NFL Week 5 Odds: Betting Lines for Every Game

• The Eagles and Bills are the only unbeaten teams in the NFL 

• Lamar Jackson is now 1-5 against the Chiefs after last Sunday’s loss 

• The Vikings will play in their second consecutive international game on Sunday 

The Philadelphia Eagles and Buffalo Bills advanced to 4-0 on Sunday to become the only unbeaten teams in the NFL. While these teams are thriving, the Ravens and Texans are falling apart through four games. 

One of these teams will be 1-4 following their game in Week 5 matchup in Baltimore. The Ravens are expected to win, but they have one of the worst defenses in the NFL. 

This game, along with a few others, will continue to shape our Super Bowl opinions. Here, we will give a short analysis of each game on the slate with our pick. 

NFL Odds for Week 5

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49ers vs. Rams Odds, Thursday, 8:20 PM EST

• 49ers: Spread +5.5 (-110) | Moneyline +210

• Rams: Spread -5.5 (-110) | Moneyline -260

• Total: Over/Under 47.5 (-105/-115)

Thursday will be the second consecutive week with an NFC West showdown on Prime. The San Francisco 49ers lost to the Jacksonville Jaguars last Sunday. 

The team had multiple chances to steal the victory, but they couldn’t capitalize. Brock Purdy had a late fumble on a potential game-winning drive, and the 49ers never touched the ball again. 

The Rams beat the Colts at home as Matthew Stafford continued to light up the stat sheet. The quarterback threw for 275 yards with three touchdowns against Indianapolis in a seven-point victory. 

Los Angeles’ passing game will be too much for the depleted 49ers' defense on a short week. 

Vikings vs. Browns Odds, Sunday, 9:30 PM EST

• Vikings: Spread +3.5 (-110) | Moneyline -200

• Browns: Spread -3.5 (-110) | Moneyline +165

• Total: Over/Under 36.5 (-110/-110)

The Minnesota Vikings lost to the Pittsburgh Steelers in Week 4, 24-21. The team wasn’t as sharp as they usually are defensively, which ultimately cost them the game. 

Despite the poor performance in Week 4, we’re expecting a rebound on Sunday. This week is Minnesota’s second consecutive international game, so they’ve adjusted to being overseas. 

Cleveland will travel across the pond this week, and this gives Minnesota an edge. Even though the Vikings are a better team, the spread is very appealing for the Browns because of the hook. 

Texans vs. Ravens Odds, Sunday, 1:00 PM EST

• Texans: Spread +3.5 (-115) | Moneyline +140

• Ravens: Spread -3.5 (-105) | Moneyline -165

• Total: Over/Under 43.5 (-110/-110)

The Houston Texans and Minnesota Vikings are both desperate for a win on Sunday. Each team is 1-3, and another loss through five weeks will be detrimental to their playoff chances. 

The Ravens are very injured on defense, and it has shown in the stats. They have the second-worst passing defense in the NFL, and the offense needs to help pick the team up through this tough time. 

Despite this, Lamar Jackson hasn’t looked like an NFL MVP and this must change for Baltimore to get back in the AFC Championship conversation. We don’t expect a perfect performance from Baltimore on Sunday, but they’re a touchdown favorite for a reason. 

Giants vs. Saints Odds, Sunday, 1:00 PM EST

• Giants: Spread +1.0 (-110) | Moneyline -105

• Saints: Spread -1.0 (-110) | Moneyline -115

• Total: Over/Under 40.5 (-110/-110)

Jaxson Dart has taken over New York and he has a chance to go 2-0 as a starter. Dart electrified the Giants faithful, going 13 of 20 for 111 yards with one touchdown through the air against the Chargers. 

The quarterback also carried the ball 10 times for 54 yards and had a rushing touchdown. New York upset the Chargers, but now the rookie quarterback has to make his first road start against the Saints. 

New Orleans isn’t a great football team, but the Superdome is a very difficult environment. Both teams need a win, but Malik Nabers' injury will make the difference. 

Dolphins vs. Panthers Odds, Sunday, 1:00 PM EST

• Dolphins: Spread +1.0 (-115) | Moneyline +100

• Panthers: Spread -1.0 (-105) | Moneyline -120

• Total: Over/Under 44.5 (-115/-105)

The Dolphins and Panthers are both bad football teams, but Miami has a lot more talent. The Dolphins' defense hasn’t been efficient, and the offense has a turnover issue, but their team speed is legitimate. 

Between Tyreek Hill, De’Von Achane, and Jaylen Waddle, Miami should have an offensive explosion against the Panthers. 

Carolina had a strong start against the Patriots, but New England poured on the points. Miami has a better offense than New England, and we don’t expect the Panthers to keep up with their tempo on Sunday. 

Raiders vs. Colts Odds, Sunday, 1:00 PM EST

• Raiders: Spread +6.5 (-110) | Moneyline +250

• Colts: Spread -6.5 (-110) | Moneyline -310

• Total: Over/Under 43.5 (-110/-110)

The Las Vegas Raiders dropped a tight game to the Bears on Sunday at home. The Raiders have lost three straight games since their win to open the season against the Patriots. 

The Indianapolis Colts suffered their first loss of the season on Sunday against the Rams. Tutu Atwell caught a game winning 88 yard touchdown pass on a blown coverage by the Colts. 

Despite the loss, Indianapolis is 3-1 and Daniel Jones has been fantastic all season. The quarterback is third in passing yards this season with 1078, and he should have a big day against Las Vegas. 

