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Best Colts vs. Titans Prop Bets: Top NFL Offenses Face One of the League’s Worst Defenses

Published: October 25, 2025, 12:00 PM ET
5 min read
  • The Colts have allowed the second-most passing yards in the NFL this season

  • Jonathan Taylor is averaging 126 rushing and receiving yards per game

  • Tyler Warren has amassed over 60 receiving yards in three of his last four games

If you’re looking for prop bets in Week 8, don’t overlook the AFC South rivalry game between the Indianapolis Colts and the Tennessee Titans. The Colts are currently the highest-scoring team in the NFL, averaging 33.1 points per game. They have plenty of playmakers who can’t wait to face one of the league’s worst defenses. 

The most notable player in this game is Jonathan Taylor, who has become the frontrunner for the NFL Offensive Player of the Year award. Of course, don’t overlook Daniel Jones, who is among the contenders to win NFL Comeback Player of the Year. Finally, tight end Tyler Warren, while still something of a long shot because of his position, is among the top candidates for NFL Offensive Rookie of the Year.  

Best Colts vs. Titans Prop Bets

The bottom line is that there are a lot of excellent candidates for playing props in this game. We took a close look at all of the options and picked our three favorite props.

The odds for these props come from bet365 Sportsbook, which is ranked as one of the best prop betting sites. New users who sign up with our promo code WSN365 will get $200 in bonus bets after placing an initial $5 wager.

Colts vs Titans Prop BetsOddsGet $200 in Bonus Bets at bet365
Cam Ward Over 202.5 Passing Yards-110CLAIM HERE
Jonathan Taylor Over 119.5 Rushing and Receiving Yards-115CLAIM HERE
Tyler Warren Under 58.5 Receiving Yards-110CLAIM HERE

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Colts vs Titans 2025 10 26 Cam Ward

Cam Ward Over 202.5 Passing Yards (-110) at bet365 Sportsbook 

Surprisingly, this might be the easiest prop bet in this game. As inept as the Tennessee offense has been this season, Ward has started to throw for a lot of yards. He’s gone over 202.5 passing yards in four of his last five games, starting with a loss to the Colts earlier this season. In fact, Ward has gone over 250 yards in two of his last three games. With the Titans constantly playing from behind, Ward has become competent enough to rack up yards in the second half.

Equally important, the Indy pass defense is among the worst in the league. Only the Cowboys have allowed more passing yards than the Colts this season. In fairness, some of that is due to Indianapolis frequently playing with a lead. Of course, since the Colts are likely to lead most of this game, it opens the door for Ward to throw the ball a lot and put up impressive stats in a losing effort.

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Jonathan Taylor Over 119.5 Rushing and Receiving Yards (-115) at bet365 Sportsbook

There is no question that Taylor is a player you should bet on to succeed this week. Through seven games, he’s not only leading the NFL in rushing, but he’s also averaging 126 total rushing and receiving yards per game. Facing one of the worst defenses in the league is a golden opportunity for Taylor to have another big day, even if 120 all-purpose yards is a big hurdle.

Taylor has hit this mark in each of his past two games, doing so with rushing yards alone two weeks against the Cardinals. With the Titans giving up the third-most rushing yards in the league, there is every reason to believe they will struggle to contain Taylor. He’s also caught at least three passes in all but one game and has totaled at least 20 receiving yards in five of seven games, so his receiving numbers can help him get to 120 total yards. One way or another, Taylor should reach that mark against the Tennessee defense.

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Tyler Warren Under 58.5 Receiving Yards (-110) at bet365 Sportsbook 

Warren is on a roll, totaling over 60 receiving yards in three of his last four games. That’s why the over/under for his receiving total is so high this week. The total is arguably too high, especially for a game the Colts are likely to dominate, leading to more running plays than passing plays.

Meanwhile, the Tennessee defense has been surprisingly good at defending tight ends. Despite some issues at cornerback, the Titans have good safeties who can cover Warren better than most. No tight end has come close to reaching 60 receiving yards against Tennessee this season, including Warren, who had just 38 yards against them earlier this year. The Titans have faced quality tight ends like Trey McBride, Hunter Henry, and Dalton Schultz, who have all been limited to a modest total. That’s why we’re fading Warren this week despite his recent success.

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Bryan Zarpentine WSN Contributor

Bryan Zarpentine

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Bryan Zarpentine is a 2008 graduate of Syracuse University and has been working as a freelance writer and editor since 2010. During that time, he has contributed to countless sites while covering baseball, soccer, the NFL, college football, and college basketball.
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