NFL Week 15 Odds: Odds and Betting Lines for Every Game

• The Broncos are the current top seed in the AFC

• The Patriots will face the Bills on Sunday 

• The Broncos will battle the Packers at home 

The Rams currently control the NFC Championship race. However, the AFC is up for grabs, and we have two crucial matchups that will help decide the top seed on Sunday. 

The Broncos, who currently hold the top AFC seed, will face the Packers, and the Patriots will face the Broncos. Here, we will discuss the betting lines and odds for these games as well as the rest of the Week 15 slate.

For more info on the league standings, check our latest NFC Championship odds, along with the AFC Championship odds.

NFL Odds for Week 15

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Falcons vs. Buccaneers Odds, Thursday, 8:15 PM EST

• Falcons: Spread +4.0 (-110) | Moneyline +195

• Buccaneers: Spread -4.0 (-110) | Moneyline -240

• Total: Over/Under 44.5 (-110/-110)

Thursday night kicks off Week 15 with the Falcons visiting Tampa Bay under the lights. Both teams need to bounce back after last Sunday.

The Seahawks rolled the Falcons, and the Buccaneers lost outright as 8.5-point favorites. Tampa Bay is in a division race now with the Panthers, so they’re more desperate for a win in this spot. 

Expect the Bucs to lean on home-field energy, knowing their season is now on the line. Baker Mayfield should respond with a massive game. 

Browns vs. Bears Odds, Sunday, 1:00 PM EST

• Browns: Spread +7.5 (-110) | Moneyline +300

• Bears: Spread -7.5 (-110) | Moneyline -380

• Total: Over/Under 39.5 (-110/-110)

The Bears are on the cusp of missing the playoffs after losing to the Packers last week. The Browns, with flashes of upside, will need to play great to take down Chicago. 

Shedeur Sanders has brought a spark to the offense, but it hasn’t translated to consistent wins. The team has struggled this season and is coming off a loss to the Titans. 

As good as Cleveland is on defense, the Bears are a more complete team. Caleb Williams has been fantastic in 2025 in big games, so I’m ready for another monumental performance. 

Ravens vs. Bengals Odds, Sunday, 1:00 PM EST

• Ravens: Spread -2.5 (-110) | Moneyline +195

• Bengals: Spread +2.5 (-110) | Moneyline -240

• Total: Over/Under 51.5 (-110/-110)

The Ravens are clinging to the playoffs by a thread, and they face the worst possible matchup on Sunday given their current style of play. Baltimore can’t score, and they’ll face one of the most explosive offenses in the NFL in the Bengals. 

Cincinnati nearly defeated the Bills last week, but late turnovers from Joe Burrow cost the team. Cincinnati has already beaten Baltimore once this season, and Burrow tends to control the Ravens’ defense.

Chargers vs. Chiefs Odds, Sunday, 1:00 PM EST

• Chargers: Spread +4.5 (-110) | Moneyline +195

• Chiefs: Spread -4.5 (-110) | Moneyline -240

• Total: Over/Under 41.5 (-110/-110)

The Chiefs' playoff hopes are basically dead as of Week 15. They need to win out and have multiple teams ahead of them choke down the final stretch. 

Kansas City can no longer win close games, and it’s the reason they’re going to miss the postseason. They just lost to the Texans and have to face the Chargers, who are superior in 2025. 

Mahomes’ magic may get them a win, but the Chiefs may be too deflated at this point to take at -4.5. 

Bills vs. Patriots Odds, Sunday, 1:00 PM EST

• Bills: Spread -1.0 (-105) | Moneyline -110

• Patriots: Spread +1.0 (-115) | Moneyline -110

• Total: Over/Under 49.5 (-110/-110)

The Patriots can win the AFC East on Sunday by beating the Buffalo Bills. While I expect the Patriots to be victorious in the division, they’re going to have a hard time sweeping the Bills on Sunday. 

