NFL Odds Week 12: Odds and Betting Lines for Every Game

• The Chiefs are 5-5 heading into Week 12 and outside the playoffs

• The Broncos and Eagles are the current top seeds in their respective conference 

• Denver, Miami, Los Angeles, and Washington are all idle in Week 12

Legitimate contenders in the AFC and NFC have separated themselves from the pack. The Broncos and Eagles currently hold the top seeds in their respective conferences heading into Week 12, but a lot will happen in the final seven weeks of the regular season. 

There are tons of great games on the Week 12 schedule. Here, we will provide a brief analysis of each matchup in Week 12 and discuss the corresponding odds.

NFL Odds for Week 12

Odds courtesy of bet365 sportsbook. bet365 is ranked as one of our top recommended NFL betting sites. If you bet $5, you get $150 in bonus bets by using our bet365 promo code WSN365 at registration.

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Bills vs. Texans Odds, Thursday, 8:15 PM EST

• Bills: Spread -5.5 (-110) | Moneyline -260

• Texans: Spread +5.5 (-110) | Moneyline +210

• Total: Over/Under 43.5 (-110/-110)

Josh Allen is one of the MVP favorites alongside Drake Maye and Matthew Stafford. Allen had a rough start against the Buccaneers, but finished the game by looking like the most dominant player in the NFL. 

Allen recorded six total touchdowns in the game, which leads me to think that the Texans will face a significant challenge on Thursday. 

The Texans have a solid defense, but they will likely struggle to score enough points to beat the Bills. The line is moving in Buffalo’s direction, so bettors have the same mindset. 

Steelers vs. Bears Odds, Sunday, 1:00 PM EST

• Steelers: Spread +3.0 (-110) | Moneyline +135

• Bears: -3.0 (-110) | Moneyline -160

• Total: Over/Under 44.5 (-110/-110)

The Chicago Bears are 7-3 and leading the NFC North. They’re still picked third in the division, but they’re beginning to look like a solid playoff contender. 

Ben Johnson has transformed this team into a group of winners. The talent was present in Chicago, but they needed a championship mindset. 

The Bears have a great chance to beat the Steelers, as Aaron Rodgers will not play due to a wrist injury. Pittsburgh’s season is in jeopardy now without its starting quarterback. 

Patriots vs. Bengals Odds, Sunday, 1:00 PM EST

• Patriots: Spread -8.0 (-110) | Moneyline -400

• Bengals: Spread +8.0 (-110) | Moneyline +320

• Total: Over/Under 49.5 (-110/-110)

The Patriots hit the jackpot on Sunday because they don’t have to face Ja’Marr Chase. Chase spat in Jalen Ramsey’s face on Sunday, and the NFL suspended him for one game. 

He will forfeit over $500K for missing the game, and his absence will likely be too much for Cincinnati to overcome. The Bengals don’t have a great defense, and they’re still without their starting quarterback, Joe Burrow. 

The Patriots are playing like an AFC East champion, and their quarterback, Drake Maye, has been one of the best players in the NFL. 

Giants vs. Lions Odds, Sunday, 1:00 PM EST

• Giants: Spread +10.5 (-110) | Moneyline +425

• Lions: Spread -10.5 (-110) | Moneyline -575

• Total: Over/Under 49.5 (-110/-110)

The Detroit Lions lost to the Philadelphia Eagles on Sunday night. Detroit’s offensive line was terrible as Jared Goff was pressured consistently throughout the game. 

Goff and the Lions’ offense should be better at home against an inferior Giants team. Jameis Winston will start at quarterback for New York, which means the Lions' defense has an excellent chance of forcing turnovers. 

The Lions are 13-0 straight up and against the spread following a loss since 2022, and this trend should continue. 

Vikings vs. Packers Odds, Sunday, 1:00 PM EST

• Vikings: Spread +6.5 (-110) | Moneyline +235

• Packers: Spread -6.5 (-110) | Moneyline -290

• Total: Over/Under 40.5 (-110/-110)

The Packers beat the Giants last week while the Vikings lost to the Bears. Minnesota isn’t ready to win now because of its young quarterback, JJ McCarthy. 

McCarthy has what it takes to win, but he needs to limit his turnovers, as he already has eight on the season. The Packers have been inconsistent, but they’re much better than Minnesota at this point in the season. 

Seahawks vs. Titans Odds, Sunday, 1:00 PM EST

• Seahawks: Spread -13.0 (-110) | Moneyline -1000

• Titans: Spread +13.0 (-110) | Moneyline +650

• Total: Over/Under 40.5 (-110/-110)

The Tennessee Titans nearly upset the Houston Texans on Sunday. Cam Ward played one of his cleanest games of the season, throwing for 194 yards and one touchdown, but the Texans are lacking explosiveness. 

Seattle doesn’t have this issue, as they have the best receiver in the NFL this season on their side in Jaxon Smith-Njigba. Sam Darnold has too many turnovers lately, but this should change against a lackluster Titans defense. 

The Seahawks gave a game away against the Rams last week, and I expect them to respond. The spread is vast, but it’s worth laying the points. 

Colts vs. Chiefs Odds, Sunday, 1:00 PM EST

• Colts: Spread +3.0 (+100) | Moneyline +150

• Chiefs: Spread -3.0 (-120) | Moneyline -180

• Total: Over/Under 50.5 (-110/-110)

The Kansas City Chiefs are 0-5 in one-score games, and this has been shocking to watch. Last season, the Chiefs dominated tight matchups, but this year they have fallen apart. 

