US Open Women's Singles Preview Predictions, Betting Odds & Picks

Written by: Andy Schooler
Updated October 14, 2022
6 min read
Us Open Women Singles Predictions
  • Madison Keys can deliver success for the host nation
  • In-form Ons Jabeur a lively outsider
  • Seed Donna Vekic looks vulnerable to first-round upset

US Open Women’s Singles Odds

The odds for this tournament are provided by BetRivers. Click on the odds below to go directly to the sportsbook and place a bet. Good luck!

Player Odds
Naomi Osaka +400
Serena Williams +550
Sofia Kenin +1100
Karolina Pliskova +1100
Petra Kvitova +1600
Garbine Muguruza +1800
Madison Keys +2000
Johanna Konta +2000


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US Open Women’s Singles Predictions and Picks

Our Picks

Madison Keys outright winner +2500 at BetMGM – bet here!

Ons Jabeur to win her quarter +1700 at BetRivers – bet here!

Kristyna Pliskova over Donna Vekic +155 at DraftKings – bet here!

Madison Keys has a strong US Open record and will be aided by the faster conditions this year – back her at +2500 with BetMGM.

Ons Jabeur has made big strides in 2020, beating some top players. The Tunisian looks good value at +1700 to win her quarter with BetRivers and DraftKings.

Big-serving Kristyna Pliskova has the tools to topple seed Donna Vekic and cause a first-round upset. She’s a +155 chance with BetRivers and DraftKings.

How to Watch the US Open Women’s Singles

US Open Event Information
What US Open
Where Flushing Meadows, New York
When Monday, August 31 to Sunday, September 13
How to Watch ESPN, Tennis Channel share coverage

Madison Has the Keys to Success

Many recent Grand Slam tournaments have been described as ‘wide open’ on the women’s side but the 2020 US Open is something else.

The field is missing six of the world’s top 10 and 15 of the top 50 and many of the big names who are in the bio-secure ‘bubble’ in New York fail to offer convincing cases to back them.

As ever, Serena Williams will attract plenty of attention but after six months without a competitive match she was scratching around for form in both Lexington and New York (Flushing Meadows having already staged a warm-up event over the past week).

None of her five matches were won in straight sets with defeats suffered to Shelby Rogers (ranked outside the top 100) and Maria Sakkari.

The pressure of equalling Margaret Court’s record of 24 Grand Slam singles titles will arguably be greater than ever in this weakened field and that expectation (much self-imposed) has weighed heavily on the 38-year-old’s shoulders of late – she’s lost her last four Grand Slam finals.

Top seed Karolina Pliskova and Australian Open champion Sofia Kenin both lost in the first round last week and so Naomi Osaka is probably deserving of the favorite tag – the 2018 winner is at the time of writing due to contest the final of the New York warm-up event.

Yet she’s not been the most reliable player over the years and she’s going to have great scrutiny on her after she sparked last week’s 24-hour suspension with her Black Lives Matter withdrawal protest.

Preference is to look for a bigger price and American Madison Keys provides that – she’s at +2500 with BetMGM.

In Serena’s quarter of the draw but in the opposite half to Osaka, the big-hitting Keys has often played her best tennis in New York.

She reached the final here in 2017 and the semis in 2018. In 2015, 2016, and 2019 she made the last 16.

That’s a pretty strong record and while the surface has changed from DecoTurf to Laykold this year, the extra speed can work in her favor.

Few players hit the ball harder than Keys, whose powerful groundstrokes can win her almost any match.

Admittedly her game can subsequently go ‘off’ but that lack of consistency is built into the price.

Keys won in fast conditions in Cincinnati last season and also made the final in Brisbane earlier this.

She looks worth a wager in an event that should provide plenty of shocks.

Box Clever With Jabeur

With the many question marks surrounding those towards the top of the Futures market, this tournament provides the outsiders with a real shot at glory.

A characteristic I want from any underdog on my ticket is a proven ability to beat elite players and Ons Jabeur certainly has that.

The Tunisian has enjoyed a strong season – either side of the tour’s virus-related suspension.

Prior to the lockdown, Jabeur made the quarter-finals of both the Australian Open and the Qatar Open with Jo Konta and Karolina Pliskova among her victims. There was also a narrow defeat to world number two Simona Halep in Dubai, the African losing 7-6 in the final set.

Since the tour resumed there have also been last-eight runs in both Lexington and New York with Keys among those beaten.

With Kenin and Aryna Sabalenka both looking very opposable in her section of the draw, backing Jabeur to win her quarter at +1700 is the recommendation.

Pliskova Can Prey On Vulnerable Vekic

Kristyna Pliskova, the twin sister of top seed Karolina, looks capable of causing an upset in the first round of the US Open.

She takes on 18th seed Donna Vekic, who has beaten just two top-50 players this year and over the past 12 months has posted a pretty miserable 8-14 win-loss record at tour level.

Czech Pliskova spent a large part of the tour’s shutdown practicing and playing exhibition events with a large number of high-quality players in her homeland and that experience should have helped her game which, like her sister’s, is spearheaded by a big serve.

That delivery will be aided by the slick courts on show at Flushing Meadows this year.

Pliskova, who made the semi-finals of the hardcourt event in Shenzhen at the start of the season, returned to action earlier this month on clay and immediately claimed the notable scalps of both Petra Martic and Maria Sakkari.

I don’t think she’ll be too concerned about the switch to the faster surface and is worthy of support at +155 with DraftKings and BetRivers.

Image for Andy Schooler

Andy Schooler

Tennis Betting Analyst

Betting Picks
Andy is a sports journalist of more than 20 years’ experience and is a former betting editor of the UK-based website, Sporting Life. He has specialized in tennis for many years, previewing hundreds of ATP Tour events and reporting from tournaments such as the ATP Finals and Davis Cup final. Andy has also covered numerous other sports, with a particular interest in soccer and cricket.
Nationality: British
Education: N/A
Favourite Sportsbook: FanDuel Sportsbook
Favourite Casino: Party Casino
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