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Best MLB Home Run Props Today: Time to Target the Postseason’s Hottest Hitters

Published: October 8, 2025, 08:36 AM ET
4 min read
Best MLB Home Run Props Today 2025 10 08

Even with just two games on the schedule, we hit on three of our four home run targets yesterday. On Wednesday, we have the benefit of having four games on the schedule. That extra flexibility allowed us to dig a little deeper and choose some not-so-obvious targets to go deep on Wednesday.

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Wednesday’s odds are from FanDuel Sportsbook, which is the perfect place to bet on what could be among the best days of the MLB season. FanDuel is also welcoming to new customers, who receive $300 in bonus bets if they win their first bet.

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Home Run Picks for Wednesday, October 8

Vladimir Guerrero Jr. Anytime Home Run (+340) at FanDuel Sportsbook

It’s downright foolish not to bet on Guerrero right now. In three playoff games, he’s 8 for 13 with three home runs. Those numbers are just mind-boggling, even in a small sample size. Unless the Yankees walk him in every at-bat, assume he’s going to stay hot.

Even if four homers in four games seems unlikely, keep in mind that Guerrero is 4 for 5 in his career against Cam Schlitter, who starts Game 4 for the Yankees. Despite Schlitter’s brilliant start in the Wild Card Round, Guerrero matches up well against him.

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Enrique Hernandez Anytime Home Run (+630) at FanDuel Sportsbook

Hernandez is such an anomaly because his postseason numbers by far eclipse his regular-season numbers. He’s up to his old tricks, going 5 for 16 with two doubles in the playoffs thus far. With 15 career postseason home runs in 90 games, one has to assume it’s only a matter of time until Hernandez goes deep.

Game 4 looks like a good opportunity to target Hernandez. He’s 4 for 11 in his career against Aaron Nola, who gets the start on Wednesday. More importantly, three of those four hits were home runs, so it makes all the sense in the world for Hernandez to continue his playoff heroics with a home run against Nola in Game 4.

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Mookie Betts Anytime Home Run (+480) at FanDuel Sportsbook

Speaking of Nola, Game 4 will be a big test for him. He has a long playoff track record, but he also posted a 6.01 ERA this season. Nola also gave up 18 home runs over just 90.1 innings of work in the season, so he’ll be vulnerable against this dangerous Los Angeles lineup.

While lefties typically get the better of Nola, it’s Betts who has the best career numbers against him of anyone on the Dodgers. He’s 9 for 23 with a double and two home runs in his career against Nola. Betts is also 7 for 18 with three doubles in the playoffs, so he’s swinging a good bat and could be poised to go deep in a favorable matchup against Nola.

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Jackson Chourio Anytime Home Run (+470) at FanDuel Sportsbook

The Cubs should feel good about Jameson Taillon starting an elimination game for them. However, keep in mind that Taillon is vulnerable to the long ball. In three of the four starts he made in September, Taillon gave up multiple home runs. 

Right-handed hitters have done more damage against him this year than lefties, which points us toward Chourio. It also helps that Chourio is 7 for 13 with two doubles and a home run in his career against Taillon. Even with some concerns over his hamstring, we can’t ignore the fact that Chourio is 5 for 7 with a double and a homer in this series, so we have to take a chance on Milwaukee’s hottest hitter.

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

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Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
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