Cardinals vs. 49ers Same Game Parlay Picks: Both Defenses in Need of a Bounce-Back Performance

• Both the 49ers and Cardinals gave up over 40 points in a loss last week.

• Five of Arizona’s six losses this season have come by four points or less.

• Trey McBride has caught five of Jacoby Brissett’s eight touchdown passes this season.

Division rivalry games are a huge theme on the Week 11 schedule, and not to be overlooked is the NFC West clash between the San Francisco 49ers and Arizona Cardinals. Both of these teams need a palate cleanser, as both lost last week while giving up over 40 points. The 49ers, in particular, are very much in need of a win, as they remain in the playoff picture but are trailing both the Rams and Seahawks. That makes this an overlooked but important game on the Week 11 schedule.

As mentioned, the 49ers are starting to slip in the standings, although they are alive in the race to win the NFC West. At the same time, Christian McCaffrey is leading the pack in the NFL Comeback Player of the Year odds. Plus, if the 49ers can get things turned around and make a run to the playoffs, Kyle Shanahan could still factor into the NFL Coach of the Year favorites. 

Cardinals vs. 49ers Same Game Parlay Picks

With so many angles to look at for this game, one bet wasn’t going to be enough. That’s why we decided to put together a three-leg, same-game parlay for the 49ers-Cardinals rivalry game.

The odds for our parlay courtesy of Caesars Sportsbook. Caesars is listed as one of our best parlay betting sites, and on top of that, all new customers who sign up with our Caesars promo code WSN20X will receive 20 100% profit boost tokens just by signing up and placing a $1 bet.

For our parlay, the current odds available at Caesars are: +229.

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Cardinals +4.5 (-164) at Caesars Sportsbook

It’s usually a good idea to take a chance on a home underdog in a division rivalry game. We’ve teased the spread just a little because we’re confident Arizona can at least keep this game close. Despite last week’s 44-22 loss to the Seahawks, Arizona’s five other losses this year have all come by four points or less. The Cardinals have been surprisingly competitive for a 3-6 team, and they’re 4-2 against the spread as an underdog.

Likewise, just a single point separated these teams earlier in the season when the 49ers won 16-15. Even with Jacoby Brissett now starting in place of Kyler Murray for the Cardinals, it’s hard to imagine the 49ers suddenly dominating the Cardinals, especially on the road. After all, they’ve lost three of their last five games and two of their last three games on the road, so it’s tough to get behind San Francisco right now.

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Christian McCaffrey Over 53.5 Receiving Yards (-114) at Caesars Sportsbook

As a rusher, McCaffrey has been hit or miss this season. But he’s consistently put up big numbers as a pass-catcher. There are just two games this season in which he’s been held under 53.5 receiving yards. He’s hit at least 70 receiving yards in five of 10 games, so there is a decent safety net for this pick.

In every game this season, McCaffrey has had at least six targets. Since these are typically short passes, most of them are completions. Since McCaffrey can easily take short passes and turn them into big gains, going over 53.5 receiving yards shouldn’t be an issue. After all, he torched the Arizona defense for 88 receiving yards on 10 catches in Week 3.

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Trey McBride Anytime Touchdown (+125) at Caesars Sportsbook 

Outside of McCaffrey, McBride is the safest anytime touchdown scorer in this game. He’s hauled in six touchdowns this season, scoring at least once in four straight games. It’s also worth noting that Jacoby Brissett has thrown two touchdown passes in four consecutive games, with McBride catching five of those eight touchdowns, so those two clearly have good chemistry.

The kicker is that the 49ers are among the worst at keeping tight ends out of the end zone. Only six teams are allowing more touchdowns per game by opposing tight ends. The 49ers have allowed a tight end touchdown in back-to-back games, while McBride scored against them in Week 3, making him a safe pick to get in the end zone this week.

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