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New England Patriots vs Buffalo Bills Predictions, Odds, Picks

Written by: Mike Lukas
Updated October 14, 2022
13 min read
  • New England Patriots rookie QB Mac Jones has the team on a six game winning streak
  • The Buffalo Bills are coming off a huge Thanksgiving blowout of the Saints, 31-6
  • Buffalo has won against their last nine AFC East opponents

Patriots vs Bills Odds

Patriots Vs Bills Week 13

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Looks like the New England Patriots’ general manager/head coach Bill Belichick has found his next Tom Brady, that being rookie QB Mac Jones who has led the team to a six-game winning streak by playing smart football with an effective offense that averages 28 points per game offset nicely by a 4th ranked defense that can cover the deep ball while getting big sacks.

The Buffalo Bills are coming off a huge Thanksgiving blowout of the Saints, 31-6, with franchise quarterback Josh Allen tossing four touchdowns, passes with two picks, the Bills now with a number one ranked defense, the perfect squad to take on these Patriots in this battle for the AFC East, and whatever game plan HC Sean McDermott creates, GOAT Belichick will counter.

These two AFC rivals have played each other 122 previous times (including 1 postseason game), with the Buffalo Bills winning 45 of those games and the New England Patriots winning 76 of the games, plus there has been a tie.

New England Patriots vs Buffalo Bills Predictions

Can the Patriots Add to Their 6-Game Win Streak?

It takes a lot of skill and luck to win two NFL games in a row, so imagine how much of that mojo is required to create a six game winning streak like the ones the New England Patriots are on right now after starting out their season going 2-4.

Now, rookie quarterback, Mac Jones seems to be more than comfortable playing and executing at the NFL level, his offensive game plans created by the best in the game, head coach Bill Belichick, a crafty future Hall of Fame coach who has believed in Jones from the get go.

Now they face a Bills team that has been hit or miss in their biggest games, so Jones will need big production from his major targets like WRs Nelson Agholor and Jakobi Meyers as well as a solid rushing attack provided by Damien Harris and rookie Rhamondre Stevenson.

Can the Buffalo Bills Defense Continue to Shut Down Opponents?

One of the main factors keeping the Buffalo Bills close in most games is their defense, now ranked first in the NFL after allowing opponents to average just 275 total yards of offense each game, a squad that keeps opponents to just 16.5 points, ranked second behind the Pats.

The Bills defense is filled with playmakers like veteran DEs Jerry Hughes and Mario Addison and star LB Tremaine Edmunds and CBs Cameron Lewis and Levi Wallace, all team leaders who are stepping up this season and forcing opponents to game plan differently.

On Monday night, Buffalo faces a divisional rival who is ranked 7th in the league in points scored after averaging 28 per game, so it will be the perfect test for this defense to see if it is ready to face playoff-caliber competition and figure out a way to shut them down early on.

Patriots Key Player: (QB) Mac Jones

It’s rare when an NFL rookie can contribute to his team right away, but Patriots QB Mac Jones is one of those newbies who has made himself right at home, a Bill Belichick prodigy who has made his New England team better using a solid arm and a comfortable game plan.

But it’s Jones’ confidence and level head that has defenses reeling, so far this season having completed 70.3 percent of his passes, with 268 completions for 2,850 yards and 16 touchdowns with 8 interceptions and an 8-4 record right out of the gate.

The 6’ 3” 217 pound Alabama alum is not necessarily the most athletic player on the team, but he runs his offense with precision and a football IQ that seems beyond his rookie status, the result, no doubt, of playing for such a big school in big games, where confidence is a must.

Bills Key Player: (WR) Stefon Diggs

One of the top wide receivers in the league plays for the Bills, and Stefon Diggs has been in the NFL for seven seasons now, first making a football name for himself with the Minnesota Vikings who drafted him back in 2015 and made him a major part of their offense early on.

Last season Diggs led the league in receptions (127) and receiving yards (1,535) and this season he is having a similarly productive time, so far with 67 catches for 847 yards and 7 touchdowns, just one score less than he had all last season.

Watch for Diggs to play a major role in this AFC East battle on Monday Night, most likely matching up against CB Jalen Mills or JC Jackson, though expect a safety or two to join in on that coverage since neutralizing Diggs is most likely a huge part of Belichick’s game plan.

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How to Watch Patriots vs Bills

Patriots vs Bills Information
Teams New England Patriots vs Buffalo Bills
Location Highmark Stadium in Orchard Park, NY
Time Monday, December 6, 2021; 8:15 PM ET
How to watch ESPN
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Mike Lukas

1204 Articles

Mike Lukas is a retired standup comedian turned freelance writer now living in Dallas, Texas, originally from Cleveland, Ohio. His love for the game of football and all things Cleveland Browns turned Mike into a pro blogger years ago. Now Mike enjoys writing about all thirty-two NFL teams, hoping to help football gamblers gain a slight edge in their pursuit of the perfect wager. Email: [email protected]

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