Most Likely Upsets March Madness 2025 - Elite 8

The Sweet 16 brought us some incredible matchups and set up one of the most exciting Elite 8 rounds yet. With four games on the board, one in particular has upset written all over that. We’ll share which game is below and why we are locking in our bet. Below, we will share our two favorite upset picks for the Elite 8.

Below, we will share our two favorite upset picks for the second round of March Madness. We’ll share our reasoning behind each, along with the latest odds from Caesars Sportsbooks. If you are looking to sign up with Caesars to bet on March Madness, be sure to use promo code WSNDYW to claim a Bet $1, Get Ten 100% Profit Boost Tokens offer!

#2 Michigan State Spartans vs. # 1 Auburn Tigers

Odds Courtesy of Caesars Sportsbooks. 

We have been all over this Michigan State team since Selection Sunday. The team won the regular season in the BIG 10, thanks mainly to their ability to play suffocating defense. That includes the ability to guard the three, leading the conference by allowing a 28% shooting percentage beyond the arc.

The Spartans' ability to guard the three makes their inability to shoot from deep less of a problem. This keeps opponents from pulling away, which is how they averaged 65 points allowed per game during the tournament. They shut down Ole Miss on Thursday after dominating a great New Mexico offense last week.

Auburn faced a tough test in the Sweet 16 when they took on Michigan. The game was close for a long time, but the Tigers pulled away in the second half to win 78-65. That may work against the Woverines, but won’t against a Spartan team that dominated them twice during the regular season.

Look for MSU to slow this game down early, throwing Auburn off their game. It may be close, but the Spartans will control this game.

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