Giants vs. 49ers Same Game Parlay Picks: One of the NFL’s Underrated Rivalries Returns

• All eight of San Francisco’s games in 2025 have ended with 49 points or fewer.

• The Giants have allowed 10 rushing touchdowns this season.

• Tyrone Tracy will reclaim the starting running back job after the injury to Cam Skattebo.

One game on the Week 9 schedule that’s easy to overlook is the clash between the New York Giants and the San Francisco 49ers. These two franchises have played some classic games over the years, dating back to some memorable playoff matchups in the 1980s. Even some of their more recent regular-season clashes have been barn-burners. Despite the difference in their records this season, this is a game that warrants plenty of attention.

At 2-6, the Giants probably aren’t going to turn things around and make a playoff push. However, Jaxson Dart is becoming a must-see player, and even though he didn’t begin the season as the starter, he’s now the NFL Offensive Rookie of the Year favorite. Meanwhile, the 5-3 49ers are locked in a tight, three-way battle to win the NFC West, which has become one of the NFL’s most interesting division races. 

Best Giants vs. 49ers Same Game Parlay Picks

With the spread of this game being less than a field goal, we should have a close game on our hands. That’s why we’ve picked the Giants-49ers matchup for a same-game parlay.

The odds for our parlay come from Caesars Sportsbook, which offers a wide array of NFL betting options. Caesars is also welcoming new customers by giving them a set of 20 100% profit boosts as soon as they sign up and make a $1 wager. Currently, the odds for our parlay at Caesars are +500.

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Under 48.5 (-109) at Caesars Sportsbook

This is a tough call because the Giants have had the propensity for playing high-scoring games this season. But most of those games have come against good offensive teams. The 49ers, on the other hand, are strong defensively and sluggish offensively. Since both teams are in the bottom half of the NFL in points scored, we’ll lean toward a low-scoring game.

It’s worth noting that none of San Francisco’s eight games this season have reached 50 total points. The four games in which they’ve been favored have averaged just under 39 total points. Keep in mind the Giants are playing with a rookie quarterback and without Malik Nabers and Cam Skattebo. They aren’t likely to make this a high-scoring game, nor are the 49ers, who have only scored more than 21 points twice this year.

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Christian McCaffrey Anytime TD Scorer (-240) at Caesars Sportsbook

This has been an unusual season for McCaffrey, who has been held in check as a rusher but excelled as a receiver. Nevertheless, he’s found a way to score six touchdowns in eight games. Until the Houston defense stifled the 49ers last week, McCaffrey had scored a touchdown in four straight games. Against a subpar New York defense, he should have no problem picking up where he left off and get back in the end zone.

In eight games this season, the Giants have allowed 10 rushing touchdowns. Only the Titans have allowed more rushing touchdowns, which points to McCaffrey having success this week. The opposing running back has also scored a receiving touchdown against the Giants in their last two games. Since that plays into McCaffrey’s strengths, we’re even more confident he’ll score a touchdown this week.

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Tyrone Tracy 50+ Rushing Yards (-132) at Caesars Sportsbook 

The injury to Cam Skattebo should thrust Tracy back into the starting lineup and back into being New York’s bellcow. It’s easy to forget how productive he was last season when he was the team’s top back. In the nine games last season in which he got at least 10 carries, Tracy reached 50 yards seven times. Just two weeks ago, he gained 46 yards on just nine carries against the Broncos.

As long as Tracy gets at least 10 or 12 carries, he should be able to reach 50 yards. That’s a safe assumption with Skattebo out, even if Devin Singletary gets some carries as well. The 49ers have been solid but unspectacular against the run this year, giving up about 108 rushing yards per game. Tracy should get the bulk of that, especially since the Giants won’t need to abandon the run in what should be a close game, making 50 yards an easy target for him.

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