NFL Week 1 - Predictions, Picks, Spreads and Odds 
- Get the most recent odds for NFL Week 1 Games in 2020.
- Our top predictions and picks for the season.
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The NFL schedule makers did a terrific job setting up lots of potential drama and must-see matchups for the first week of the 2020 / 21 season, with all sixteen games stretched out across five glorious days and nights of early September.
There was always a certain level of doubt as to whether the season could even happen due to the national social distancing policy, but NFL commissioner Roger Goodell and the 32 franchise owners got creative and figured out a way to make the regular season commence in a safe and fair environment.
Here we take a look at the predictions and odds of all sixteen of the Week 1 games, with a quick analysis of each matchup.
Houston Texans at Kansas City Chiefs (-10)
Tough not to take a ten-point lead when you’re getting what AFC South champions Texans have on offense – quarterback Deshaun Watson and receivers Brandin Cooks, Will Fuller, Randall Cobb and now David Johnson running and catching out of the backfield.
But these are the AFC and world championship Chiefs we’re talking about – with a freshly paid former MVP Patrick Mahomes under center ready to prove the Super Bowl Curse is a myth and head coach Andy Reid couldn’t agree more.
Prediction: Kansas City
Chicago Bears at Detroit Lions (-1.5)
Big gamble to put early money on this one since nobody has a clue (yet) as to which player will line up as starting quarterback for the Chicago Bears – the oft-troubled Mitchell Trubisky or the oft-injured Nick Foles, but either way this team can win.
The Detroit Lions are more settled at the QB position than the Bears are, but that doesn’t mean Matthew Stafford will suddenly find a way to beat Chicago, something his team hasn’t done the last four times the two have met.
Cleveland Browns at Baltimore Ravens (-7.5)
Last year, as hapless as the Cleveland Browns were, they still beat AFC North rivals Baltimore Ravens during the season, and now that they have (arguably) more capable coaching and a decent front line, expect quarterback Baker Mayfield and company to come out with a bang.
But this is Lamar Jackson and his playoff worthy Baltimore Ravens playing in their home stadium, so the chances of them arriving in Week 1 ready to compete are high, though covering that 8-point spread could be impossible.
Green Bay Packers at Minnesota Vikings (-3.5)
Packers QB Aaron Rodgers typically does not do well in Minnesota, but when these two NFC North teams met in Minneapolis last December the Packers took care of business 23-10.
That said, the Vikings haven’t lost a home opener in over a decade and a half and they should be able to cover the spread in front of a friendly crowd the way they have the last three seasons with head coach Mike Zimmer leading the way.
Indianapolis Colts (-7) at Jacksonville Jaguars
This will be a fun game to watch, since the “fading” Philip Rivers will be playing for a new team for the first time since he entered the league back in 2004, and the shaky Colts could use the same kind of jolt that he could use.
Expect the Jags to finally start to motor forward with the young Gardner Minshew slowly finding his NFL legs under center, especially if young running back Leonard Fournette does the same.
Las Vegas Raiders (-1.5) at Carolina Panthers
The Raiders are not as bad as the sub .500 they played at last season and opening the 2020 season in their new Las Vegas digs should bring some extra energy to their game, which quarterback Derek Carr could certainly use.
The Panthers are dealing with a new head coach (Matt Rhule) and a new quarterback (Teddy Bridgewater) so their effectiveness right out of the gate could totally underwhelm.
Prediction: Las Vegas
Miami Dolphins at New England Patriots (-6.5)
The Dolphins took care of the Patriots when last they met in December of 2019, and that was against the GOAT Tom Brady when the team desperately needed a win to secure a playoff bye.
But the GOAT is gone and Cam Newton (or Jarrett Stidham or both?) is now under center for the AFC East champions, so either Ryan Fitzpatrick or rookie Tua Tagovailoa will have to match snaps with a superstar with a huge chip on his broad shoulders.