Buffalo is one of the best teams in football and is picked to win the AFC. Josh Allen has bailed out the team multiple times this season, and he should have a big game on Sunday. 

As long as Buffalo doesn’t turn the ball over, they’re the easy pick to win on Sunday and get revenge on the Patriots. 

Commanders vs. Giants Odds, Sunday, 1:00 PM EST

• Commanders: Spread +2.0 (-110) | Moneyline +110

• Giants: Spread -2.0 (-110) | Moneyline -130

• Total: Over/Under 47.5 (-110/-110)

The Commanders and Giants are both playing for next season at this point. Even though each of these teams wants to win, it’s probably more beneficial to lose this game and get a higher draft pick. 

The Commanders haven’t been great in any area of the game due to injuries, and the Giants have a young team and no permanent head coach.

New York has the edge with Jaxson Dart and is playing at home.  

Raiders vs. Eagles Odds, Sunday, 1:00 PM EST

• Raiders: Spread +10.5 (-110) | Moneyline +500

• Eagles: Spread -10.5 (-110) | Moneyline -700

• Total: Over/Under 38.5 (-110/-110)

The Philadelphia Eagles’ offense has been stagnant this season. They’re on the verge of collapse, and they’re lucky they play in the NFC East; otherwise, they would have lost their division lead by now. See our NFC East odds and predictions here.

Even though Philadelphia has struggled, they’re playing one of the worst teams in the NFL in Week 15, the Las Vegas Raiders. The Raiders have issues all over the field, and they also have to travel across the country for this game. 

However, Philadelphia is barely scoring two touchdowns per game lately, so asking them to win by 12.5 is a lofty goal. 

Jets vs. Jaguars Odds, Sunday, 1:00 PM EST

• Jets: Spread +12.5 (-110) | Moneyline +525

• Jaguars: Spread -12.5 (-110) | Moneyline -750

• Total: Over/Under 41.5 (-110/-110)

The Jaguars have taken over first place in the AFC South odds after beating the Colts last week. This is the first time in years that we have seen Trevor Lawrence play consistently well. 

Lawrence has thrown for 2,880 yards and 18 touchdowns this season. He has cut down on his interceptions lately as well, which has been a catalyst for the team’s fourth straight win. 

The Jets don’t have a quarterback and are onto 2026, making this game an easy pick. 

Cardinals vs. Texans Odds, Sunday, 1:00 PM EST

• Cardinals: Spread +9.5 (-110) | Moneyline +390

• Texans: Spread -9.5 (-110) | Moneyline -525

• Total: Over/Under 42.5 (-110/-110)

Houston made a statement on Sunday by beating the Kansas City Chiefs on Sunday night. The Texans' offense went stagnant in the second half, but the defense carried the team to a win. 

Arizona was shut down by the Rams' defense in Week 14, and Houston has an even better unit than Los Angeles. The Texans should torment Jacoby Brissett at quarterback, leading to another win and their march to the playoffs. 

Packers vs. Broncos Odds, Sunday, 4:25 PM EST

• Packers: Spread -2.5 (-110) | Moneyline -140

• Broncos: Spread +2.5 (-110) | Moneyline +120

• Total: Over/Under 43.5 (-110/-110)

If the Broncos want to claim the top seed in the AFC, they have to beat Green Bay on Sunday. The Patriots and Broncos have identical records, so if Denver loses a game, it may lose control of the AFC race. 

Green Bay won and covered against the Bears last week. Green Bay has always had a dominant defense, but it has thrived with offense lately. 

Jordan Love is a road underdog, which is challenging, but the Packers have a slight edge on offense in this game. I expect this to make the ultimate difference. 

Lions vs. Rams Odds, Sunday, 4:25 PM EST

• Lions: Spread +5.5 (-110) | Moneyline +225

• Rams: Spread -5.5 (-110) | Moneyline -275

• Total: Over/Under 55.0 (-110/-110)

The game of the week features the Lions and Rams. Detroit will likely rely on its balanced offense and capitalize on Los Angeles' defensive lapses. 

