Champions League Best Bets: Matchday Four, November 4-5

• The league phase of the 2025/26 Champions League continues this week

• Eighteen games will be held across Europe on Tuesday and Wednesday 

• Paris Saint-Germain vs Bayern Munich is the standout fixture

Champions League Matchday Four Odds

The odds for the Champions League Matchday Four contained in this article are taken from the bet365 sportsbook. Use our promo code WSN365 and get your welcome bonus: Bet $5, get $200 in bonus bets win or lose.

Paris Saint-Germain vs. Bayern Munich Best Bets

Bayern Munich to Win (+180) at bet365

Paris Saint-Germain and Bayern Munich are undoubtedly two of the best sides in Europe right now, so it will be interesting to watch them go at it at the Parc des Princes. At least one of the pair is guaranteed to lose its 100 percent record in the Champions League this term - and we think it will be PSG.

Luis Enrique’s team will not go down without a fight, but Bayern are in sensational form right now. Vincent Kompany’s crew are 15-0-0 in all competitions in 2025/26, and they have the quality to emerge victorious in the French capital.

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Liverpool vs. Real Madrid Best Bets

Kylian Mbappe to Score Any Time (-120) at bet365

Trent Alexander-Arnold returns to Anfield this week as Liverpool host Real Madrid. The former Reds right-back is likely to receive a hostile reception from a set of supporters which once sang his name with gusto, and the mood could sour further if Real Madrid have a successful night on the pitch. That looks likely given Liverpool’s ongoing vulnerabilities.

Arne Slot’s side have been shaky at the back since the start of the season. That only increases the chances of Kylian Mbappe making his mark at the home of the six-time European champions. Mbappe is in fantastic form, having scored 18 goals in 14 games in 2025/26. A 19th strike awaits on Tuesday.

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Manchester City vs. Borussia Dortmund Best Bets

Both Teams to Score (-175) at bet365

Manchester City ran out 3-1 winners against Bournemouth on Sunday to retake second spot in the Premier League. Pep Guardiola’s side are still not back to their very best, but former Borussia Dortmund striker Erling Haaland is in the form of his life. It is hard to envisage BVB shutting out their former star here.

At the same time, Niko Kovac’s team should have enough about them to find the back of the net. After all, City are not currently as defensively secure as they once were. Dortmund are unlikely to win at the Etihad Stadium, but they should at least trouble the scoresheet.

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Newcastle United vs. Athletic Bilbao Best Bets

Under 2.5 Goals (+100) at bet365

Newcastle United endured yet more misery on their travels at the weekend, going down 3-1 to West Ham United. Currently a lowly 13th in the Premier League table, Eddie Howe’s team are yet to win at a rival stadium. They did at least manage to do so in the Champions League, but Newcastle’s home form will be pivotal to their chances of progression.

Another area where the Magpies are struggling is at the top end of the pitch, with only 10 goals in 10 league games. Again, that has been less of a problem in Europe, but Athletic Bilbao will make life difficult for Newcastle here. Goals could be at a premium at St James’ Park.

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Atletico Madrid vs. Union Saint-Gilloise Best Bets

Atletico Madrid -1 Handicap (-138) at bet365

Atletico Madrid have had a mixed start to their Champions League campaign, losing away to Liverpool and Arsenal in between a 5-1 victory over Eintracht Frankfurt. Thankfully for Diego Simeone the upcoming fixture list looks less daunting for his team, aside from a clash with Inter later this month.

Atletico are likely to brush aside Union Saint-Gilloise without too much difficulty. The Belgians have lost their last two Champions League games by four goals to nil against Inter and Newcastle. It is well within Atletico’s grasp to triumph by a two-goal margin at least.

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Slavia Prague vs. Arsenal Best Bets

Arsenal to Win to Nil (-111) at bet365

Arsenal’s defense is the most watertight in Europe at present. The Gunners have conceded only three goals in 15 matches across all competitions in 2025/26, while they have kept a clean sheet in seven consecutive games in the Premier League, EFL Cup and Champions League. Scoring against this Arsenal team is incredibly difficult.

Slavia Prague will try to breach their backline on Tuesday, but Arsenal are an immovable object and we reckon they will stand firm. Mikel Arteta’s team can register another defensive shut-out here, and they are also likely to pick up all three points to maintain their 100 percent record in the Champions League.

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How to Watch Champions League Matchday Four

• Location: Europe

• Dates: Tuesday 4 November 2025 - Wednesday 5 November 2025

• How to Watch: Paramount+