NFL Odds Week 2: Odds and Betting Lines for Every Game

• The Chiefs are the only team in the AFC West without a win

• The Packers dominated the Bears in Week 1

• The Bills are the current Super Bowl favorites after their win over the Ravens

The Kansas City Chiefs are at risk of starting 0-2 when they face the Philadelphia Eagles on Sunday. The Eagles started the season with a win over the Cowboys, despite looking shaky. 

The Super Bowl rematch is the highlight of the Week 2 NFL slate. Here, we will give a short analysis of each game on the slate with our pick. 

NFL Odds for Week 2

bet365 sportsbook is one of the best NFL betting sites, and we will be using their odds throughout the article. If you bet $5, you get $300 in bonus bets by using code WSN365 at registration.

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Commanders vs. Packers Odds, Thursday, 8:20 PM EST

• Commanders: Spread +3.5 (-110) | Moneyline +155

• Packers: Spread -3.5 (-110) | Moneyline -185

• Total: Over/Under 48.0 (-110/-110)

Odds from bet365 sportsbook.

The Green Bay Packers made the most significant statement of Week 1 with a dominant win over the Detroit Lions. The Packers had been the Lions' little brother for a couple of years, but this is changing in the NFC North. 

The Commanders picked up right where they started last year with a dominant victory over the New York Giants. Jayden Daniels threw for 233 yards with one touchdown and rushed for another 68 yards in the win. 

The Packers have the better team on paper, but Washington has been great in close games with Daniels at the helm. The current spread makes Washington the more appealing side of the line. 

Rams vs. Titans Odds, Sunday, 1:00 PM EST

• Rams: Spread -5.5 (-110) | Moneyline -250

• Titans: Spread +5.5 (-110) | Moneyline +205

• Total: Over/Under 42.0 (-110/-110)

Odds from bet365 sportsbook.

The NFL Offensive Rookie of the Year race is wide open after Cam Ward’s performance against the Broncos. Ward wasn’t very good in his debut, throwing for 112 yards while taking six sacks. 

He didn’t have much protection, but this is something he’ll have to get used to with his current offensive line. The Rams' defensive front should have a field day against Ward, who didn’t look comfortable. 

Los Angeles is known for their offense, but the defense will make the difference in Week 2.

Patriots vs. Dolphins Odds, Sunday, 1:00 PM EST

• Patriots: Spread +1.5 (-110) | Moneyline +105

• Dolphins: Spread -1.5 (-110) | Moneyline -125

• Total: Over/Under 44.0 (-110/-110)

Odds from bet365 sportsbook.

The New England Patriots and Miami Dolphins are both in a must-win situation on Sunday. It’s hard to declare Week 2 a must-win game, but each team isn’t very talented, and they need to stack wins to have a chance at the playoffs. 

The Buffalo Bills are in complete control of the AFC East, and these two teams are vying for a Wild Card position. The Patriots lost by a touchdown to the Raiders, and the Dolphins were embarrassed by the Colts in Week 1. 

The Patriots struggle in Miami, but they’re the better overall team.

Jaguars vs. Bengals Odds, Sunday, 1:00 PM EST

• Jaguars: Spread +3.5 (-115) | Moneyline +155

• Bengals: Spread -3.5 (-105) | Moneyline -185

• Total: Over/Under 49.5 (-110/-110)

Odds from bet365 sportsbook.

The Jaguars' offense looked solid in Week 1 against the Panthers, but Trevor Lawrence still has a lot of areas to improve. Jacksonville ran the ball well with Trevor Etienne Jr., who had 143 yards on the ground. 

Lawrence was 19-31 for 178 yards with one touchdown and one interception. For Jacksonville to advance to 2-0, Lawrence must be better because he has to face Joe Burrow. 

Burrow was bad against the Browns, but the Bengals can explode on offense with Ja’Marr Chase and Tee Higgins.

Seahawks vs. Steelers Odds, Sunday, 1:00 PM EST

• Seahawks: Spread +3.0 (-115) | Moneyline +125

• Steelers: Spread -3.0 (-105) | Moneyline -150

• Total: Over/Under 40.0 (-110/-110)

Odds from bet365 sportsbook.