The Rams have been dominant at home, which gives them an edge. They have the most explosive offense in the league and are the current Super Bowl favorites.  

The Lions can score, but I’m concerned about their defense. If Los Angeles prevails, they can most likely keep Detroit out of the playoffs, which is enough motivation for a big game from Matthew Stafford.

Panthers vs. Saints Odds, Sunday, 4:25 PM EST

• Panthers: Spread -2.5 (-110) | Moneyline -155

• Saints: Spread +2.5 (-110) | Moneyline +130

• Total: Over/Under 40.5 (-110/-110)

Can the Saints upset two NFC South giants in a row? Last week, New Orleans beat Tampa Bay as an 8.5-point dog on the road. Now, they get the Panthers at home, who are vying for a division title. 

The Panthers are just a 2.5-point road favorite here, and this line has a lot of value. Carolina is better than New Orleans, and they also have a very clutch quarterback in Bryce Young. 

If the Panthers win the remainder of their games, they’ll hoist the NFC South crown. This should be enough motivation for them to shine on Sunday. See our NFC South odds and predictions.

Titans vs. 49ers Odds, Sunday, 4:25 PM EST

• Titans: Spread +12.5 (-110) | Moneyline +575

• 49ers: Spread -12.5 (-110) | Moneyline -850

• Total: Over/Under 44.5 (-110/-110)

The Titans upset the Browns on Sunday, which is remarkable considering Tennessee isn’t a very good team. However, they face a much more formidable challenge this week as a 12.5-point road underdog against the 49ers. 

San Francisco had a bye in Week 14, so they’ll come into this game rested. San Francisco is fighting for a playoff position, and they should come out fast after getting rested the past week. 

Colts vs. Seahawks Odds, Sunday, 4:25 PM EST

• Colts: Spread +13.5 (-110) | Moneyline +575

• Seahawks: Spread -13.5 (-110) | Moneyline -850

• Total: Over/Under 42.5 (-110/-110)

The Indianapolis Colts were one of the best teams in the AFC at the beginning of the season. Yet, this narrative has faded drastically, and the team is down bad heading into Week 16 of the season.

The Colts lost their quarterback, Daniel Jones, to a torn Achilles last week. Their backup, Anthony Richardson, is also on the IR, so rookie quarterback Riley Leonard will make his first start. 

Leonard isn’t ready to start in the NFL, and for this reason, I’ll lay the points with Seattle. 

Vikings vs. Cowboys Odds, Sunday, 8:20 PM EST

• Vikings: Spread +5.5 (-110) | Moneyline +220

• Cowboys: Spread -5.5 (-110) | Moneyline -270

• Total: Over/Under 47.5 (-110/-110)

The Vikings smacked the Commanders last week in JJ McCarthy’s return to the lineup. McCarthy completed 16 of 23 passes for 163 yards and three touchdowns. 

The quarterback hasn’t been great this season, but he did pick up a win in prime time earlier in the year. He should succeed against the Cowboys' defense because they allow a lot of yards and points. 

If McCarthy can limit his turnovers, there is no reason Minnesota won’t be competitive in this contest. 

Dolphins vs. Steelers Odds, Monday, 8:15 PM EST

• Dolphins: Spread +3.5 (-115) | Moneyline +155

• Steelers: Spread -3.5 (-105) | Moneyline -185

• Total: Over/Under 41.5 (-110/-110)

The Miami Dolphins have been hot lately after a tough start to the season. They’re not out of the playoff conversation if they can win the remainder of their games. 

The Steelers are coming off a blowout win over the Ravens. The scoreboard looked more competitive than the game, as Pittsburgh asserted its will on Baltimore for four quarters. 

The Dolphins’ most significant issue in this game is that they don’t play well in the cold. The temperatures in Pittsburgh are expected to be freezing on Monday night.

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