NFL Thanksgiving Day Odds, Predictions, Best Picks

Thanksgiving Day is the most anticipated betting day of the NFL regular season, featuring three high-stakes matchups with significant playoff implications. Using the latest odds from FanDuel Sportsbook, here is a breakdown of the three-game slate, including our analysis and best bets for a profitable holiday.

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Thanksgiving Day Odds - The Thanksgiving Tripleheader

1. Green Bay Packers at Detroit Lions (1:00 PM ET)

The traditional Thanksgiving opener features an intense NFC North rematch. While the Lions are the clear division favorite and benefit from home-field advantage, they were convincingly beaten by the Packers earlier in the season.

Historically, Detroit has struggled to cover the spread on Thanksgiving. This line suggests a tight, physical contest, but the Lions' explosive running game presents a major challenge for the Packers' run defense. Given the historical volatility of this early game, backing the underdog is often a smart play.

2. Kansas City Chiefs at Dallas Cowboys (4:30 PM ET)

The marquee matchup of the day pits two of the NFL's biggest draws in a potential shootout.

The Chiefs are the road favorite, but teams coming off an overtime game, as the Chiefs are, have historically struggled to cover the spread on short rest. However, this total is set high for a reason: both offenses are loaded with star power (Mahomes, Kelce, Prescott, Lamb) and the focus will be on the passing game. The Cowboys, despite their struggles against the spread on Thanksgiving, will embrace the high-scoring nature of this contest at home.

3. Cincinnati Bengals at Baltimore Ravens (8:20 PM ET)

The Thanksgiving nightcap is a critical AFC North divisional clash, often marked by massive playoff implications.

The Ravens enter as heavy favorites, riding the momentum of their elite defense and strong home-field performance. Historically, favorites in the primetime Thanksgiving game have dominated, covering the spread nearly 78% of the time since the third game was added in 2006.

While the Bengals are always a threat in this rivalry, the Ravens' stout defense and the historical trend make the home favorite the safest bet.

How to Bet on NFL Thanksgiving Games

Thanksgiving Day is an excellent time for beginners to try sports betting, as the three high-profile games make the options straightforward.

For more on NFL betting, take a look also at the best NFL betting sites and the best NFL football promo codes to get you started.

1. Moneyline (ML)

This is the simplest bet. You are betting solely on which team will win the game outright.

• Favorite (-): Has lower payout potential but a higher probability of winning (e.g., Ravens -370). You must bet $370 to win $100.

• Underdog (+): Has higher payout potential but a lower probability of winning (e.g., Bengals +295). A $100 bet wins $295.

2. Point Spread (ATS)

The spread attempts to level the playing field. The favorite must win by more than the spread number, while the underdog can lose by less than the spread number or win outright.

• Chiefs -3.0: The Chiefs must win by 4 points or more.

• Cowboys +3.0: The Cowboys must win, or lose by 1 or 2 points. If the Chiefs win by exactly 3, it is a "push" and the bet is refunded.

3. Game Totals (Over/Under)

You are betting whether the total combined points scored by both teams will be Over or Under the number set by the sportsbook (e.g., 51.5).

4. Player Props

These bets focus on individual player performance, such as:

• Patrick Mahomes Over/Under 285.5 Passing Yards

• Jahmyr Gibbs Anytime Touchdown Scorer

• Micah Parsons Over 0.75 Sacks

5. Same Game Parlays (SGP)

This is a popular, high-risk, high-reward bet that allows you to combine multiple wagers from a single game into one large bet. For the SGP to win, every single selection (or "leg") must hit.

• Example (Chiefs vs. Cowboys): Combine Chiefs Moneyline + Patrick Mahomes Over 2.5 Passing TDs + CeeDee Lamb Over 75.5 Receiving Yards.

• Benefit: SGPs offer massive payouts because the odds multiply, but they are difficult to win, making them a fun option for the Thanksgiving nightcap.

The three primary Thanksgiving games offer excellent opportunities for all these betting types.