The Pittsburgh Steelers looked like a potential AFC North champion in their win over the New York Jets. The Steelers defeated the Jets by two points in the season opener, and their offense looked legitimate. 

Pittsburgh has lacked a starting quarterback for years, and now Aaron Rodgers is at the helm. Pittsburgh worked its play-action passing game, which helped Rodgers to settle into the game. 

The Seahawks had chances against the 49ers late in their Week 1 battle, but Sam Darnold didn’t look comfortable. Both quarterbacks should be better, but Pittsburgh has the edge at home.

Browns vs. Ravens Odds, Sunday, 1:00 PM EST

• Browns: Spread +12.5 (-110) | Moneyline +550

• Ravens: Spread -12.5 (-110) | Moneyline -800

• Total: Over/Under 45.0 (-110/-110)

Odds from bet365 sportsbook.

Lamar Jackson finished as the runner-up in the NFL MVP race to Josh Allen, and he also lost to the quarterback in the first week of the season. The Ravens coughed up an easy win against the Bills to open the year, and should come out very angry in Week 2. 

The Browns played the Bengals tight in their first game. We don’t believe they stand a chance in Week 2 on the road, but 11.5 points is a massive spread. 

We’re taking Cleveland because their defense should be able to keep them in the game. Joe Flacco needs to lead a few touchdown drives, but Baltimore’s defense was terrible against the Bills in Week 1.

Bears vs. Lions Odds, Sunday, 1:00 PM EST

• Bears: Spread +5.5 (-110) | Moneyline +205

• Lions: Spread -5.5 (-110) | Moneyline -250

• Total: Over/Under 47.5 (-110/-110)

Odds from bet365 sportsbook.

Jared Goff is now 3-18-1 as a starting quarterback without Ben Johnson or Sean McVay calling the plays. Detroit didn’t score an offensive touchdown until garbage time in Week 1 against the Packers. 

Goff was 31-39 for 225 yards with one touchdown and one interception. His pick came in the red zone at a critical time in the game. Sam LaPorta was the only bright spot for Detroit.

Ben Johnson knows everything about the Lions, and this will pay dividends in Week 2.

Bills vs. Jets Odds, Sunday, 1:00 PM EST

• Bills: Spread -6.5 (-110) | Moneyline -315

• Jets: Spread +6.5 (-110) | Moneyline +255

• Total: Over/Under 45.5 (-110/-110)

Odds from bet365 sportsbook.

The Jets looked much better than expected in Week 1 against the Steelers. Justin Fields completed nearly 73% of his passes for 218 yards with one touchdown. 

He also ran the ball 12 times for 48 yards with two touchdowns as well. Fields can give the Bills offense trouble because he’s very similar to Lamar Jackson, and the former MVP was a big challenge for Buffalo in Week 1. 

New York is getting a full touchdown and PAT at home in this division game, which is a very juicy number.

Giants vs. Cowboys Odds, Sunday, 1:00 PM EST

• Giants: Spread +6.0 (-110) | Moneyline +210

• Cowboys: Spread -6.0 (-110) | Moneyline -260

• Total: Over/Under 44.5 (-110/-110)

Odds from bet365 sportsbook.

The New York Giants dropped the ball in the season opener against the Commanders. They played Washington tight last season, but lost 21-6 to open the year. 

The offense looked terrible throughout the entire game, despite Russell Wilson's efforts. The saving grace for the Giants is that Dallas’ defense isn’t robust. 

The Giants must get the ball to Malik Nabers early in the game. They also have to find their rushing attack because Wilson led the team on the ground in the opener.

49ers vs. Saints Odds, Sunday, 1:00 PM EST

• 49ers: Spread -4.5 (-105) | Moneyline -220

• Saints: Spread +4.5 (-115) | Moneyline +180

• Total: Over/Under 44.0 (-110/-110)

Odds from bet365 sportsbook.

George Kittle is expected to be sidelined for weeks with a hamstring injury. This is a significant blow for San Francisco, but Christian McCaffrey appears to be healthy. 

