The Michigan State Spartans prepare for a high stakes second round clash against the Louisville Cardinals on Saturday, March 21, 2026. This battle between tradition-rich programs at the KeyBank Center determines who will advance to the Sweet 16.
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The Michigan State Spartans enter the second round as the No. 3 seed in the Midwest, following a commanding 92–67 win over North Dakota State. Tom Izzo’s squad is led by the elite playmaking of Jeremy Fears Jr., who is currently averaging 9.2 assists per game.
They face a Louisville Cardinals team that has undergone a massive resurgence under Pat Kelsey, sporting a top 20 offense that averages nearly 85 points per game. This matchup features a fascinating contrast between Michigan State’s disciplined half court defense and Louisville’s relentless transition attack.
| Team | Spread | Moneyline | Total (O/U) |
|---|---|---|---|
| Louisville | +4.5 (-110) | +154 | Over 151.5 (-105) |
| Michigan State | -4.5 (-110) | -190 | Under 151.5 (-115) |
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Odds taken on March 20, 2026, at 11:45 AM ET.
Date & Time: Saturday, March 21, 2026, at 2:45 PM ET
Location: KeyBank Center, Buffalo, NY
TV Channel & Streaming: CBS, Paramount+, Fubo
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