The Chiefs are 5-5 and on the verge of missing the playoffs. They need a win on Sunday, and this will be a challenge against the Colts, who are coming off a bye. 

Indianapolis is competing for the one seed in the AFC, but it’s hard to go against Patrick Mahomes in a must-win matchup. 

Jets vs. Ravens Odds, Sunday, 1:00 PM EST

• Jets: Spread +13.5 (-110) | Moneyline +625

• Ravens: Spread -13.5 (-110) | Moneyline -950

• Total: Over/Under 44.5 (-110/-110)

The New York Jets have benched Justin Fields, and Tyrod Taylor will take over the starting job on Sunday. Taylor gives the Jets a much better chance of winning, but they’re still not on the same level as Baltimore.

The Ravens started the season with an abysmal record, but have battled back and are now favored to win the AFC North. The Ravens have a lot of momentum, and Lamar Jackson is playing like an MVP. 

The Jets don’t have the offense to compete with the Ravens over four quarters. 

Browns vs. Raiders Odds, Sunday, 4:05 PM EST

• Browns: Spread +3.0 (-105) | Moneyline +145

• Raiders: Spread -3.0 (-115) | Moneyline -170

• Total: Over/Under 37.0 (-110/-110)

The Las Vegas Raiders started the season with a victory over the Patriots, but they have since become one of the worst teams in the NFL. The Raiders have more talent than many teams, but they struggle to put the pieces together to achieve success. 

Las Vegas’ most significant issue is that it can’t protect Geno Smith, and it has led to consistent turnovers. The Browns don’t have a great team, but they have one of the best defenses in the NFL. 

Myles Garrett, who is in line to win Defensive Player of the Year, should feast on Geno Smith. 

Jaguars vs. Cardinals Odds, Sunday, 4:05 PM EST

• Jaguars: Spread -2.5 (-115) | Moneyline -155

• Cardinals: Spread +2.5 (-105) | Moneyline +130

• Total: Over/Under 47.5 (-110/-110)

The Jaguars had the most dominant victory of Week 11. They blew the Chargers off the field, and very few people expected this to occur. 

The Jaguars have talent on both sides of the ball, but they’re inconsistent. Nevertheless, if the season were to end today, they would be in the playoffs. 

However, it will be tough to travel to Arizona and win a game, especially after the 49ers rolled the Cardinals. This is a perfect spot for Arizona to respond after a bad loss. 

Eagles vs. Cowboys Odds, Sunday, 4:25 PM EST

• Eagles: Spread -3.5 (-105) | Moneyline -185

• Cowboys: Spread +3.5 (-115) | Moneyline -260

• Total: Over/Under 47.5 (-110/-110)

The Eagles and Cowboys have entirely different styles at this point in the season. The Cowboys rolled the Raiders last Monday, and that’s how they have won games. 

Dallas has a very explosive offense, but it struggles on defense. The Eagles can’t score, but their defense is one of the most devastating units in the NFL. 

The Eagles are a 3.5-point road favorite, and while this is an NFC East game, I’ll side with the better defense and defending Super Bowl champions. 

Falcons vs. Saints Odds, Sunday, 4:25 PM EST

• Falcons: Spread -5.5 (-110) | Moneyline -260

• Saints: Spread -5.5 (-110) | Moneyline +155

• Total: Over/Under 49.5 (-110/-110)

The New Orleans Saints have the edge against the Atlanta Falcons because they’re coming off a bye week. Atlanta lost a heartbreaker to Carolina last week, and their string of tough losses continues to pile up. 

The coaching staff hasn’t been able to channel the talent across the roster, and it’s clear nearly every Sunday. The Saints are looking to 2026 at this point, but their play is improving. 

New Orleans is also traditionally tough to beat at home, so this is a perfect spot for the Saints laying under a field goal. 

Buccaneers vs. Rams Odds, Sunday, 8:20 PM EST

• Buccaneers: Spread +6.5 (-110) | Moneyline +255

• Rams: Spread -6.5 (-110) | Moneyline -315

• Total: Over/Under 49.5 (-110/-110)

The Buccaneers have lost two games in a row and three of their last four. The group looks lost because they scored 32 points last week and forced two turnovers, but the Bills dominated them.

They allowed Josh Allen to score six total touchdowns, and now they’ll face the MVP favorite Matthew Stafford. Tampa Bay will have a hard time winning this game, but they should be able to stay in a position to cover. 

The Buccaneers have been solid over the years traveling to the West Coast, so back the team to keep this game close. 

Panthers vs. 49ers Odds, Monday, 8:15 PM EST

• Panthers: Spread +6.5 (+100) | Moneyline +260

• 49ers: Spread -6.5 (-120) | Moneyline -320

• Total: Over/Under 48.0 (-110)

Brock Purdy returned to the starting lineup for the 49ers last week and was fantastic. The quarterback threw for 200 yards and three touchdowns, while only taking one sack. 

The 49ers are in a perfect position to make the playoffs despite having an injured team. The Panthers are in second place in the NFC South, but they’re not an overly talented football team. 

San Francisco’s defense should have a big game against Bryce Young, leading the team to a win. 

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