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Best Bills vs Eagles Prop Bets: Can Both Red-Hot Offenses Take Flight?

Published: December 27, 2025, 09:00 AM ET
5 min read
  • Saquon Barkley has rushed for over 100 yards in two of his last three games

  • James Cook has rushed for over 100 yards in four of his last five games

  • Only one of the last seven quarterbacks to face the Bills has thrown for more than 200 yards

One of the most anticipated games on the Week 17 schedule features the Buffalo Bills hosting the Philadelphia Eagles. This is potentially a Super Bowl preview if both teams can continue to build momentum heading into the playoffs. It’s also a game that could see plenty of points, as both teams have explosive, dual-threat quarterbacks, as well as a contingent of skill players who are capable of performing at a high level.

The Bills are led by reigning MVP Josh Allen, who is a long shot to win MVP this season despite carrying the Bills at times. At the moment, Allen is more interested in leading Buffalo to another AFC East title. As for the Eagles, they’ve already wrapped up the NFC East this season. They have turned their attention to winning the NFC and making a return trip to the Super Bowl.

Best Bills vs. Eagles Prop Bets

With stars on both sides, especially at the quarterback position, the Bills-Eagles game is perfect for prop bets. After taking an in-depth look at this game, we picked our three favorite prop bets for this game.

The odds for our bets come from bet365 Sportsbook, which is one of the best prop betting sites, offering a huge selection of NFL props. New users who register with our promo code WSN365 will get $150 in bonus bets - win or lose.

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Best Bills vs. Eagles Prop BetsOddsGet $150 in Bonus Bets at bet365
Saquon Barkley Over 83.5 Rushing Yards-110CLAIM HERE
James Cook Over 90.5 Rushing Yards-110CLAIM HERE
Jalen Hurts Under 191.5 Passing Yards-110CLAIM HERE

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Saquon Barkley Over 83.5 Rushing Yards (-110) at bet365 Sportsbook 

It hasn’t been easy to get behind Barkley this season, even if he’s surpassed 1,000 rushing yards on the season. Fortunately, he has a favorable matchup this week against a Buffalo defense that’s allowed the third-most rushing yards in the league this season. The Bills give up 5.3 yards per carry, which should mean Barkley will have opportunities to break off big runs and rack up plenty of yards.

Keep in mind that Barkley is trending in the right direction. He rushed for 132 yards last week against the Commanders and had 122 yards against the Chargers earlier this month. Granted, those are two of the only four games this season he’s gone over 83.5 rushing yards. But with Barkley getting at least 20 carries in three straight games and facing a defense that struggles against the run, he should at least get close to rushing for 100+ yards yet again.

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James Cook Over 90.5 Rushing Yards (-110) at bet365 Sportsbook 

The Eagles aren’t quite as poor against the run as Buffalo’s defense, but they have been vulnerable at times on the ground. The Eagles give up over 123 rushing yards per game and 4.4 yards per carry. That’s enough to believe that Cook can continue to have a productive season and put together a strong performance against the Philadelphia defense.

Cook has surpassed 100 rushing yards in four of his last five games. He’s also averaged at least 4.5 yards per carry in four of those five games, and if that trend continues, Cook should be able to surpass 90 yards on the ground. When the Bills have been at their best this season, they’ve leaned on their rushing attack. For a cold-weather game, that will likely be the plan again, giving Cook more than enough carries to put together another 100-yard game.

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Jalen Hurts Under 191.5 Passing Yards (-110) at bet365 Sportsbook

While the Bills have been hurt against the run, they’ve been tough against the pass this season. The Buffalo defense has conceded the fewest passing yards in the NFL, yielding just 6.6 yards per pass. In fact, six of the last seven quarterbacks to face the Bills have fallen short of 200 passing yards, with most not even getting close. 

Obviously, that’s not a good omen for Hurts, who has been inconsistent throwing the ball this year. Even in one of his better games last week, Hurts managed only 185 passing yards. In 15 games, Hurts has been held to fewer than 190 passing yards eight times. While he’s had a few high-volume passing games, it seems unlikely that he’ll be able to do that against the Buffalo defense.

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

Expertise:
MLB
NCAAB
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Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
Email: bryan.zarpentine@wsn.com
Nationality: American
Education: Bachelor of Arts
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Experience: 14 years
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