NFL Odds Week 10: Odds and Betting Lines for Every Game

• Patriots vs. Buccaneers headlines the week

• The Lions look to rebound after a home loss to the Vikings

• The Packers and Eagles will battle in what could be an NFC Championship preview 

The AFC and NFC contenders are beginning to take shape in the NFL. We will see two of the best teams in the league compete in Week 10 with the Patriots and Buccaneers. For more info on the team standings, check our latest NFC Championship odds, along with AFC Championship odds.

Philadelphia vs. Green Bay is also a marquee matchup on the Week 10 slate. The odds have been released, and it’s time to examine the matchups. 

We just crossed the halfway point in the regular season, so we have valuable stats for each team. Here, we will give a short analysis of each game on the board with the odds. 

NFL Odds for Week 10

Odds courtesy of bet365 sportsbook. bet365 is ranked as one of our top recommended NFL betting sites. If you bet $5, you get $200 in bonus bets by using our promo code WSN365 at registration.

Bet $5 at bet365 and Get $200 in Bonus Bets

Raiders vs. Broncos Odds, Thursday, 8:15 PM EST

• Raiders: Spread +9.0 (-115) | Moneyline +375

• Broncos: Spread -9.0 (-105) | Moneyline -500

• Total: Over/Under 41.5 (-110/-110)

The Broncos have built momentum behind second-year quarterback Bo Nix, who is starting to improve. The team is coming off a game-winning field goal against the Texans. 

Their defense ranks near the top of the league in many categories. Meanwhile, the Raiders are still searching for consistency on both sides of the ball. 

Las Vegas got bested on Sunday in overtime by the Jaguars. They have been on a significant losing streak, and it should continue in prime time. 

The Pete Carroll experiment hasn’t lived up to the hype, and Las Vegas is already looking to the 2026 NFL Draft. 

Falcons vs. Colts Odds, Sunday, 9:30 AM EST

• Falcons: Spread +5.5 (-110) | Moneyline +225

• Colts: Spread -5.5 (-110) | Moneyline -275

• Total: Over/Under 48.5 (-110/-110)

The Atlanta Falcons had plenty of chances to beat the New England Patriots on Sunday, but failed to convert in key opportunities. Michael Penix and Bijan Robinson looked solid in the loss, which is one positive for the team. 

The Colts should be hungry to bounce back as well in Berlin. Indianapolis had been nearly unstoppable all season, but the Steelers dominated them in Week 9. 

Daniel Jones was careless with the ball, which isn’t something we have seen from the potential MVP quarterback this season. Indianapolis is the better team, so expect them to respond on Sunday. 

Giants vs. Bears Odds, Sunday, 1:00 PM EST

• Giants: Spread +3.5 (-110) | Moneyline +160

• Bears: Spread -3.5 (-110) | Moneyline -190

• Total: Over/Under 48.0 (-110/-110)

The Giants are dealing with plenty of growing pains this season. They have been riddled with injuries, including Cam Skattebo and Malik Nabers. 

Once these two players’ seasons ended, it was going to be a long year for the Giants. They’ll have trouble keeping up with the Bears, who have been fantastic this season.

Chicago is 5-3, and in second place in the NFC North odds. The Bears won a shootout against the Bengals on Sunday, where the offense looked nearly unstoppable. 

If Caleb Williams continues to play at a high level, Chicago should be victorious on Sunday. 

Bills vs. Dolphins Odds, Sunday, 1:00 PM EST

• Bills: Spread -9.5 (-110) | Moneyline -500

• Dolphins: Spread +9.5 (-110) | Moneyline +375

  Total: Over/Under 50.0 (-110/-110)

The Buffalo Bills beat the Dolphins at home earlier this season. Now, they’ll head to Miami for the second game of the year against their AFC East rival. 

The Bills are coming off a win over the Kansas City Chiefs. Josh Allen put on an MVP-level performance, and James Cook carried the team on the ground. 

Buffalo probably won’t be able to match their level of play from last week on Sunday, but they’re better in every area of the game compared to the Dolphins. Tua Tagovailoa has turned the ball over too much to trust the Dolphins in Week 10. 

Ravens vs. Vikings Odds, Sunday, 1:00 PM EST

• Ravens: Spread -4.0 (-110) | Moneyline -210

• Vikings: Spread +4.0 (-110) | Moneyline +175

• Total: Over/Under 48.0 (-110/-110)

Lamar Jackson is back for the Ravens, and it has transformed them into a different team. Baltimore was spiraling without the quarterback as he was dealing with a hamstring injury. 

He looked fantastic in his return against the Dolphins, throwing for four touchdowns. However, the Vikings will be a much tougher challenge for Baltimore.

Minnesota upset Detroit as an 8.5-point underdog on Sunday. JJ McCarthy led the team to a win, and their defense was fantastic. I believe this will be the case once again, allowing the Vikings to keep the game close. 

Browns vs. Jets Odds, Sunday, 1:00 PM EST

• Browns: Spread +2.0 (-110) | Moneyline +110

• Jets: Spread -2.0 (-110) | Moneyline -130

• Total: Over/Under 37.0 (-110/-110)

The New York Jets aren’t favorites much over the course of an NFL season. Yet, they’re listed as field goal favorites against the Browns on Sunday. 

New York is coming off their first win over the season in comeback fashion against the Bengals. Justin Fields looked like an NFL quarterback in the season half, but he has been very inconsistent this season.

Fields’ inconsistent quarterback play makes this game tough from a betting perspective. It’s hard not to take the points with the Browns because they have the best defense in the league. 

