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NFL Early Odds Week 3: Odds and Betting Lines for Every Game

Published: September 16, 2025, 10:00 AM ET
11 min read
  • The Bengals' Super Bowl odds went from 25-1 to 50-1 to win the Super Bowl after Joe Burrow’s injury 

  • The Packers are the new Super Bowl favorites

  • Lions vs Ravens highlights the Week 3 slate 

The Bengals will be without Joe Burrow for the next three months after the quarterback suffered a toe injury on Sunday. Cincinnati is still undefeated and will face Minnesota in Week 3.

This game, along with a potential Super Bowl matchup between the Lions and Ravens, highlights the Week 3 slate. Here, we will give a short analysis of each game on the slate with our pick. 

NFL Early Odds for Week 3

bet365 sportsbook is one of the best NFL betting sites, and we will be using their odds throughout the article. If you bet $5, you get $300 in bonus bets by using code WSN365 at registration.

MatchupSpreadMoneylineTotal
Dolphins
vs
Bills
+12.5 (-110)+550O 49.5 (-110)
-12.5 (-110)-800U 49.5 (-110)
Falcons
vs
Panthers
-5.0 (-110)-240O 43.5 (-110)
+5.0 (-110)+195U 43.5 (-110)
Bengals
vs
Vikings
+3.0 (-115)+135O 41.5 (-110)
-3.0 (-105)-160U 41.5 (-110)
Packers
vs
Browns
-8.0 (-110)-400O 42.5 (-110)
+8.0 (-110)+320U 42.5 (-110)
Texans
vs
Jaguars
+1.5 (-115)-105O 43.5 (-110)
-1.5 (-105)-115U 43.5 (-110)
Colts
vs
Titans
-3.5 (-110)-170O 43.5 (-110)
+3.5 (-110)+145U 43.5 (-110)
Rams
vs
Eagles
+3.5 (-115)+160O 44.5 (-110)
-3.5 (-105)-190U 44.5 (-110)
Raiders
vs
Commanders
+3.5 (-110)+155O 44.5 (-110)
-3.5 (-110)-185U 44.5 (-110)
Jets
vs
Buccaneers
+7.0 (-105)+270O 45.5 (-110)
-7.0 (-115)-340U 45.5 (-110)
Steelers
vs
Patriots
+1.0 (-105)-115O 44.5 (-110)
+1.0 (-115)-105U 44.5 (-110)
Broncos
vs
Chargers
+2.5 (-110)+125O 45.5 (-110)
-2.5 (-110)-150U 45.5 (-110)
Saints
vs
Seahawks
+7.5 (-110)+325O 41.5 (-110)
-7.5 (-110)-425U 41.5 (-110)
Cardinals
vs
49ers
+1.5 (-110)+105O 43.5 (-110)
-1.5 (-110)-125U 43.5 (-110)
Cowboys
vs
Bears
+1.5 (-110)+100O 50.0 (-110)
-1.5 (-110)-120U 50.5 (-110)
Chiefs
vs
Giants
-5.5 (-115)-270O 44.5 (-110)
+5.5 (-105)+220U 44.5 (-110)
Lions
vs
Ravens
+6.0 (-110)+220O 51.5 (-110)
-6.0 (-110)-270U 51.5 (-110)

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Odds for NFL Games in Week 3

Dolphins vs. Bills Odds, Thursday, 8:20 PM EST

The Miami Dolphins and Buffalo Bills will compete in an AFC East battle on Sunday. The Dolphins lost to the Patriots in a difficult game for the entire team.

Miami consistently had presnap penalties, which killed drives throughout the game. Mike McDaniel seems lost, and if his team doesn’t have a good showing on Thursday, he could be fired. 

The Bills dominated the Jets, and Josh Allen didn’t even throw a touchdown pass. While Buffalo is very good, New York isn’t even close in terms of talent. Buffalo should have a Week 2 repeat because they’re the much better team. 

Raiders vs. Commanders Odds, Sunday, 1:00 PM EST

Former NFL Offensive Rookie of the Year Jayden Daniels has a knee injury, which may keep him sidelined on Sunday. If this is the case, the Raiders have a significant edge. 