Broncos vs. Eagles Odds, Sunday, 1:00 PM EST

• Broncos: Spread +4.5 (-110) | Moneyline +180

• Eagles: Spread -4.5 (-110) | Moneyline -220

• Total: Over/Under 43.5 (-110/-110)

The Philadelphia Eagles advanced to 4-0 after an 8-point win in Tampa Bay. The Eagles faded in the second half, but their defense still made plays in high-leverage situations. 

Philadelphia knows how to win, but they have locker room drama once again. After the game, AJ Brown tweeted a screenshot that stated, “If you’re not welcomed, not listened to, quietly withdraw. Don’t make a scene. Shrug your shoulders and be on your way.” 

The Eagles' locker room issues could be a problem. We’re expecting the Broncos defense to lead the team to a road cover against the defending champs. 

Cowboys vs. Jets Odds, Sunday, 1:00 PM EST

• Cowboys: Spread -2.5 (-120) | Moneyline -150

• Jets: Spread +2.5 (+100) | Moneyline +125

• Total: Over/Under 46.5 (-115/-105)

The Dallas Cowboys have a horrendous defense, but they lit up the Green Bay Packers in Week 4 offensively. Dak Prescott threw for 319 yards and three touchdowns in a 40-40 tie. 

The Cowboys don’t have Ceedee Lamb, but George Pickens looks like a certified star at wide receiver. Dallas’ offense is talented enough to carry this team against average opponents. 

The New York Jets are the definition of an average opponent. The Jets should be able to score against the Cowboys because everyone has been able to in 2025, but Dallas will prevail in a shootout. 

Titans vs. Cardinals Odds, Sunday, 4:05 PM EST

• Titans: Spread +8.5 (-110) | Moneyline +375

• Cardinals: Spread -8.5 (-110) | Moneyline -500

• Total: Over/Under 41.5 (-110/-110)

Cam Ward said he played like “ass” to the media following the Titans' loss to the Texans in Week 4. Ward’s NFL career is off to a rough start, which is no surprise for a rookie. 

Ward will improve, but he has a tall task against the Cardinals on Sunday. Arizona is coming off a three-point loss to the Saints, where they climbed back into the game, but still fell short. 

This is a great get-right spot for Arizona against an inferior opponent. Kyler Murray and Trey McBride should connect multiple times in a dominant win. 

Buccaneers vs. Seahawks Odds, Sunday, 4:05 PM EST

• Buccaneers: Spread +3.5 (-110) | Moneyline +155

• Seahawks: Spread -3.5 (-110) | Moneyline -185

• Total: Over/Under 44.5 (-110/-110)

The Tampa Bay Buccaneers started very slow against the Eagles on Sunday, but battled back to lose by just six points. Tampa Bay had two chances to tie the game down the stretch, but failed on both occasions. 

The Buccaneers are a short underdog on the road, but we believe they’re the better team. Baker Mayfield has been elite in the fourth quarter, and Bucky Irving is one of the brightest stars in the game. 

Commanders vs. Chargers Odds, Sunday, 4:25 PM EST

• Commanders: Spread +2.5 (+100) | Moneyline +125

• Chargers: Spread -2.5 (-120) | Moneyline -150

• Total: Over/Under 47.5 (-110/-110)

The Los Angeles Chargers need to respond following their loss to the Giants on Sunday. Los Angeles got beat by a rookie quarterback making his first start in Jaxson Dart. 

The Chargers were expected to take control of the AFC West, but the Chiefs are right back in the mix after four weeks. The Commanders will likely get Jayden Daniels back in the lineup, which will help their cause. 

Daniels wonthe NFL Offensive Rookie of the Year in 2024, but he should be shaky coming off his injury. 

Lions vs. Bengals Odds, Sunday, 4:25 PM EST

• Lions: Spread -9.5 (-115) | Moneyline -450

• Bengals: Spread +9.5 (-105) | Moneyline +350

• Total: Over/Under 49.5 (-105/-115)

Jake Browning is a reliable backup, but the drop-off between him and Joe Burrow is drastic. The Bengals don’t function as well without their starting quarterback, and Detroit will be a major challenge. 

The Lions can score at will, and the Bengals don’t have this same level of explosion. Additionally, Detroit has a better defense, so this game should easily go in favor of the defending NFC North champions. 

Patriots vs. Bills Odds, Sunday, 8:20 PM EST

• Patriots: Spread +7.5 (-110) | Moneyline +320

• Bills: Spread -7.5 (-110) | Moneyline -400

• Total: Over/Under 49.5 (-110/-110)

The top two teams in the AFC East will battle on Sunday when the Bills host the Patriots. Buffalo is favored to win the Super Bowl, and a big reason for this is Josh Allen.

Allen is the MVP favorite, and he has been fantastic in 2025. The quarterback has thrown for 964 yards with seven touchdowns this season. 

The Patriots are on the rise, but they’re not on the same level as the Bills. Buffalo should cover because of a big second half on Sunday. 

Chiefs vs. Jaguars Odds, Monday, 8:15 PM EST

• Chiefs: Spread -3.5 (-105) | Moneyline -185

• Jaguars: Spread +3.5 (-115) | Moneyline +155

• Total: Over/Under 45.5 (-110/-110)

The Kansas City Chiefs are back after their win over the Ravens. The Chiefs dominated Baltimore and silenced Lamar Jackson throughout the game. 

Kansas City lacked speed in the first few weeks of the season because they didn’t have Xavier Worthy. Worthy suffered a shoulder injury in Week 1, but returned against Baltimore and had one of the biggest weeks of his career. 

The Jaguars are 3-1 and leading the AFC South, but they're a step below the Chiefs.

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