McCaffrey is one of the most talented players in the NFL. McCaffrey had 22 carries for 69 yards and nine catches for 73 yards through the air. 

The New Orleans Saints shouldn’t provide much of a challenge for the 49ers as the game develops.

Broncos vs. Colts Odds, Sunday, 4:05 PM EST

• Broncos: Spread -2.5 (-110) | Moneyline -130

• Colts: Spread +2.5 (-110) | Moneyline +110

• Total: Over/Under 42.5 (-110/-110) at bet365

Odds from bet365 sportsbook.

The Indianapolis Colts had the best start to the season in the NFL, scoring on seven consecutive possessions. Daniel Jones was slandered in the offseason for his play as a Giant, but he got a fresh start in Indianapolis and started strong. 

Jones threw for 272 yards with one touchdown. He carried the ball seven times for 26 yards and two touchdowns. While Jones was fantastic, Miami didn’t provide much resistance. 

Denver has one of the best defenses in the NFL, and the Colts should meet their match.

Panthers vs. Cardinals Odds, Sunday, 4:05 PM EST

• Panthers: Spread +6.5 (-110) | Moneyline +245

• Cardinals: Spread -6.5 (-110) | Moneyline -305

• Total: Over/Under 45.0 (-110/-110)

Odds from bet365 sportsbook.

The Carolina Panthers improved a lot as the 2025 season developed. They were smoked in their season opener against the Jaguars. 

The Cardinals took care of business on the road against the Saints. Kyler Murray progressed from last season, and they look like a legitimate team in the NFC West.

Eagles vs. Chiefs Odds, Sunday, 4:25 PM EST

• Eagles: Spread -1.0 (-110) | Moneyline -115

• Chiefs: Spread +1.0 (-110) | Moneyline -105

• Total: Over/Under 47.0 (-110/-110)

Odds from bet365 sportsbook.

The Kansas City Chiefs are the only team in the AFC West that has not won a game after the first week. It’s early, but the Chiefs didn’t look good in their season opener against the Chargers. 

The Eagles crushed the Chiefs in the Super Bowl last season, and this game may follow the same trajectory. We fear that the best of Kansas City is in the rearview mirror.

Falcons vs. Vikings Odds, Sunday, 8:20 PM EST

• Falcons: Spread +5.0 (-110) | Moneyline +190

• Vikings: Spread -5.0 (-110) | Moneyline -230

• Total: Over/Under 45.5 (-110/-110)

Odds from bet365 sportsbook.

The Atlanta Falcons lost on a missed field goal to their NFC South rivals, the Tampa Bay Buccaneers, in Week 1. While the Falcons didn’t make plays in crunch time, they still had a solid passing game with Michael Penix Jr. 

Minnesota’s defense is legitimate, but Penix Jr. is ahead of JJ McCarthy in the developmental process.

Buccaneers vs. Texans Odds, Monday, 8:15 PM EST

• Buccaneers: Spread +3.0 (-120) | Moneyline +125

• Texans: Spread -3.0 (+100) | Moneyline -150

• Total: Over/Under 42.5 (-110/-110)

Odds from bet365 sportsbook.

The Tampa Bay Buccaneers have dominated the NFC South for years. They’re consistently disrespected, and we think this line is off on Bet365. 

Tampa Bay should be favored in this contest. The Houston Texans didn’t have a good opener, and the Buccaneers present a lot of challenges on both sides of the ball.

Chargers vs. Raiders Odds, Monday, 10:10 PM EST

• Chargers: Spread -3.5 (-105) | Moneyline -190

• Raiders: Spread +3.5 (-115) | Moneyline +160

• Total: Over/Under 47.0 (-110/-110)

Odds from bet365 sportsbook.

The Las Vegas Raiders started their season with a win over the Patriots. This was an impressive win for the Raiders, even though the Patriots aren’t as good as people thought. 

Nevertheless, the Chargers have extended rest, and they’re the better team. The winner will move to first place in the AFC West, making this game critical, and we give the edge to the Chargers.

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