NFC West Odds, Predictions, Betting Picks 2025/26: San Francisco’s Division Hopes Rest on Brock Purdy

• The San Francisco 49ers odds to win the NFC West division title continues to grow

• San Francisco’s Brock Purdy is expected to return from injury in either week four or five

• The Arizona Cardinals offensive line ranks near the top of the board in Pass Protection Win Rate

After being ravaged by injuries last year, the San Francisco 49ers look to reclaim the division title now that they are at full health. Even with health back on their side, oddsmakers have tempered their expectations as the Los Angeles Rams enter the season as the betting favorite to win the NFC West. Should their additions pan out, then expect a close race until the very end.

NFC West Winner Odds

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NFC West Winner Predictions

After losing to Philadelphia in week three, the Los Angeles Rams are now playing from behind as they are currently one game back from San Francisco for first in the NFC West standings. Matthew Stafford was uncharacteristically inaccurate in their loss as he finished the contest completing just 57% of his throws. Should Brock Purdy struggle to round back into form when he returns from injury, then expect the Rams to remain in contention for the division title.

As for Arizona, the Cardinals look far more competitive on offense this season after struggling last year as they currently rank top-15 in Off EPA. Their offensive line has played a major role in their resurgence as their front five ranks above league average in Pass Protection Win Rate and in PFF Grade. Should their defense continue to give them the production they need to be a well rounded unit, then they may be worth a wager to win the division at their long odds.

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NFC West Winner - My Pick

San Francisco 49ers (-105) at FanDuel Sportsbook

Even though the San Francisco 49ers managed to secure the win over the Arizona Cardinals, it was anything but pretty as Mac Jones struggled to sustain drives down the field. The difference in their level of play is noticeable as Purdy ranks top-3 in Quarterback EPA per play while Jones ranks near dead last in PFF Grade. With Purdy expected to make his return in week four or five, bet the 49ers to win the division title now before they round back into dominant form.

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How to Bet on the NFC West Winner

When betting on a team to win their division, it’s important to factor in their continuity on both sides of the ball. A team who brings in a majority of their players are in a great position to succeed as it helps limit the amount of variance in their contests. Signing productive players throughout the offseason is also vital as it gives you the depth needed to deal with injuries that are sustained during the year to help remain competitive for the duration of the season.

A team’s strength of schedule and situational sports are also very important to consider as an easier schedule drastically increases a team’s chances of finishing in first in their respective division standings. Look to back a team who receives plenty of rest between primetime games and international travel as it reduces the chances of them suffering a devastating injury.

How to Read NFC West Winner Odds

Before placing a wager on a team to win the NFC West, it’s vital to know how the listed odds work. If you bet on the San Francisco 49ers to win the division at their preseason odds of +175, then a $100 wager would profit you $175 if they win the NFC West.

If you wait to see if they get off to a hot start and are listed with a minus sign in front of their odds (-125 for example), then you would need to wager $125 to profit $100. Make sure you line shop before placing a wager as the odds for the same market can vary between each sportsbook.

Where to Bet on the NFC West Winner

FanDuel Sportsbook is one of the top choices to use for the NFL as they consistently roll out amazing promotions for their users to use and are quick to update their odds throughout the season. If you have not signed up yet with FanDuel Sportsbook and are looking to get in on the action, you can claim the following offer: Bet $5, Get $300 in Bonus Bets if Your Bet Wins.

BetMGM Sportsbook is also another great app to use as they offer a wide range of markets and are very competitive with their pricing. New users can also receive welcome offer: Bet $10, Get $150 if You Win* after creating an account with the WSN promo code WSNSPORTS.

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NFC West Winner History

After dominating the NFC West early in its inception, the San Francisco 49ers and Los Angeles Rams are expected to be in a two horse race for the division title this season. Both teams reside at the top in regard to most division titles as the 49ers currently lead the NFC West with 22 championships while the Rams are in second with 15. The Seattle Seahawks meanwhile are in third with nine while the Arizona Cardinals are in last place with three.