betting $5 at bet365

Chelsea vs. Ajax Best Bets

Both Teams to Score (-125) at bet365

Chelsea are back in the Champions League having missed out for the past two campaigns, and they do not intend to merely make up the numbers at Europe’s top table.

Winners of the Conference League and the Club World Cup last season, Chelsea are now aiming to triumph on the biggest stage of all.

Enzo Maresca’s men went down to a 2-1 defeat by Bayern Munich on matchday one, but they bounced back by beating Benfica 1-0 last time out.

As for Ajax, the Dutch giants are not at the peak of their powers right now. They are third in the Eredivisie and have lost both Champions League encounters, first to Inter and then to Marseille.

Ajax are yet to score in this competition, but against Chelsea’s weakened backline they have a chance of doing so. The Blues have looked ropey defensively of late, so that gives Ajax a sliver of hope.

Claim $200 in Bonus Bets at bet365 With a $5 Wager

Bayern Munich vs. Club Brugge Best Bets

Bayern Munich/Bayern Munich Half-Time/Full-Time (-150) at bet365

Bayern Munich won the Bundesliga title last term, but they could only manage a run to the quarter-finals of the Champions League.

Vincent Kompany’s team will be aiming to at least reach the semis this time around, with the manager likely to be judged on how his team perform in Europe above all else.

Club Brugge are a decent side, but they will be up against it at the Allianz Arena this midweek.

Bayern’s attacking firepower should help them to take the lead in the first half. From there, Bayern would be strong favourites to win.

We anticipate the German powerhouses being ahead after both 45 and 90 minutes as they aim to maintain their 100 percent record in the Champions League.

Wager $5 at bet365 and Claim $200 in Bonus Bets

Real Madrid vs. Juventus Best Bets

Real Madrid to Win First Half (+105) at bet365

Real Madrid are ready to welcome Juventus to the Estadio Santiago Bernabeu in a battle between the biggest club in Spain and the biggest club in Italy.

While Juve are the most successful side in Serie A history, they have only ever won two Champions Leagues.

Madrid, on the other hand, are by far and away the most successful side in the history of this event, having lifted the trophy on no fewer than 15 occasions.

Xabi Alonso’s team have six points from six in the league phase, as Madrid aim to secure a top-eight finish. Juventus, meanwhile, have drawn both of their outings to date.

The Bianconeri would settle for a point this week, but they will find themselves under the cosh against Madrid, who will look to hold an advantage at half-time.

Grab $200 in bonus bets at bet365 With Our Promo Code WSN365

How to Watch Champions League Matchday Three

• Location: Europe

• Dates: Tuesday, October 21 - Wednesday, October 22

• How to Watch: Paramount+