Washington faced Green Bay on Thursday Night Football in Week 2, and didn’t look like a competent football team. Las Vegas is better than many people expected, and it should provide a challenging gaming experience. 

Geno Smith has settled in nicely to Pete Carroll’s offense, and the Commanders have struggled on defense. 

Falcons vs. Panthers Odds, Sunday, 1:00 PM EST

The Falcons and Panthers will compete in a critical NFC South matchup on Sunday. Atlanta earned their first win of the season on Sunday after beating the Minnesota Vikings. 

Atlanta’s offense didn’t need to throw the ball with Michael Penix. The team elected to pound the rock with Bijan Robinson, and it worked wonders. 

Carolina will have a tough time stopping Robinson and the Falcons' multi-dimensional offense in Week 2. The Panthers improved after their opening game, but they’re not on the same level as Atlanta. 

Packers vs. Browns Odds, Sunday, 1:00 PM EST

The Green Bay Packers are Super Bowl favorites after two weeks of games. They dominated the Lions in Week 1, and they blew the Commanders off the field last Thursday. 

Micah Parsons has been a nightmare on third down, and this should continue against the Browns. Joe Flacco isn’t very mobile in the pocket, and Cleveland doesn’t have a very talented offensive line. 

If Green Bay pressures Flacco, this game will be over before it starts. 

Steelers vs. Patriots Odds, Sunday, 1:00 PM EST

If you are a Patriots fan, you should feel a lot better about your team after their Week 2 win. New England hadn’t won a game in Miami since 2019, and the team got the job done for Mike Vrabel’s first victory. 

Drake Maye was fantastic throughout the contest. The team had countless procedural penalties, but this should improve at home. 

Pittsburgh's defense has been terrible the past two weeks, which gives New England a realistic chance in this contest. We’ll take the Patriots as a short home underdog. 

Rams vs. Eagles Odds, Sunday, 1:00 PM EST

The Philadelphia Eagles should be loaded with confidence after going to Arrowhead Stadium and beating the Kansas City Chiefs. Philadelphia has now beaten the most dominant force in football in two consecutive games, causing many to shed doubt on Patrick Mahomes. 

The Rams almost beat the Eagles in the NFC Divisional Round one year ago. Los Angeles is 2-0, but Los Angeles has the team to compete with Philadelphia. 

Matthew Stafford has been successful against the Eagles, and their passing attack should keep them in the contest. 

Colts vs. Titans Odds, Sunday, 1:00 PM EST

Daniel Jones is in line to win the NFL Comeback Player of the Year in 2025 because he has been a different quarterback since joining the Colts. Jones is second in the NFL in passing yards with 588, and he is very comfortable in the offense. 

Titans quarterback Cam Ward has shown some bright flashes, but he isn’t a player Indianapolis should fear. The Colts have the team to confuse the young quarterback, and this should result in a win on the road. 

Bengals vs. Vikings Odds, Sunday, 1:00 PM EST

Joe Burrow suffered a toe injury and will miss the next three months of the season. Burrow hasn’t been able to stay healthy in his career, but he always has one of the worst offensive lines in the NFL. 

Jake Browning will start for the Bengals, and he is a reliable backup who has played a lot of football. The quarterback did throw three interceptions on Sunday, but we trust him to be better moving forward. 

The Bengals are a dream matchup for the Vikings without Burrow. Minnesota has struggled to score with JJ McCarthy, but Cincinnati gives up points. They also have a defense that’s very confusing for opposing quarterbacks.

Texans vs. Jaguars Odds, Sunday, 1:00 PM EST

The Houston Texans' offense hasn’t looked serviceable this season with CJ Stroud. The quarterback has missed too many throws, which is surprising given his talent level. 

The Jaguars are coming off a tough loss to the Bengals 31-27, where they failed to capitalize on three second-half interceptions. Neither team is overly impressive, but Houston’s defense should be the biggest difference maker. 