Prediction: New England
NY Jets at Buffalo Bills (-6.5)
After two NFL seasons, both teams’ young quarterbacks have settled in by now, though the Jets’ Sam Darnold seems to have had less success than Buffalo’s Josh Allen, who took his Bills to the playoffs last season as a wild card team.
For the fourth year in a row, the 7-9 Jets could not break .500 last season, but with an upgraded front line and receiver room, head coach Adam Gase is looking to prove he deserves to keep his job.
Prediction: New York
Philadelphia Eagles (-6.5) at Washington Football Team
A healthy Carson Wentz will almost always beat a healthy Dwayne Haskins, which is why the Eagles are favored in this NFC East clash by almost a touchdown.
Haskins will theoretically have a healthy Alex Smith to compete with for the job, so there is no telling who will begin the season under center for Washington’s pro football team (or what their mascot might be named by then).
Seattle Seahawks (-1) at Atlanta Falcons
The Falcons finished last season on a 6-2 run that is most likely still on their minds, and if QB Matt Ryan and receiver Julio Jones can continue where they left off, a home opener W should not be a problem.
Except it’s against the Seattle Seahawks, and veteran Russell Wilson will most likely start the season at a high level of play, even on the road, and at top form Atlanta’s defense will struggle to stop him.
LA Chargers (-3.5) at Cincinnati Bengals
As amazing a college quarterback Joe Burrow was, this is the NFL and he is now playing for the miserable Cincinnati Bengals, so don’t look for him to be too impressive during his rookie debut.
AFC West’s Chargers will most likely have journeyman Tyrod Taylor as their Week 1 starting QB, so expect a competent, if not flashy, performance from him.
Prediction: Los Angeles
Arizona Cardinals at San Francisco 49ers (-7)
The Arizona Cardinals have two “aged” but incredibly talented wide receivers in DeAndre Hopkins and Larry Fitzgerald, and with star quarterback (and 2019’s Offensive Rookie of the Year) Kyler Murray entering his second season, expect decent production from them.
But the Cards have to match up against last year’s NFC champions and Super Bowl runner ups and their shut down defense, and the 49ers are every bit as dangerous as they were before, plus now with rookie receiver Brandon Aiyuk.
Prediction: San Francisco
Tampa Bay Buccaneers at New Orleans Saints (-4)
This NFC South clash will be a highly watched matchup, mostly to see what Bucs head coach Bruce Arians can do with all that talent he now has, including GOAT quarterback Tom Brady and his multi-gifted cohort, tight end Rob Gronkowski.
Of course, the Saints are no slouches either, with another “elderly” QB hungry for a Super Bowl ring, Drew Brees, ready to make this (possibly?) final season of his count right from the start, though his team typically starts slowly.
Prediction: Tampa Bay
Dallas Cowboys (-2.5) at LA Rams
Chances are the Cowboys’ franchise tagged QB Dak Prescott will come out of the NFL gate firing on all cylinders to prove he is worth the kind of money another star at his same position just made over in KC.
Pittsburgh Steelers (-3.5) at NY Giants
The entire football world can’t wait to witness the return of “Big” Ben Roethlisberger, the former Super Bowl Champ now 38 years old and healthy after recovering from elbow surgery on his throwing arm.
Even with new head coach Joe Judge and offensive coordinator Jason Garrett, the Giants still look a bit “iffy,” especially on defense, where they improved little on the squad that was ranked 25th at the end of last season.
Tennessee Titans at Denver Broncos (-1.5)
The Titans have become a solid offensive force with Ryan Tannehill under center, his consistent play made even more effective by having the league-leading rusher in his backfield, Derek Henry.
Denver used the draft to improve their offense, adding targets Jerry Jeudy and KJ Hamler to the mix along with center Lloyd Cushenberry III, all added to help improve the effectiveness of their young quarterback, Drew Lock.
Odds updated 3 August, 2020 from DraftKings.
Remember, the point spreads in these wagers will most likely shift several times before the actual games are played, so be sure to check back in often to get all the latest predictions and odds.