NFL Week 1 Odds: Football Is Back

• The Eagles open the season against the Cowboys 

• The Chiefs and Chargers battle on Friday

• There are 13 games on Sunday 

The Philadelphia Eagles will kick off the season on Thursday at Lincoln Financial Field against the Dallas Cowboys. While we don’t anticipate any upset here, there are plenty of games where we expect underdogs to rise to the occasion.

The quest for the Super Bowl begins in Week 1. Here, we will give a short analysis of each game on the slate with our pick.

NFL Odds for Week 1

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Cowboys vs. Eagles Odds, Thursday, 8:20 PM EST

Cowboys: Spread +8.0 (-110), Moneyline +328

Eagles: Spread -8.0 (-110), Moneyline -430

Total: Over/under 47.5 (-110/-110)

The Philadelphia Eagles will unveil their Super Bowl banner on Thursday night, and the Cowboys will look to destroy the party. Dallas just traded Micah Parsons, and are in no position to compete with the Eagles in the NFC East. 

Dallas has been plagued by Jerry Jones for years, and it’s starting to hurt them very badly. Jalen Hurts and Saquon Barkley just need to be average in this game, and it should lead to an easy cover. 

For more info, read our full Cowboys vs Eagles prediction.

• Best Bet: Eagles -8.0 (-110) at Caesars

Chiefs vs. Chargers Odds, Friday, 8:00 PM EST

Chiefs: Spread -3.0 (-115), Moneyline -170

Chargers: Spread +8.0 (-105), Eagles +143

Total: Over/under 47.5 (-110/-110)

The Los Angeles Chargers are expected to contend with the Kansas City Chiefs for the AFC West crown. The Chargers can establish the ground game and give the Chiefs a lot of issues in the opener. 

However, any team with Patrick Mahomes can overcome adversity. We’ll take the Chiefs to rebound after a poor conclusion to the 2024 season.

Get more betting insights with our Chiefs vs Chargers prediction.

• Best Bet: Chiefs -3.0 (-115) at Caesars

Dolphins vs. Colts Odds, Sunday, 1:00 PM EST

Dolphins: Spread 1.5 (-118), Moneyline -102

Colts: Spread -1.5 (-104), Moneyline -116

Total: Over/under 47.0 (-110/-110)

It’s rare to get a second chance in the NFL, but this is the case for Daniel Jones. Jones isn’t regarded as an elite quarterback, but he has a lot of talent around him in Indianapolis. 

Yet, we trust Mike McDaniel’s offense more in Week 1 because of their experience as a group. Tua Tagovailoa is still a legitimate starting quarterback in the NFL and tends to play well inside domes. 

• Best Bet: Dolphins +1.5 (-118) at Caesars

Raiders vs. Patriots Odds, Sunday, 1:00 PM EST

Raiders: Spread +2.5 (+100), Moneyline +122

Patriots: Spread -2.5 (-120), Moneyline -145

Total: Over/under 43.5 (-110/-110)

The Patriots have high expectations, but they’re not an elite team. There are plenty of holes throughout the group, but we don’t have much concern with the defense. 

New England’s defense has kept them in games for years despite bad records. The offense has improved, so the Patriots should start hot against Pete Caroll’s Raiders. 

Drake Maye had turnover issues last season, so look for this to be the deciding factor in the game. 

• Best Bet: Patriots -2.5 (-120) at Caesars

Steelers vs. Jets Odds, Sunday, 1:00 PM EST

Steelers: Spread -2.5 (-120), Moneyline -155

Jets: Spread +2.5 (+100), Moneyline +130

Total: Over/under 38.5 (-110/-110)

Justin Fields has freakish athletic ability, but he isn’t a complete NFL quarterback. On the other hand, Aaron Rodgers is past his prime, so both quarterbacks could struggle on Sunday.

Yet, the Steelers are consistent winners, while Aaron Glenn is making his head coaching debut for New York. There are too many moving pieces for New York to overcome in Week 1. 

This game may be close for a while, but Pittsburgh is prepared for the second half, where the same can’t be said about New York. 

• Best Bet: Steelers -2.5 (-120) at Caesars

Cardinals vs. Saints Odds, Sunday, 1:00 PM EST

Cardinals: Spread -6.5 (-110), Moneyline -285

Saints: Spread +6.5 (-110), Moneyline +228

Total: Over/under 43.5 (-110/-110)

Spencer Rattler isn’t worthy of being a starting quarterback in the NFL. Thanks to poor drafting, the Saints will line up Rattler under center in Week 1. 

The Cardinals aren’t a playoff team, but they’re much better than New Orleans. Kyler Murray will be tough for New Orleans defense to stop. 

• Best Bet: Cardinals -6.5 (-110) at Caesars

Bengals vs. Browns Odds, Sunday, 1:00 PM EST

Bengals: Spread -5.5 (-115), Moneyline -250

Browns: Spread +5.5 (-105), Moneyline +205

Total: Over/under 47.5 (-110/-110)

Division games are usually close, but the Bengals' offense will be too much for the Browns in this spot. Cleveland’s defense with Myles Garrett should keep them in the game to a point, but Joe Burrow and company will overpower the unit by the fourth quarter. 

Cleveland is expected to be one of the worst teams in the NFL this season. They don’t have many impact players on offense, and it’s hard to beat a team like the Bengals without firepower. 

• Best Bet: Bengals -5.5 (-115) at Caesars

Giants vs. Commanders Odds, Sunday, 1:00 PM EST

Giants: Spread -6.0 (-110), Moneyline +215

Commanders: Spread +6.0 (-110), Moneyline -267

Total: Over/under 45.5 (-110/-110)

The Washington Commanders are a much better team than the New York Giants, but Brian Daboll’s squad has the talent to keep this game close. Washington consistently found themselves in close games, and they’re facing an improved Giants team on Sunday. 

