NFC West Odds, Predictions, Betting Picks 2025/26: Expect the 49ers to Bounce Back in a Big Way

• The San Francisco 49ers are listed as the betting favorite to win the NFC West division title

• Star running back Christian McCaffrey is expected to be fully healthy heading into the year 

• The Los Angeles Rams defense finished last season ranked 20th in Def DVOA and 22nd in EPA

After being ravaged by injuries last year, the San Francisco 49ers look to reclaim the division title now that they are at full health. Even with health back on their side, oddsmakers have tempered their expectations as the Los Angeles Rams enter the season as the betting favorite to win the NFC West. Should their additions pan out, then expect a close race until the very end.

NFC West Winner Odds

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NFC West Winner Predictions

Once listed as the betting favorite to win the NFC West division title earlier in the preseason, the Los Angeles Rams have stumbled down the oddsboard as question marks loom over their offense after it was reported Matthew Stafford is dealing with an injury. Their defense will also need to drastically elevate their level of play should they want to retain their title as that side of the field finished last season ranked 20th overall in Def DVOA and 22nd in Def EPA.

Speaking of struggling defenses, the Arizona Cardinals will also need to find more success this season as they finished the year ranked 19th overall in Def Pass DVOA and 18th in Def Rush DVOA. Kyler Murray will also need to show he can stay healthy for the full length of the season as their production on offense takes a nose dive when he has to miss some time. Even at their inflated odds, pass on the Cardinals to win the division title.

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NFC West Winner - My Pick

San Francisco 49ers (+155) at FanDuel Sportsbook

With health back on their side, the San Francisco 49ers offense are projected to be one of the best units in the league as they field an abundance of talent at every skill position. Especially if Christian McCaffrey is able to round back into Offensive Player of the Year award winning form after injuries forced him to sit out a majority of the 2024 season. Should their defense give them the production they need to be a well rounded unit, then expect the 49ers to win the NFC West.

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How to Bet on the NFC West Winner

When betting on a team to win their division, it’s important to factor in their continuity on both sides of the ball. A team who brings in a majority of their players are in a great position to succeed as it helps limit the amount of variance in their contests. Signing productive players throughout the offseason is also vital as it gives you the depth needed to deal with injuries that are sustained during the year to help remain competitive for the duration of the season.

A team’s strength of schedule and situational sports are also very important to consider as an easier schedule drastically increases a team’s chances of finishing in first in their respective division standings. Look to back a team who receives plenty of rest between primetime games and international travel as it reduces the chances of them suffering a devastating injury.

How to Read NFC West Winner Odds

Before placing a wager on a team to win the NFC West, it’s vital to know how the listed odds work. If you bet on the San Francisco 49ers to win the division at their preseason odds of +175, then a $100 wager would profit you $175 if they win the NFC West.

If you wait to see if they get off to a hot start and are listed with a minus sign in front of their odds (-125 for example), then you would need to wager $125 to profit $100. Make sure you line shop before placing a wager as the odds for the same market can vary between each sportsbook.

Where to Bet on the NFC West Winner

FanDuel Sportsbook is one of the top choices to use for the NFL as they consistently roll out amazing promotions for their users to use and are quick to update their odds throughout the season. If you have not signed up yet with FanDuel Sportsbook and are looking to get in on the action, you can claim the following offer: Bet $5, Get $300 in Bonus Bets if Your Bet Wins.

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NFC West Winner History

After dominating the NFC West early in its inception, the San Francisco 49ers and Los Angeles Rams are expected to be in a two horse race for the division title this season. Both teams reside at the top in regard to most division titles as the 49ers currently lead the NFC West with 22 championships while the Rams are in second with 15. The Seattle Seahawks meanwhile are in third with nine while the Arizona Cardinals are in last place with three.