Patriots vs. Buccaneers Odds, Sunday, 1:00 PM EST

• Patriots: Spread +2.5 (-110) | Moneyline +120

• Buccaneers: Spread -2.5 (-110) | Moneyline -140

• Total: Over/Under 48.5 (-110/-110)

The Patriots and Buccaneers will battle in what is expected to be the best game of the week. New England continues to win games, but they haven’t faced many tough opponents. 

The Patriots lead the AFC East, and if they want to stay at the top, they must win on Sunday. Tampa Bay leads the NFC South in odds, and they look outstanding. 

The Buccaneers will be hard to stop for the Patriots because they’re getting healthy coming off a bye week, and they have a more veteran roster. 

Baker Mayfield and Drake Maye should put on a show at quarterback, but Tampa Bay has the slight edge at home.  

Saints vs. Panthers Odds, Sunday, 1:00 PM EST

• Saints: Spread +5.5 (-110) | Moneyline +205

• Panthers: Spread -5.5 (-110) | Moneyline -250

• Total: Over/Under 40.0 (-110/-110)

The Panthers pulled off the biggest upset of the week last Sunday by beating the Packers as a 13.5-point underdog. Carolina’s defense forced multiple turnovers and had fourth down stops in critical situations. 

The Panthers are better than the Saints, and they have collected more wins on the season. New Orleans is rebuilding, and they haven’t been very successful throughout the season. 

The Panthers are getting better by the week, and Bryce Young has a clutch gene that can’t be replicated by anyone on the Saints. 

Jaguars vs. Texans Odds, Sunday, 1:00 PM EST

• Jaguars: Spread +1.0 (-105) | Moneyline +100

• Texans: Spread -1.0 (-115) | Moneyline -120

• Total: Over/Under 38.0 (-110/-110)

The Jaguars and Texans will clash in an AFC East battle on Sunday. Houston would have been favored in this game, but they’ll likely be without C.J. Stroud. 

Stroud hasn’t played great, but he is the Texans' best option at quarterback. Jacksonville is coming off an overtime win against the Raiders, so they have momentum on their side. 

They also have one of the best kickers in the league, Cam Little, who broke the NFL field goal record on Sunday. If the Jaguars replicate their Week 9 performance, they should be victorious against Houston. 

Cardinals vs. Seahawks Odds, Sunday, 4:05 PM EST

• Cardinals: Spread +6.5 (-110) | Moneyline +250

• Seahawks: Spread -6.5 (-110) | Moneyline -310

• Total: Over/Under 45.5 (-110/-110)

The Cardinals beat the Cowboys in Week 9, and it was a very impressive win. Yet, they forced three turnovers and only won by 10 points. 

Arizona will struggle to find these turnovers against a team like the Seahawks. Sam Darnold has been outstanding in 2025, and he has the best receiver in the league on his side in Jaxon Smith-Njigba. 

Seattle should roll the Cardinals at home in this game and continue their march to the playoffs. This will be a very difficult game for Kyler Murray to make his return, and it should show. 

Rams vs. 49ers Odds, Sunday, 4:05 PM EST

• Rams: Spread -3.5 (-105) | Moneyline -185

• 49ers: Spread +3.5 (-115) | Moneyline +155

• Total: Over/Under 49.5 (-110/-110)

As long as San Francisco has Christian McCaffrey, they have a chance to win. It seems like McCaffrey is coming close to 200 all-purpose yards weekly because of how many touches he gets on offense. 

The running back is the biggest piece in San Francisco’s success, and they have given him the ball consistently. The 49ers are outmatched by the Rams, but this NFC West matchup should be close. 

Puka Nacua is questionable for Sunday, and if he isn’t on the field, the 49ers could win outright. 

Lions vs. Commanders Odds, Sunday, 4:25 PM EST

• Lions: Spread -9.0 (-110) | Moneyline -450

• Commanders: Spread +9.0 (-110) | Moneyline +350

• Total: Over/Under 49.5 (-110/-110)

The Detroit Lions have been one of the best teams in the NFL over the years at responding following losses. The Lions tend to win and cover coming off a bad loss, and they have a great opportunity against Washington. 

The Commanders will be without Jayden Daniels, and they have one of the worst defenses in the NFL. Sam Darnold shredded Washington’s secondary last week, and this should be the case for Jared Goff. 

Washington doesn’t have the offense or defense to keep up with Detroit. 

Steelers vs. Chargers Odds, Sunday, 8:20 PM EST

• Steelers: Spread +3.0 (-120) | Moneyline +130

• Chargers: Spread -3.0 (+100) | Moneyline -155

• Total: Over/Under 45.0 (-110/-110)

The Pittsburgh Steelers have been one of the most consistent teams in the NFL under Mike Tomlin. They have a tough game this week because they have to travel to Los Angeles to face the Chargers. 

Yet, Pittsburgh is coming off one of their biggest wins of the season against the Colts. The Steelers' defense forced turnovers, which resulted in easy chances for the offense. 

Aaron Rodgers continues to shine at quarterback, and he can outplay Justin Herbert. The Chargers don’t take care of business consistently, and I expect them to struggle in this spot. 

Eagles vs. Packers Odds, Monday, 8:15 PM EST

• Eagles: Spread +2.5 (-110) | Moneyline +115

• Packers: Spread -2.5 (-110) | Moneyline -135

• Total: Over/Under 44.5 (-110/-110)

The Philadelphia Eagles are a 2.5-point underdog, which is surprising considering they’re better than the Packers. Bookmakers are expecting Green Bay to bounce back after a bad loss to the Panthers. 

However, they can’t be trusted after losing as a 13.5-point favorite. The best teams in the NFL don’t lose as heavy favorites, so Green Bay is disqualified from this conversation. 

Rest advantage plays a huge role in the NFL, and the Eagles have the edge in this spot. Since they’re coming off a bye week, they should be primed for a big game against the Packers.

Claim $200 in Bonus Bets at bet365 With a $5 Wager