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Best MLB Prop Bets Today: Bet on Padres and Diamondbacks to Shine

Published: May 21, 2025, 10:00 AM ET
4 min read
Best MLB Prop Bets Today May 21

We took an aggressive approach on Tuesday and came out on the plus side of things. We’re not going to be quite as aggressive with Wednesday’s prop bets, but there is still a ton of value. Some of these picks definitely swing for the fences, so to speak.

Best MLB Prop Bets Today: Padres vs. Blue Jays (7:07 PM, EST)

Randy Vasquez to Record Win

This falls into the category of an aggressive pick, in part because the Padres have lost four in a row. They’ve also scored just three total runs in those games, so there’s no guarantee Vasquez will get the run support he needs to win. However, San Diego has won the last three games Vasquez has started, in part because he’s allowed just four total runs across 17 innings of work in those starts. Vasquez has also picked up the win in each of his last two starts. The Blue Jays are scuffling as well, losing four of their last seven games, while scoring three runs or less in five of their last six games. That’s a good sign that Vasquez will have a good night and help the Padres snap their losing streak.

Kevin Gausman Over 5.5 Hits

We also feel confident in Vasquez and the Padres because Gausman has been unreliable this season. He’s 3-4 with a 4.59 ERA, and the Blue Jays have lost four of his last five starts. Gausman has also allowed at least six hits in four of his last six starts, including 17 hits in 11 innings across his last two outings. While the San Diego lineup has been quiet lately, several Padres have an excellent track record against Gausman. If the Padres can break out of their team-wide slump, they have a chance to do it in a big way against Gausman, which is why we’re going against the grain to fade Toronto’s starter in this game.

Fernando Tatis Over 1.5 Total Bases

Tatis is one of the Padres who has had past success against Gausman. He’s 8 for 17 (.471) with three extra-base hits in his career against Gausman. Tatis has also stayed productive during San Diego’s losing streak. He has at least one hit in all four of the team’s recent losses, giving Tatis at least one hit in 11 of his last 12 games. Tatis also has four home runs and two doubles during that 12-game stretch, so he’s still showcasing plenty of power. Given his past against Gausman, this is a good opportunity for Tatis to lead the way in a breakout game for the San Diego lineup.

Best MLB Prop Bets Today: Diamondbacks vs. Dodgers (10:10 PM, EST)

Dustin May Under 16.5 Outs

May has had an uneven season thus far. He’s only 1-4 with a 4.43 ERA, taking the loss in each of his last three starts. At this point, the Dodgers can’t have much faith in May being able to go deep in this game. He’s been under 16.5 outs in four of his eight starts, so they’ve pulled the plug early on him before. This is also the second time May is facing the Diamondbacks this month. The Arizona lineup should be ready to attack him and force him out of the game early. The D’Backs are also averaging 6.4 runs per game in their last seven games, giving May a red-hot lineup to face.

Josh Naylor Over 1.5 Hits/Runs/RBI

Naylor has had plenty of past success against May, going 4 for 11 (.364) with a double. He’s also been an underrated part of Arizona’s lineup this year, contributing 17 extra-base hits and 29 RBI. Naylor hits behind Arizona’s best hitters, which presents plenty of RBI opportunities for him. That makes over 1.5 hits/runs/RBI the ideal bet for him. Despite going hitless on Tuesday, Naylor has hit this prop eight times in his last 12 games, including three times in six games against the Dodgers, so he’s in excellent shape to hit it again on Wednesday.

tip_r

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

Sports Betting Analyst

Expertise:
MLB
NCAAB
NFL
Online Sports Betting
Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
Email: [email protected]
Nationality: American
Education: Bachelor of Arts
Favourite Sportsbook: BetMGM Sportsbook
Favourite Casino: BetMGM Casino
Experience: 14 years
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