49ers vs. Eagles Same Game Parlay Picks: Positive Regression Looms Large Over Barkley

• Saquon Barkley was held to just 3.6 Yards per Carry against the Buffalo Bills

• The Philadelphia Eagles are listed as one of the betting favorites to win the NFC

• The San Francisco 49ers rank below league average in Run Defense PFF Grade

After winning the NFL Offensive Player of the Year award last year, Saquon Barkley has fallen hard back down to reality as the Philadelphia Eagles running back is averaging fewer Yards per Carry than he did last season. Luckily for Barkley, he will have a great opportunity to round back into form in Sunday’s playoff matchup against San Francisco as he faces off against a 49ers front seven who struggles to stop the run.

See the favorites and latest odds for NFL Offensive Player of the Year award winner this season.

49ers vs. Eagles Same Game Parlay Picks

Odds for the 49ers vs Eagles matchup in the Wild Card Round are provided by BetMGM Sportsbook, one of our top-rated parlay betting sites. Join BetMGM today with our promo code WSNSPORTS and get up to $1,500 back in the form of bonus bets* should you lose your first wager. Read our BetMGM Sportsbook review for more info.

*21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in DC, MS, NY, NV, ON, or PR.

If you're in a state where BetMGM Sportsbook is not yet legal, we recommend playing at Wanna Parlay. Read our Wanna Parlay review and sign up below with promo code WSNPLAY.

Saquon Barkley Over 80.5 Rushing Yards (-115) at BetMGM Sportsbook

Since the start of the regular season, Saquon Barkley has struggled to play at a competitive level as the Philadelphia Eagles running back ranks below league average in Yards Over Expected per Attempt. A stunning turnaround from the former Offensive Player of the Year award winner when factoring in the support he receives from his offensive line as the Eagles front five ranks top-15 in Run Block Set Grade.

In a highly anticipated playoff matchup against the San Francisco 49ers, expect Barkley to round back into dominant form as he faces off against a front seven who ranks well below league average in Run Defense PFF Grade. For some more exposure, escalator bet Barkley’s Rushing Yardage prop by placing smaller wagers on his alternate overs at the best available odds across multiple sportsbooks.

Use WSNSPORTS at BetMGM for $1,500 Bonus

Saquon Barkley Anytime Touchdown Scorer (-125) at BetMGM Sportsbook

Even though Barkley has struggled in the middle of the field, he has still been the focal point of the Eagles offense when in scoring position as he comfortably leads the team in Red Zone Carries with a 76.8% Usage Rate. With AJ Brown and DeVonta Smith pulling defensive attention away from the middle, the width of Barkley’s running lanes past the trenches will widen which increases his probability of finding the back of the end zone.

Claim $1,500 in Bonus Bets at BetMGM

Jalen Hurts Over 19.5 Pass Completions (-105) at BetMGM Sportsbook

While Barkley has struggled, Jalen Hurts has been able to keep the Eagles competitive as the former Super Bowl MVP ranks above league average in Quarterback EPA per Play and in Turnover Worthy Play Percentage. With the 49ers front seven ranking near the bottom of the board in Pass Rush Win Rate, their lack of pressure will allow Hurts to set his feet instead of having to throw on the run which will drastically increase the quality of his throws.

Claim $1,500 Bonus Offer at BetMGM

Christian McCaffrey Under 59.5 Rushing Yards (-115) at BetMGM Sportsbook

After missing a majority of 2024-25 with an injury, Christian McCaffrey was able to stay on the field this season as he managed to play in all 17 games. While his availability did help him stuff the stat sheet, McCaffrey was very inefficient with his usage as he ranks near dead last in Yards Over Expected per Attempt. Even when running behind an offensive line who ranks top-3 in Line Yards, McCaffrey was unable to extend plays with his legs as he averaged just 3.9 Yards per Carry.

Heading into Sunday, expect McCaffrey to struggle to break through the trenches as he faces off against an Eagles defense who excels at stuffing the run as their above league average mark in Run Defense PFF Grade indicates. With McCaffrey getting bottled up at the line of scrimmage, the 49ers may revert to a heavier dose of the pass to counter their front seven which will chip away at his total number of Rush Attempts.

Join BetMGM and Get Up to $1,500 First Bet Offer