When you sign-up through links on our site, we may earn an affiliate commission. Learn more >

Image for Tony Garcia Tony Garcia - Updated October 14, 2022

Houston Astros vs Chicago White Sox Predictions, Betting Odds, Picks

  • Rain delay actually gives advantage to Astros
  • Offenses could be on display yet again
  • X-factors to watch

Odds presented by: DraftKings

Team Run Spread Money Line Total
Houston Astros -1.5 (+160)
O 8.5 (-110)
Chicago White Sox +1.5 (-190)
U 8.5 (-110)

Play Fantasy Sports Here!
Houston Astros Vs Chicago White Sox 12 Oct

Houston Astros at Chicago White Sox Pick

After a nearly 24-hour delay, the Astros will try to punch their ticket to the ALCS while the White Sox hope to defend home field and live another day.

The winner gets a matchup with the Red Sox, who eliminated the Rays on a walk-off sacrifice fly on Monday night. Chicago should be familiar with McCullers, but there’s a lot of uncertainty around Rodon.

Because there are fewer question marks, we’re going to take the Astros money line and the over.

Play Fantasy Sports Here!
  • Astros are 4-1 in their last 5 overall
  • Astros are 4-1 in their last 5 vs. a team with a winning record
  • Astros are 12-4 in their last 16 Divisional Playoff games
  • Astros are 5-2 in their last 7 playoff games
  • Astros are 11-5 in their last 16 playoff games as an underdog
  • Astros are 0-4 in their last 4 games as an underdog
  • Astros are 0-6 in their last 6 road games vs. a team with a winning record
  • Under is 6-2-1 in Astros last 9 road games vs. a left-handed starter
  • Astros are 1-5 in the last 6 head-to-head meetings in Chicago
  • White Sox are 7-1 in their last 8 games vs. a right-handed starter
  • White Sox are 7-3 in their last 10 overall
  • White Sox are 1-4 in their last 5 playoff games
  • Under is 7-2-2 in White Sox last 11 home games vs. a team with a winning record
  • Under is 10-4-1 in White Sox last 15 vs. a team with a winning record

Houston Astros vs Chicago White Sox Predictions

Rain delay helps the visitors

Mother nature got in the way for what was supposed to be Game 4 on Monday afternoon. Rain washed it away so now it will be Tuesday, which has changed the nature of this game.

Had it been played Monday, Jose Urquidy would have started. Urquidy is a solid pitcher who had a very nice season, going — 8-3 overall with a 3.62 ERA, 0.99 WHIP, and 90 strikeouts in 107 innings.

His numbers are almost comparable to Lance McCullers Jr., who started and picked up the win in Game 1. But the 26-year-old doesn’t have the playoff acumen as the World Series champion and with an additional day’s rest, McCullers slides into the rotation.

He was nearly flawless in the series opener, throwing 6.2 shutout innings, giving up just four hits while striking out four others.

Carlos Rodon, who was originally scheduled to start Monday, will get the ball on Tuesday. The question now is what will Chicago get out of their crafty lefty?

Rodon has suffered from shoulder soreness and fatigue, making just two starts over the past month, throwing 89 pitches or fewer on each occasion.

So whether he goes one inning or six, the White Sox are better with him on the mound. He threw 132.2 innings, leading the team with a 2.37 ERA and 185 strikeouts.

Could an offensive explosion be in store?

So far in this series, two of the three games have easily gone “over” the total. The one game that didn’t — the opener which had McCullers on the mound — just narrowly missed.

But with McCullers on the mound (and it being later in the series, so every pitch is even more scrutinized) some might expect this to be lower scoring.

However, a white-hot White Sox team just saw his arsenal less than a week ago, so it’s hard to imagine they won’t fare at least somewhat better than they did in the series opener.

On the other side, the White Sox are hoping Rodon can be even a shell of the no-hitter throwing version of himself from earlier this year to prevent the Astros from putting up more crooked numbers.

X-factors to watch

For Houston, the man to watch is Yuli Gurriel. For starters, he got moved down to No. 7 in the lineup for game three (something no competitor wants to have happen) but he happens to rake against lefties.

Gurriel hit .326 (59-of-181) in the regular season, with eight home runs, 34 RBIs and a .925 OPS.

For Chicago, it’s gotta be Jose Abreu. He had two hits in Game 1 vs. McCullers — the only White Sox player to reach base more than once in the first game. He has been the best hitter for Chicago in the series — posting at least one hit and one RBI in all three games.

Play Fantasy Sports Here!

How to watch Houston at Chicago

Event Information
Teams Houston Astros at Chicago White Sox
Location Guaranteed Rate Field, Chicago, IL
Time Tuesday, Oct. 12, 2:07  p.m. EST
How to watch FS1

Latest MLB Articles

Best NRFI Bets Today, November 1

Best NRFI Bets Today, November 1

1 November, 2023 | Tanner Kern
Best MLB Bets Today | MLB Picks, November 1

Best MLB Bets Today | MLB Picks, November 1

1 November, 2023 | Bryan Zarpentine

100% Deposit Match up to $100

21+ CO, VA, MI Only | Terms and conditions apply

Claim Now
Image for Tony Garcia


Tony Garcia

180 Articles

Tony writes about baseball for WSN.com after recently graduating with his Masters from the Medill School of Journalism at Northwestern University. Prior to that, Tony was a local sports reporter for MLive Media Group, based out of Jackson, Michigan where he covered everything from high school to professional sports. He graduated from Michigan State in 2015 with a degree in journalism. During his time there he covered the Michigan State football and men’s basketball teams from 2013-15 and hosted a sports radio show on WDBM 89FM.

More info on Tony Garcia
We've been featured on:
espn logo
reuters logo
cbs-news logo
forbes logo
entrepreneur logo
entrepreneur logo
We only list licensed sportsbooks

© Rebel Penguin ApS 2023 (a subsidiary of Gaming Innovation Group Inc.)

We support responsible gambling. 21+ Only. Gambling problem? Call 1-800-Gambler.

WSN.com is run by iGaming Cloud Inc (a Gaming Innovation Group Subsidiary) and is registered with the New Jersey Division of Gaming Enforcement (DGE) under affiliate vendor ID 89744, with the Indiana Gaming Commission (IGC) under certificate of registration number SWR-000148, approved by the Pennsylvania Gaming Control Board as a gaming service provider, under certificate registration number 117656-1, possesses a Vendor Minor sports betting license from the Colorado Limited Gaming Control Commission (account number 94414163), granted a vendor registration number VR007603-20-001 by the Michigan Gaming Control Board, an interim Sports Wagering Supplier license, under license number SWS 066, issued by the West Virginia Lottery Commission, a sports betting vendor registration, under registration number #100400, issued by the Director of Gaming Licensing and Investigations of the Virginia Lottery to operate in the State of Virginia, and a Vendor Registration issued by the Sports Wagering Committee of the Tennessee Education Lottery Corporation.

Advertising disclosure: WSN contains links to online retailers on its website. When people click on our affiliate links and make purchases, WSN earns a commission from our partners, including ESPN and various sportsbooks.