Russell Wilson’s composure and some big plays to Malik Nabers gives New York a chance to win. The Giants are being doubted in this spot, but Washington was known for being in close games in the fourth quarter in 2024, so six points are too good to resist. 

• Best Bet: Giants +6.0 (-110) at Caesars

Buccaneers vs. Falcons Odds, Sunday, 1:00 PM EST

Buccaneers: Spread -2.5 (-110), Moneyline -140

Falcons: Spread +2.5 (-110), Moneyline +118

Total: Over/under 47.5 (-110/-110)

The Atlanta Falcons should give the Tampa Bay Buccaneers some competition in the NFC South. The Falcons' depth just can’t compete with the Buccaneers in Week 1. 

Bucky Irving and Rachaad White is a great backfield combination, and Baker Mayfield has been fantastic at quarterback since arriving in Tampa Bay. Michael Penix Jr. must do a lot to win this game in Week 1. 

The Buccaneers' better overall roster will show as the game develops. 

• Best Bet: Buccaneers -2.5 (-110) at Caesars

Panthers vs. Jaguars Odds, Sunday, 1:00 PM EST

Panthers: Spread +3.5 (-110), Moneyline +152

Jaguars: Spread -3.5 (-105), Moneyline -180

Total: Over/under 46.5 (-110/-110)

Both head coaches, Liam Coen and Dave Canales, have a chance of winning NFL Coach of the Year. The Jaguars and Panthers are both emerging teams with potential. 

This game will come down to which quarterback plays better. There is more continuity in Carolina, so we’ll trust Bryce Young to deliver over Trevor Lawrence. 

• Best Bet: Panthers +3.5 (-110) at Caesars

49ers vs. Seahawks Odds, Sunday, 4:05 PM EST

49ers: Spread -2.5 (-110), Moneyline -135

Seahawks: Spread +2.5 (-110), Moneyline +115

Total: Over/under 43.0 (-110/-110)

The San Francisco 49ers have a legitimate chance of winning the NFC Championship this season if they stay healthy. Christian McCaffrey has prepared his body for the long haul, and this should pay off in Week 1. 

The Seahawks are a new team with Sam Darnold. He is going to have a tough time being as good in Seattle as he was in Minnesota. 

Darnold had elite weapons like Justin Jefferson in Minnesota, but Seattle has a much more level playing field. 

• Best Bet: 49ers -2.5 (-110) at Caesars

Titans vs. Broncos Odds, Sunday, 4:05 PM EST

Titans: Spread +8.0 (-110), Moneyline +320

Broncos: Spread -8.0 (-110), Moneyline -420

Total: Over/under 42.5 (-110/-110)

Bo Nix finished second in NFL Offensive Rookie of the Year voting to Jayden Daniels in 2024. Nix had a great season one year ago, and he should build on this in Week 1. 

Cam Ward will make his first NFL start for a team without much talent, and this doesn’t usually translate to wins early in the season. Denver is a big favorite, but it’s worth laying the points.  

• Best Bet: Broncos -8.0 (-110) at Caesars

Texans vs. Rams Odds, Sunday, 4:25 PM EST

Texans: Spread +3.0 (-115), Moneyline +130

Rams: Spread -3.0 (-105), Moneyline -155

Total: Over/under 44.0 (-110/-110)

Matthew Stafford’s health is a massive concern heading into Sunday. Stafford will start, but if he isn’t mobile in the pocket, the Texans' defense could feast all afternoon. 

Houston for plus money has value with Stafford not entering this game at 100%. Look for CJ Stroud to lead his team to a win with a big performance. 

• Best Bet: Texans +3.0 (-115) at Caesars

Lions vs. Packers Odds, Sunday, 4:25 PM EST

Lions: Spread +2.5 (-110), Moneyline +118

Packers: Spread -2.5 (-110), Moneyline -140

Total: Over/under 47.0 (-110/-110)

The Packers and Lions will be competing for the NFC North title all season long. Green Bay made a huge splash, trading for Micah Parsons, and he should be in Jared Goff’s face all game. 

These two teams will likely split their games this season, with Green Bay’s home field making the difference in Week 1. 

• Best Bet: Packers -2.5 (-110) at Caesars

Ravens vs. Bills Odds, Sunday, 8:20 PM EST

Ravens: Spread +1.5 (-122), Moneyline -108

Bills: Spread -1.5 (+100), Moneyline -108

Total: Over/under 50.5 (-110/-110)

Josh Allen owned Lamar Jackson in 2024. He won the NFL MVP and advanced to the AFC Championship with a win over the Ravens. 

The Ravens must travel to Buffalo for this game on Sunday night, but they should be able to overcome the crowd and win. Baltimore has the most talented team in the AFC, and this will show in the season opener. 

Jackson was visibly upset after losing in the AFC Championship. He gets his second crack at Buffalo on the same field and won’t let this game go to waste.

• Best Bet: Ravens +1.5 (-122) at Caesars

Vikings vs. Bears Odds, Monday, 8:15 PM EST

Vikings: Spread -1.5 (-110), Moneyline -125

Bears: Spread +1.5 (-110), Moneyline +105

Total: Over/under 44.5 (-110/-110)

The Chicago Bears had a disappointing season in 2024, but they’re under a new head coach in Ben Johnson. Johnson had Caleb Williams in prime shape heading into the opener, and the same can’t be said for JJ McCarthy. 

McCarthy will make his first start of his career on Monday in a road game, and this usually doesn’t end well. Chicago is a very appealing as a home dog against the first time quarterback. 

• Best Bet: Bears +1.5 (-110) at Caesars

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