Jets vs. Buccaneers Odds, Sunday, 1:00 PM EST

The Buccaneers are turning into the comeback kings, with their first two wins coming after trailing in the fourth quarter. The New York Jets were blown off the field by the Bills in Week 2, so these teams are in entirely different spots after the first two games of the season. 

Baker Mayfield continues to deliver, and Tampa Bay is returning home for this contest after two weeks on the road. The team’s offense and defense are firing on all cylinders, and this should result in a cover on Sunday.

Saints vs. Seahawks Odds, Sunday, 4:05 PM EST

The Seahawks' offense exploded against the Pittsburgh Steelers on Sunday. Darnold was 22-33 for 295 yards and two touchdowns. 

The Steelers forced Darnold into two interceptions, but could not capitalize on the mistakes at any point in the game. If the Seahawks bring this passing attack on Sunday, the Saints won’t stand a chance. 

Spencer Rattler isn’t an NFL starting quarterback, and this will continue to show weekly. 

Broncos vs. Chargers Odds, Sunday, 4:05 PM EST

The Denver Broncos have regressed in the past two weeks. They lost 29-28 to the Colts on Sunday, and mental mistakes cost them this game. The positive is that Bo Nix was much better in Week 2 than in Week 1. 

The Chargers have been outstanding this season, and they have meshed well since their opening game of the year against the Chiefs. 

If Justin Herbert continues to play at an NFL MVP level, Los Angeles should take this game at home. 

Cardinals vs. 49ers Odds, Sunday, 4:25 PM EST

Mac Jones doesn’t have the best reputation for a starting quarterback in the NFL, but he looked the part on Sunday. Jones stepped into the mix for the injured Brock Purdy and played very well against the Saints. 

Jones was 26-39 for 279 yards and three touchdowns. We’re counting on Jones to bring this same effort to Sunday's NFC West matchup against the Cardinals. 

Arizona advanced to 2-0, but they haven’t played any legitimate teams. San Francisco will be their first formidable opponent, and we’re counting on them to fail. 

Cowboys vs. Bears Odds, Sunday, 4:05 PM EST

In 2022, Ryan Poles took over as the Bears' GM and said we’re going to take the NFC North and never give it back again. The Bears are 3-17 in the NFC North since Poles took over as GM, so he hasn’t upheld his promise. 

The Bears can beat the Cowboys, but they need better quarterback play from Caleb Williams. The Detroit Lions defeated the Chicago Bears on Sunday, and they’ll look to rebound.

Luckily, Dallas' defense has been one of the worst in the NFL this season. 

Chiefs vs. Giants Odds, Sunday, 8:20 PM EST

The Kansas City Chiefs are in desperate need of a win on Sunday night at MetLife Stadium. The New York Giants also need a win, but nobody expected them to be good this season. 

Kansas City is expected to compete for a Super Bowl, but they started 0-2 this season. Patrick Mahomes hasn’t been 0-2 since his sophomore year of high school. 

The Chiefs have been victims of a strict schedule to open the year. They’ll beat Brian Daboll’s Giants on Sunday. 

Lions vs. Ravens Odds, Sunday, 8:15 PM EST

We believe the Ravens are the best team in the AFC Conference. The Lions are one of the best teams in the NFC Conference

Even though Detroit had a great response in Week 2 against the Bears, we give the Ravens the edge in this contest.

Lamar Jackson is the most dynamic quarterback in the NFL, and he should give Detroit’s defense countless issues in this contest. 

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Tanner Kern

Tanner Kern

Sports Betting Analyst & On-Air Host

Expertise:
MLB
NCAAB
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Online Sports Betting
Tanner Kern has been working in the betting industry since 2020. He currently is a social media content creator at DraftKings and contributes to multiple sites in addition to WSN, including Forbes and VSiN. He is also the cohost of the podcast Ride the Line at WSN.
Email: [email protected]
Nationality: American
Education: M.S in Sports Journalism
Favourite Sportsbook: Fanatics Sportsbook
Favourite Casino: Caesars Palace
Experience: 4 years
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