AFC East Odds, Predictions, Betting Picks 2025/26: Backing the Bills Once Again in 2025

• Khalil Shakir and Keon Coleman are expected to be the Bills’ top two receivers

• Joey Bosa played 14 games for the Chargers last season

• The Patriots are projected to start two rookies on their offensive line

The Buffalo Bills seem to be set up for an easy path to win their sixth consecutive AFC East title this season. They bring back most of their core, and added some key new weapons to help end the team’s Super Bowl drought. While the New England Patriots are turning some heads this summer, do they have enough to compete with a proven winner like Buffalo?

Below, we will share the latest insights into all four AFC East squads and our pick to win.

AFC East Odds

Odds taken from BetMGM Sportsbook. Sign up for a BetMGM account with our promo code WSNSPORTS and claim the bonus: Get Up to $1,500 in Bonus Bets*

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AFC East Predictions

The Bills enter as an overwhelming favorite to repeat as AFC East champions this season, but we still have two major questions heading into the season. The first involves the growth of the team’s young receiving corps. The top two receivers are expected to be 25-year-old Khalil Shakir and 22-year-old Keon Coleman. Both have turned some heads in Buffalo, but they have yet to show they have what it takes to be a number-one receiver in the NFL.

The other question we have bout Buffalo is Joey Bosa. The former Chargers superstar was limited to 14 games between the 2022 and 2023 seasons due to injury. While he played 14 games last season, he only finished with five sacks and 17 tackles. That is nowhere close to the production Bosa had delivered up until 2021, and has us wondering how much the 30-year-old has left in the tank. 

There is a lot of excitement around Drake Maye and the New England Patriots, as BetMGM’s odds indicate. However, there remain major concerns about the offensive line. As of now, a pair of rookies are projected to start in fourth-overall pick Will Campbell and third-round selection Jared Wilson. While the latter has looked fantastic in camp, the former has not looked ready for the NFL level. 

The most surprising change in the odds to win the AFC East involved the Miami Dolphins, who fell behind the Pats. The team has been loaded with talent, but injuries have cost them any chance at a Super Bowl. The injuries are already starting to add up in camps, making fans nervous heading into the pre-season. Combine that with Tyreek Hill’s regressions and issues with the team, and you can see why BetMGM doesn’t view them as true contenders.

The New York Jets remain well behind the rest of the division. Justin Fields replacing Aaron Rodgers may help spark the locker room, but it won’t be enough to lead this team to finish about .500 this season.

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AFC East Winner Pick

Buffalo Bills (-325) at BetMGM Sportsbook

This is one of the easiest divisions to pick heading into the 2025 season. They are far from perfect, but still have far more proven talent than their three AFC East rivals. While the Pats could make this race close, it would take several key injuries for them to overtake a great Bills team.

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How to Bet on the AFC East

Betting on the AFC East is easy, but learning where to find and place these bets can take time. If you find yourself stuck, we have you covered. 

Here is an easy step-by-step guide to help you get started:

1. Choose the sportsbook you want to wager with

2. Select “Football” or “NFL” from the betting catalog, usually found on the top or side menu

3. Click on the tab for “Futures”

4. Read through the options for the “Division Winner” section

5. Scroll down until you find the AFC East

6. Select the team you think will win

7. Navigate to your betslip to enter how much you want to wager

8. Hit submit, and you are all set!

All division futures bets will be paid out once the season ends and a champion is officially crowned. 

How to Read AFC East Odds

NFL futures odds work the same as any other bet. Each bet includes a number following the team or player, preceded by a plus or minus sign. 

A plus sign before the number usually indicates an underdog, which is common with futures bets. If the odds next to a team or player have a plus sign, that is the amount that you will win for every $100 you bet.

A minus sign usually indicates the favorite to win, though they are rarely seen for future bets. A minus sign in front of the odds means that is how much you need to bet to win $100.

For example, you bet $100 on the Patriots at +600 to win the AFC East. If they win the division, you will win $600. 

If you aren't looking to bet $100 at a time, don't worry! Check out our odds calculator to help you determine potential winnings based on different wager amounts.

Where to Bet on the AFC East

Are you ready to start betting on the AFC East but unsure where to start? If so, we have you covered with our sportsbook reviews. Here are our three favorite sportsbooks we use when betting on NFL futures:

• BetRivers Sportsbook: This sportsbook has been one of the few success stories from mid-size operators in the US. The platform isn’t as sharp as FanDuel or BetMGM, but it offers bettors some fantastic bonuses and very competitive odds. If you are looking for a smaller and more player-friendly platform, we highly recommend BetRivers. Claim the welcome offer today: $500 Bonus Bet.

• FanDuel Sportsbook: If you are betting on America’s favorite sport, why not use its favorite sportsbook? FanDuel offers bettors an easy-to-use platform that is easy to navigate. The odds, promotions, and rewards are unmatched, meaning you can have more money in your pocket when you win. Click our link and claim the bonus offer: Bet $5, Get $300 in Bonus Bets if Your Bet Wins.

• BetMGMSportsbook: BetMGM has established itself as one of the top sportsbooks in the US. The platform captures the Las Vegas feel and allows players to bet on games easily. Be sure to pay attention to their fantastic loyalty program, which can lead to some big rewards. Use our code WSNSPORTS and claim your bonus today: Get Up to $1,500 in Bonus Bets*.

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AFC East Winner History

The Bills won their fifth consecutive AFC East title in 2024. They have dominated the division since the fall of the Patriots, the only other team to win a division title in the last decade.

Below are the last ten teams to win the AFC East.