Steelers vs. Chargers Same Game Parlay Picks: Is LA’s Injury Report too Much to Overcome in Prime Time?

• Chargers OT Joe Alt will miss the remainder of the season

• Kimani Viadal is the Chargers’ only healthy running back

• The Steelers’ defense posted five sacks, 5 TFLs, 13 PDs, 6 QB hits, and six turnovers

A banged-up Los Angeles Chargers team will be welcoming the Pittsburgh Steelers on Sunday night. Both teams are battling for division titles and playoff positioning in the AFC, making this week’s matchup a crucial one. With high stakes and crowded injury reports, we see a lot of fantastic bets available for a winning same-game parlay. 

Steelers vs. Chargers Same Game Parlay Picks

Below, we will share our favorite same game parlay picks for this Week 10 matchup between the Chargers and Steelers. We’ll provide insights into each leg we’ve selected and provide odds courtesy of BetMGM Sportsbook, one of our top-rated parlay betting sites.

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Pittsburgh Steelers ML (-125) at BetMGM Sportsbook

The Steelers have been wildly inconsistent all season, but they returned to form last week against the AFC South-leading Colts. Their defense was especially impressive, recording five sacks, five TFLs, 13 PDs, six QB hits, and six turnovers. We know the unit can’t deliver this level of play each week, but we believe they are set up to do so again on Sunday Night Football.

The Chargers' offense took another big hit when offensive tackle Joe Alt learned he would need season-ending surgery for an ankle injury. His absence will be a massive blow for the pass game, as the Chargers allowed six sacks when Alt was out last week. They were already short on depth, meaning they won’t be able to do much to stop an overwhelming Steelers defensive front.

Alt’s absence is also a big blow to the Chargers’ run game. Omarion Hampton and several backup running backs are out with injuries, leaving Kimani Vidal as the top option. While explosive, don’t expect much from the reserve back as he struggles to find room to run with Alt out.

The Steelers offense has been reliable all season and will be able to do enough against a good Chargers defense to get the win on Sunday night.

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Justin Herbert Over 279.5 Rush and Pass Yards (-115) at BetMGM Sportsbook

We expect all the pressure to fall squarely on Justin Herbert's shoulders. The NFL MVP candidate has been fantastic using his arm and legs, and will be called on to do both on Sunday night with Joe Alt out and the backfield depleted. We saw him do just that last week, when he passed for 250 while adding another 57 on the ground.

Herbert is averaging 265.5 pass yards and 33.9 on the ground over nine games this season. While he is well known as an elite passer, he is also a deadly rusher, averaging 6.6 YPC in 2025. 

Herbert will be facing a dangerous Steelers defense, but he will be at the center of every play. That volume will allow him to surpass this total with ease.

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Kimani Vidal Over 14.5 Rush Attempts (-118) at BetMGM Sportsbook

The 24-year-old running back is the only healthy running back the Chargers currently have. They will add depth from the practice squad, but Vidal will be the unquestioned top option. We believe this game will be close throughout, meaning the Chargers will need to keep pressing the run. 

The Steelers' run defense ranks around the middle of the league, allowing 105.5 yards per game and a 4.2 YPC average. While they are coming off an incredible showing against the red-hot Jonathon Taylor last week, we haven’t seen them play at that level consistently, making it hard to believe we’ll see a similar performance on Sunday Night Football.

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